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Jaiswal S.,Dr Vijay Kumar Foundation | Jaiswal S.,SunRise University | Babar V.P.,Dr Vijay Kumar Foundation | Kumar V.,Dr Vijay Kumar Foundation | Kumar V.,Shiv Nadar University
Physical Review B - Condensed Matter and Materials Physics | Year: 2013

We report results of ab initio calculations on Y-doped anion Sin clusters with n = 4-20. Our results suggest two growth behaviors in the intermediate range of n = 8 and 20: (1) There is the formation of linked clusters in which a metal atom links two subclusters and (2) where silicon atoms form a cage structure and the metal atom is inside the cage to produce endohedral cages of silicon clusters. The cluster structures have been identified by comparing the calculated spectra of the electronic states with the photoemission spectra on anion clusters. Our results suggest that in some cases a higher energy isomer may be present in experiments. We report the calculations of the infrared and Raman spectra as well as the dipole moments, electron affinity, and polarizability that could provide other ways of identifying the growth behavior in these clusters. © 2013 American Physical Society.


Hadda T.B.,University Mohammed Premier | Ali M.A.,SunRise University | Ali M.A.,Universiti Sains Malaysia | Masand V.,Vidya Bharati College | And 3 more authors.
Medicinal Chemistry Research | Year: 2013

In this study, we have amalgamated computational methodologies, viz. Petra, Osiris and Molinspiration (POM) to identify pharmacophores and antipharmacophores for antibacterial/antiviral activities of some 2-pyrazolines derivatives. Lipophilicity and the presence of tautomerism process are the major factors that govern the orientation to antibacterial and/or antiviral activity. On other hand, it was observed that these compounds have two different active sites and can inhibit both antiviral and antibacterial strains. Further, we have carried out receptor-based electrostatic analysis to confirm the electronic, steric and hydrophobic requirements for future modifications. The analyses provide substantial idea about the structural features responsible for their combined antibacterial/antiviral activity and provide guidelines for further modifications, with the aim of improving the activity and selectivity of designed drugs targeting HIV and tuberculosis microorganisms. © 2012 Springer Science+Business Media, LLC.


Yoon Y.K.,Universiti Sains Malaysia | Ali M.A.,Universiti Sains Malaysia | Ali M.A.,New Drug Discovery Research | Ali M.A.,SunRise University | And 5 more authors.
Bioorganic and Medicinal Chemistry | Year: 2014

A total of 15 novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity. All compounds showed better inhibition on SIRT2 as compared to SIRT1. Among these, compound 5j displayed the best inhibitory activity for SIRT1 (IC50 = 58.43 μM) as well as for SIRT2 (IC50 = 45.12 μM). Cell cytotoxicity assays also showed that compound 5j possesses good antitumor activity against two different cancer cell lines derived from breast cancer (MCF-7 and MDA-MB-468). A simple structure-activity-relationship (SAR) study of the newly synthesized benzimidazole derivatives was also discussed. © 2013 Elsevier Ltd. All rights reserved.


PubMed | SREC, SunRise University and Institute of Engineering and Technology
Type: | Journal: SpringerPlus | Year: 2016

At present image processing methods hold a noteworthy position in unravelling various medical imaging challenges. The high risk disorders such as diabetic cardiomyopathy and diabetic retinopathy are considered as applications for proposed method. The dictum of this paper is on observing enhancement and segmentation of the cross sectional view of a blood capillary of a right coronary artery image of a diabetic patient and also retinal images. A hybrid model using hybrid morphological reconstruction technique as pre-processing with watershed segmentation method as post-processing is developed in this work.


Wei A.C.,Universiti Sains Malaysia | Ali M.A.,Universiti Sains Malaysia | Ali M.A.,New Drug Discovery Research | Ali M.A.,SunRise University | And 4 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

A series of fourteen dispiropyrrolidines were synthesized using [3+2]-cycloaddition reactions and were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in HTS (High Throughput Screen). Most of the compounds showed moderate to good activity with MIC of less than 20 μM. Compound 4′-(4-bromophenyl)-1′- methyldispiro[acenaphthylene-1,2′-pyrrolidine-3′,2″-indane]-2, 1″(1H)-dione (4c) was found to be the most active with MIC of 12.50 μM. © 2012 Elsevier Ltd. All rights reserved.


