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Secunderabad, India

Ramanathan R.,Government Arts College | Ramasamy R.,P.A. College | Krishnan S.,Sunshine Hospitals
International Journal of Pharma and Bio Sciences | Year: 2015

Glaucoma is one of the leading diseases which causes irreversible visual impairment and blindness throughout the world. It constitutes clinically and genetically heterogenous group of optic neuropathies. Specific mutations in the myocilin gene cause primary open angle glaucoma with varying age-of-onset and degree of severity. Though the structure of the gene and protein have been elucidated still the role of mutant protein is not clearly understood. To study myocilin and glaucoma-associated myocilin mutants in higher animals and to understand, how these molecules may alter intraocularpressure and outflow resistance, it would be more helpful if we have animal models which could be used in the study. For finding out suitable animal models, sequence anlysis approach has been the first step in many diseases. Here we took a sequence analysis approach to know more about the related orthologes of myocilin proteins from different species.

Gilbert A.,Research Solutions | Li C.S.,Research Solutions | Sancheti P.,Sancheti Institute for Orthopaedics and Rehabilitation | Hanson B.,AO Clinical Investigation | And 11 more authors.
Journal of Long-Term Effects of Medical Implants | Year: 2013

Methodology: Multi-center, cross-sectional, observational study. Study Center(s): Multiple centers in India. Number of Participants: 1,000. Primary Research Objective: To characterize patients and treatment utilized for orthopedic patients presenting to both private and public hospital centers in India with knee pain and symptoms suggestive of knee arthritis. Inclusion Criteria: All patients 18 years of age or older who present to a recruiting hospital for treatment of knee pain will be eligible for participation. The subjects must be able to understand and complete the questionnaire. Exclusion Criteria: Patients with total knee replacement, open wound or evidence of recent surgery, or with a current or a history of tumor and/or fracture in the tibial plateau, femoral condyle or patella, in the affected knee are not eligible. Study Outcomes: This study aims to characterize the following: general demographics of patients presenting with knee pain, severity of knee symptoms at time of presentation, severity of knee pathology at time of presentation, factors associated with the decision to seek medical care, previous treatments and health care contacts, planned treatment, and gaps in treatment perceived by the patient and treating surgeons. © 2013 by Begell House, Inc.

Mulpur P.,Sri Sathya Sai Institute of Higher Learning | Yadavilli S.,Sri Sathya Sai Institute of Higher Learning | Mulpur P.,Sunshine Hospitals | Kondiparthi N.,Sunshine Hospitals | And 4 more authors.
Physical Chemistry Chemical Physics | Year: 2015

The relatively low sensitivity of fluorescence detection schemes, which are mainly limited by the isotropic nature of fluorophore emission, can be overcome by utilizing surface plasmon coupled emission (SPCE). In this study, we demonstrate directional emission from fluorophores on flexible Ag-C60 SPCE sensor platforms for point-of-care sensing, in healthcare and forensic sensing scenarios, with at least 10 times higher sensitivity than traditional fluorescence sensing schemes. Adopting the highly sensitive Ag-C60 SPCE platform based on glass and novel low-cost flexible substrates, we report the unambiguous detection of acid-fast Mycobacterium tuberculosis (Mtb) bacteria at densities as low as 20 Mtb mm-2; from non-acid-fast bacteria (e.g., E. coli and S. aureus), and the specific on-site detection of acid-fast sperm cells in human semen samples. In combination with the directional emission and high-sensitivity of SPCE platforms, we also demonstrate the utility of smartphones that can replace expensive and cumbersome detectors to enable rapid hand-held detection of analytes in resource-limited settings; a much needed critical advance to biosensors, for developing countries. This journal is © the Owner Societies 2015.

Reddy V.G.,Sunshine Hospitals | Mootha A.K.,Sunshine Hospitals | Chiranjeevi T.,Sunshine Hospitals | Kantesaria P.,Sunshine Hospitals | And 2 more authors.
International Journal of Surgery Case Reports | Year: 2011

INTRODUCTION: Periprosthetic fracture following total knee arthroplasty is a potentially serious condition. Here we report a case of bilaterally symmetrical (mirror) fracture of supracondylar area following trivial trauma. PRESENTATION OF CASE: Both fractures were OTA 33A2 and according to Rorabeck classification they were type II. Both fractures were fixed by dual plating technique using non locking plates. Intra operative fracture site biopsy revealed marked osteopenia and hence the patient was treated for osteoporosis. DISCUSSION: Both fractures united well at 14 weeks. At final follow up of 6 years there were no radiological signs of implant loosening and the patient was able to walk without any aids and had a range of 80° and 60° flexion in the right and left knees respectively. CONCLUSION: We conclude that in the pre locking plate's era such difficult case has been successfully managed by dual plating technique. © 2011 Surgical Associates Ltd. Elsevier Ltd. All rights reserved.

Reddy V.G.,Sunshine Hospitals | Kumar R.V.,Sunshine Hospitals | Mootha A.K.,Sunshine Hospitals | Thayi C.,Sunshine Hospitals | And 2 more authors.
Indian Journal of Orthopaedics | Year: 2011

Background: Knee arthrodesis may be the only option of treatment in cases of chronic infected total knee arthroplasty (TKA) with concomitant irreparable extensor mechanism disruption, extensive bone loss or severe systemic morbidities. Circular external fixation offers possible progressive adjustment to stimulate the bony fusion and to make corrections in alignment. We evaluated the results of knee arthrodesis with one or two stage circular external fixator for infected TKA. Materials and Methods: 16 cases of femoro-tibial fusion were retrospectively evaluated. Male-to-female ratio was 10:6. Mean age of the patients was 62.2 years. Cierney-Mader classification was used for anatomical and physiological evaluation while the bone stock deficiency was classified into mild, moderate and severe. Surgical technique involved either single or two stage arthrodesis using circular external fixator. Results: Union was achieved in 15 patients (93.75%). The mean duration for union (frame application time) in these patients was 28.33 weeks (range 22 to 36 weeks). Analysis showed that in the group with frame application time of less than 28 weeks, the incidence of mild to moderate bone deficiency was 83.33%, while in the frame application time more than 28 weeks group the incidence was 20% (P-value 0.034). Similarly the incidence of Cierney-Mader 4B (Bl, Bs, Bls) was found to be 33.33% in the group of frame application time of less than 28 weeks, while it was 90% in the group with frame application time more than 28 weeks (P-value 0.035). Conclusion: Circular external fixator is a safe and reliable method to achieve knee arthrodesis in cases of deep infection following TKA. Severe bone stock deficiency and Cierney- Mader type B host are likely risk factors for prolonged frame application time. We recommend a two-stage procedure especially when there is compromised host or severe bone loss.

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