Sunder Deep Pharmacy College

Ghāziābād, India

Sunder Deep Pharmacy College

Ghāziābād, India
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Tiwari R.K.,Sunder Deep Pharmacy College | Udayabanu M.,Jaypee University of Information Technology | Chanda S.,Pharmacy Institute
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: The intent of this report was to investigate the effect of aqueous root extract of Clerodendrum serratum L. for antioxidant activity using divergent models, namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay, superoxide scavenging assay, and ferric reducing antioxidant power (FRAP) assay. Methods: The root of C. serratum was extracted using water. The yield of aqueous extract was 10% w/w. The outcome was examined statistically by the regression method. Results: The inhibitory concentration 50% values are 85.43 and 107.59 µg/ml for DPPH radical scavenging assay and superoxide scavenging assay, respectively, whereas FRAP showed a significant reducing power activity with increased concentration of sample. The pilot study showed a significant correlation existed between concentrations of the extract and percentage engrossment of free radicals. Conclusion: The antioxidant property may be corresponding to the polyphenols and flavonoids adjacent in the extract. These results clearly revealed that C. serratum might be effective against diseases analogous with free radical mediated. © 2017 The Authors.

Sharma S.,Sunder Deep Pharmacy College | Pathak S.,Suresh Gyan Vihar University | Gupta G.,Jaipur National University | Gupta G.,University of Newcastle | And 7 more authors.
Biomedicine and Pharmacotherapy | Year: 2017

In India syzygium cumini (Myrtaceae) is commonly used traditional medicine to treat diabetes. The present study was undertaken to assess an investigation of antihyperglycemic and antidyslipidemic properties of aqueous extract of Syzigium Cumini (SC) in diabetic rats fed a high cholesterol diet. The aqueous extract of SC was screened for antihyperglycemic and antidyslipidemic activity by streptozotocin induced diabetes in rats. Animals were treated with 100, 200 and 400 mg/kg body weight of aqueous extract of SC. Metformin were used as reference antihyperglycemic drugs for comparison. Administration of aqueous extract of SC or metformin for 21 days resulted in a significant (P < 0.05) reduction in serum glucose, insulin and Homeostasis model assessment of insulin resistance (HOMA-IR) compared with diabetic controls. Treatment with 100 mg/kg/day aqueous extract of SC did not result in a significant reduction in serum insulin levels, but 200 mg/kg/day and 400 mg/kg/day, aqueous extract of SC and metformin showed significant reductions 17.89%, 19.60% and 24.40%, respectively. Furthermore, administration of 100, 200 and 400 mg/kg/day, aqueous extract of SC and metformin resulted in significant decrease in insulin resistance of 19.20%, 41.59%, 51.55% and 68.68%, respectively. In high fat diet- streptozotocin (HFD – STZ) treated rats β-cells function (HOMA-B) were markedly reduced (5.8-fold), however observed a significant (P < 0.01) improvement of β-cell function with aqueous extract of SC (400 mg/kg/day) and metformin. The aqueous extract of SC seeds exhibits significant insulin-sensitizing, antidyslipidemic, antioxidant, anti-inflammatory and β-cell salvaging activity in HFD-STZ-induced type 2 diabetic rats via overexpression of PPARγ and PPARα activity, affirming its potential to be used in the prevention and treatment of type 2 diabetes mellitus (T2DM). Further isolation and characterization of active components in SC seed extract are needed to explore the other possible mechanisms and pathways that are involved in its anti-diabetic effect. © 2017 Elsevier Masson SAS

Tiwari R.K.,Sunder Deep Pharmacy College | Udayabanu M.,Jaypee University of Information Technology | Chanda S.,NIET Pharmacy Institute
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: Clerodendrum serratum (L.) belonging to family Verbenaceae, commonly known as Bharangi, is a popular plant across various communities of India. Gas chromatography-mass spectrometry (GC-MS) is a unique technique to prospect various volatile principles and semivolatile compounds. Materials and Methods: The phytoconstituents present in the root of n-hexane extract were evaluated by GC-MS using Clarus 500 mass spectrometer. Results and Discussions: A total of 15 constituents were identified and characterized from the roots of C. serratum L. All the 15 compounds were tabulated with their retention time, percentage peak area, molecular formula, molecular weight, and Chemical Abstracts Service number. Out of all the compounds, 60% comprises the oxygenated compounds. Compound hexadecanoic acid, methyl ester, and benzene, 1,3-bis(1,1-dimethylethyl) showed highest percentage about 6.5 and 74.9, respectively. Conclusion: This study showed the presence of 15 compounds ranging from alkane, alkene as longest chain along with ester, aromatic and non-aromatic hydrocarbons. © 2017 The Authors. Published by Innovare Academic Sciences Pvt Ltd.