Ponnuchamy S.,Orchid Chemicals and Pharmaceuticals Ltd | Kanchithalaivan S.,Madurai Kamaraj University | Ranjith Kumar R.,Madurai Kamaraj University | Ashraf Ali M.,Universiti Sains Malaysia | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014

A series of novel hybrid heterocycles comprising arylidene thiazolidine-2,4-dione and 1-cyclopropyl-2-(2-fluorophenyl)ethanone were synthesized. These compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in High Throughput Screen. Most of the hybrid arylidene thiazolidine-2,4-diones displayed moderate to good activity with MIC of less than 50 μM. Compound 1m exhibited maximum potency being 5.87 fold more active at EC50 and 6.26 fold more active at EC90 than the standard drug pyrimethamine. © 2014 Elsevier Ltd. All rights reserved.


Sivakumar S.,Madurai Kamaraj University | Ranjith Kumar R.,Madurai Kamaraj University | Ashraf Ali M.,Universiti Sains Malaysia | Ashraf Ali M.,New Drug Discovery Research | And 2 more authors.
European Journal of Medicinal Chemistry | Year: 2013

The 1,3-dipolar cycloaddition of azomethine ylides generated in situ from acenaphthenequinone and α-amino acids viz. 1,3-thiazolone-4-carboxylic acid and piperidine-2-carboxylic acid to a series of 1-methyl-3,5-bis[(E)- arylmethylidene]tetrahydro-4(1H)-pyridinones afforded novel spiro[5.2″] acenaphthene-1″-onespiro[6.3′]-5′-arylmethylidene-1′- methylpiperidin-4′-one-7-aryltetrahydro-1H-pyrrolo[1,2-c] [1,3]thiazoles and spiro[2.2″]acenaphthene-1″-onespiro[3.3′]-5′- arylmethylidene-1′-methylpiperidin-4′-one-4- aryloctahydroindolizines respectively in quantitative yields. These compounds were evaluated for their AChE inhibitory activity and compound 3c was found to be the most potent with IC50 1.86 μmol/L. © 2013 Elsevier Masson SAS. All rights reserved.


Jeyachandran V.,Madurai Kamaraj University | Kumar R.R.,Madurai Kamaraj University | Ali M.A.,Universiti Sains Malaysia | Ali M.A.,New Drug Discovery Research | And 2 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

A library of novel 5-amino-2,7-diaryl-2,3-dihydrobenzo[b]thiophene-4,6- dicarbonitriles have been synthesized regioselectively in good yields through the one-pot domino reactions of 5-aryldihydro-3(2H)-thiophenones, malononitrile and aromatic aldehydes in the presence of morpholine. This transformation presumably involves Knoevenagel condensation-Michael addition-intramolecular Thorpe-Ziegler cyclization-Tautomerization-Elimination sequence of reactions. These compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity and 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6- dicarbonitrile was found to be the most potent against AChE with IC50 4.16 μmol/L. © 2013 Elsevier Ltd. All rights reserved.


Ashraf Ali M.,Universiti Sains Malaysia | Ismail R.,Universiti Sains Malaysia | Choon T.S.,Universiti Sains Malaysia | Kumar R.S.,Universiti Sains Malaysia | And 5 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

Pyrrolothiazolyloxindole analogues share vital pharmacological properties, considered useful in Alzheimer's disease (AD). The aim of this study was synthesis and evaluate pyralothiazolyloxindole analogues if possess acetyl cholinesterase (AChE) inhibitory activity. The easily accessible one-pot synthesis of these compounds resulted to be significantly less difficult and expensive than that of donepezil. Several compounds possess anti-cholinesterase activity in the order of micro and sub-micromolar. Particularly, compound 6a was the most potent inhibitors of the series against acetyl cholinesterase enzyme with IC 50 0.11 μmol/L. © 2011 Elsevier Ltd. All rights reserved.


PubMed | Vardhman Mahavir Medical College & Safdarjung Hospital and SunRise University
Type: Journal Article | Journal: Antimicrobial agents and chemotherapy | Year: 2016

Antimicrobial susceptibility testing of 258 Neisseria gonorrhoeae isolates by Etest determined that 60.1% were multidrug resistant (MDR), while 5% of the strains had decreased susceptibility to currently recommended extended-spectrum cephalosporins (ESCs). Among these, 84.5% of MDR strains and 76.9% of strains that had decreased susceptibility to ESCs were susceptible to gentamicin. No MDR isolate was resistant to gentamicin. These in vitro results suggest that gentamicin might be an effective treatment option for the MDR strains and in dual therapy for gonorrhea. However, further research regarding the clinical treatment outcomes is essential.

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