Sharma S.K.,Sunder Deep Pharmacy College | Sharma S.M.,University of Rajasthan | Vipin S.,MM University | Sharmistha M.,Sunder Deep Pharmacy College
International Journal of Drug Development and Research | Year: 2013

Most of the synthetic drugs used at present as analgesic and antiinflammatory agents cause many side effects and toxic effects. Many medicines of plant origin with analgesic and antiinflammatory activity have been used since long time without adverse effects. The plant Abutilon indicum (AI) is reported to be used as a febrifuge, anthelmintic and anti-inflammatory agent. It is also used to treat ulcers, toothache and hepatic disorders. Thus the present study was undertaken to investigate the analgesic and antiinflammatory potential of the plant Abutilon indicum. The formalin induced paw licking and tail flick method were used to study the analgesic activity of ethanolic and aqueous extracts of the plant. Carrageenan induced hind paw edema model was used to study anti-inflammatory activity. 200 mg/kg dose was selected to study both activities. Wistar strain albino rats were used for all studies. Diclofenac sodium (5 mg/kg) was used as the standard drug. In tail flick test the increase in the reaction time was highly significant (P < 0.001) with ethanolic and aqueous extracts of the plant Abutilon indicum as compared to the control group. Acute edema in the left hind paw of the animals was induced by sub plantar injection of 0.1 ml (1%) carrageenan suspension in normal saline. The ethanolic extract of the plant significantly (P <0.01) reduced the paw edema in carrageenan treated rats. The effect was maximum at 3hr after the carrageenan injection. The significant suppression of inflammation during the whole experimental period indicates the long duration of action of the ethanolic extract of the plant. Preliminary phytochemical investigation revealed the presence of glycosides, flavonoids, saponins and phenolic compounds in the ethanolic extract of the plant under study. The phytochemical constituents present in these extracts may be responsible for the analgesic and anti-inflammatory activities of the plant Abutilon indicum and the actions may be mediated through CNS and peripheral mechanisms. © 2013 IJDDR, Prof. S K Sharma et al.

Shalini S.,Sunder Deep Pharmacy College | Kumar R.R.,Dv Institute Of Pharmacy And Medicine | Birendra S.,Jaipur National University
International Journal of PharmTech Research | Year: 2015

Phytosomes are lipid soluble advanced herbal complexes known to increase the bioavailability of water soluble constituents. Terminali aarjuna is a plant rich in polyphenols. Methanolic extract of bark of Terminalia arjuna is well known for its lipid lowering effects. Phytosomes of methanolic extract ofTerminalia arjuna were prepared.The antihyperlipidemic effect of orally administered methanolic extract of Terminalia arjuna bark and its phytosomeswas investigated on cholesterol fed albino wistar rats. At the end of the experimental period, the animals were killed and their plasma and tissue lipid components were estimated. Histological studies show that both methanolic extract of Terminalia arjuna bark and phytosomes of methanolic extract of Terminalia arjuna bark show negligible fatty infiltration and granular degeneration. The studies shows that complex was effective in decreasing the total cholesterol as well as triglycerides and raising high density cholesterol but the activity was low as compared to pure extract probably because of the presence of phospholipids.Thus phytosomal complexes of methanolic extract of Terminaliaarjuna should be prescribed to the patients accordingly. © 2015, Sphinx Knowledge House. All rights reserved.

Chauhan D.,Sunder Deep Pharmacy College | Siddiqui A.A.,Sunder Deep Pharmacy College | Kataria R.,Sunder Deep Pharmacy College | Singh R.,Sunder Deep Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objective: Synthesis, characterization and antimicrobial evaluation of some new 1,3-benzothiazolyl pyrazole derivatives. Methods: Aseries of novel2-[3-(substituted phenyl)-4-formylpyrazol-1-yl]-6-chloro benzothiazole derivatives (5a-g) have been synthesized by cyclization through Vilsmeier-Haack reaction on hydrazones (4a-g)of substituted aromatic ketones with 6-chloro benzothiazol-2-yl hydrazine under microwave irradiation in fairly good yields. All the newly synthesized compounds were characterized by IR, 1HNMR, Mass spectral studies and elemental analysis and were screened for their in vitro antibacterial and antifungal activities also. Results: The results revealed that all 1,3-benzothiazole pyrazole derivatives(5a-g) were synthesized in satisfactory yields and pharmacologically evaluated for their in vitro antimicrobial activity. All the synthesized compounds were in good agreement with elemental and spectral data. Some of the tested compounds showed good to moderate antimicrobial activity against all tested pathogenic bacterial and fungal strains. Conclusion: For the present investigation we have prepared benzothiazole derivatives that are incorporated with pyrazolyl moiety with the hope of potentiating the activity of two such units in the same compound. Compounds 5b, 5c, and 5a showed excellent antibacterial and antifungal activities as compared to reference drugs norfloxacin and ketoconazole. © 2015, International Journal of Pharmacy and Pharmaceutical Science. All rights reserved.

Chauhan D.,Sunder Deep Pharmacy College | Siddqui A.A.,Hamdard University | Kataria R.,ITS Paramedical College Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

A new series of 1-(6-amino-1,3-benzothiazol-2-yl)-3-(substitutedphenyl)-1H-pyrazole-4-carbaldehyde, 5a-g, were synthesized. All the newly synthesized compounds were screened for their in vitro antibacterial activity, against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and for antifungal activity against Aspergillus niger and Candida albicans. Compounds 5b, 5f, 5d, 5a showed excellent in vitro antibacterial activity and antifungal activity than the standard drugs. All the compounds were characterized by IR, 1HNMR, LCMS mass and C, H, N analyses.

Rastogi S.,Sunder Deep Pharmacy College | Rastogi H.,Sunder Deep Pharmacy College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2010

Microwave assisted organic reaction enhancement (MORE) is a simple, clean, fast, efficient, economic and environment friendly method for the synthesis of 2, 6-diaryl-3-methyl-4-piperidones by condensation of ethyl methyl ketone, benzaldehyde, substituted aromatic aldehydes and ammonium acetate. Thiosemicarbazone derivatives of 2, 6-diary.-3-methyl-4-piperidones have been synthesized by reaction with thiosemicarbazide. Using microwave irradiation, all the reaction could be completed in very short duration (4-7 min) with considerable increase in the yields (53.2-80.8%). All the synthesized compounds have been evaluated for their anticonvulsant activity by maximal electroshock method. Compounds 1b, 3b and 6b have been found to exhibit excellent anticonvulsant activity.

Singh S.,Sunder Deep Pharmacy College | Khan Md.K.,Biotech Park | Sharma S.K.,Sunder Deep Pharmacy College | Singh L.,Sunder Deep Pharmacy College
Journal of Chemical and Pharmaceutical Sciences | Year: 2014

An alarming increase in bacterial strains resistant to existing antimicrobial agents demands a renewed effort to seek agents effective against pathogenic bacteria resistant to current antimicrobials. Hamelia patens extracts was studied for antibacterial and antifungal activity against various clinical isolates of the bacteria and fungi, in varying concentration by Agar well diffusion method and serial dilutions. The extracts showed pronounced concentration dependent antibacterial activity against Gram positive and Gram negative bacteria and also antifungal activity. Various extracts of Hamelia patens inhibited the growth of Staphylococcus aureus, Bacillus subtilis, Pseudomonas flurescens, Escherichia coliand Aspergillus niger, Penicillium chrysogenum, Alternaria alternata. Six extracts of Hamelia patenswere analyzed for their antioxidant activity by Hydrogen peroxide scavenging activity. The six extract along with the reference sample, Gallic acid were further analysed to determine toal phenolic content by Folin - Ciocalteau method. The data obtained in the in vitro models clearly establish the antioxidant potency of all extracts. © 2014, SPB Pharma Society. All rights reserved.

Snigdha M.,Sunder Deep Pharmacy College | Kumar S.S.,Sunder Deep Pharmacy College | Sharmistha M.,Sunder Deep Pharmacy College | Deepa C.,Sunder Deep Pharmacy College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Vetiveria zizanioides (Linn.) Nash, a member of the family Poaceae commonly known as the Khas-Khas, Khas or Khus grass in India, is a perennial grass with thick fibrous adventitious roots which are aromatic and highly valued. This tufted grass grows throughout the plains of India ascending up to an elevation of 1200 m. Having wide ecological amplitude, this grass grows in a wide variety of ecological habitats covering all bio-geographic provinces of India. The used parts are roots, leaves, stem. Over 150 compounds have been isolated and characterized from vetiver oil so far. A major portion of oil consist of sesquiterpenoide, hydrocarbons and their oxygenated derivatives, phytochemical screening of the powdered leaves shows the presence of alkaloids, flavonoids, tannins, phenols, terpenoids and saponins. The roots are aromatic, antifungal action, cooling, antiemetic, diaphoretic, haemostatic, expectorant, diuretic, stimulant, hysteria, insomnia, skin diseases, asthma, amentia, amenorrhoea, antispasmodic, kidney problems, gall stones, mosquito repellent and antioxidants.

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