Sunder Deep Pharmacy College

Ghāziābād, India

Sunder Deep Pharmacy College

Ghāziābād, India

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Chauhan D.,Sunder Deep Pharmacy College | Siddqui A.A.,Hamdard University | Kataria R.,ITS Paramedical College Pharmacy
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

A new series of 1-(6-amino-1,3-benzothiazol-2-yl)-3-(substitutedphenyl)-1H-pyrazole-4-carbaldehyde, 5a-g, were synthesized. All the newly synthesized compounds were screened for their in vitro antibacterial activity, against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and for antifungal activity against Aspergillus niger and Candida albicans. Compounds 5b, 5f, 5d, 5a showed excellent in vitro antibacterial activity and antifungal activity than the standard drugs. All the compounds were characterized by IR, 1HNMR, LCMS mass and C, H, N analyses.

Rastogi S.,Sunder Deep Pharmacy College | Rastogi H.,Sunder Deep Pharmacy College
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2010

Microwave assisted organic reaction enhancement (MORE) is a simple, clean, fast, efficient, economic and environment friendly method for the synthesis of 2, 6-diaryl-3-methyl-4-piperidones by condensation of ethyl methyl ketone, benzaldehyde, substituted aromatic aldehydes and ammonium acetate. Thiosemicarbazone derivatives of 2, 6-diary.-3-methyl-4-piperidones have been synthesized by reaction with thiosemicarbazide. Using microwave irradiation, all the reaction could be completed in very short duration (4-7 min) with considerable increase in the yields (53.2-80.8%). All the synthesized compounds have been evaluated for their anticonvulsant activity by maximal electroshock method. Compounds 1b, 3b and 6b have been found to exhibit excellent anticonvulsant activity.

Singh S.,Sunder Deep Pharmacy College | Khan Md.K.,Biotech Park | Sharma S.K.,Sunder Deep Pharmacy College | Singh L.,Sunder Deep Pharmacy College
Journal of Chemical and Pharmaceutical Sciences | Year: 2014

An alarming increase in bacterial strains resistant to existing antimicrobial agents demands a renewed effort to seek agents effective against pathogenic bacteria resistant to current antimicrobials. Hamelia patens extracts was studied for antibacterial and antifungal activity against various clinical isolates of the bacteria and fungi, in varying concentration by Agar well diffusion method and serial dilutions. The extracts showed pronounced concentration dependent antibacterial activity against Gram positive and Gram negative bacteria and also antifungal activity. Various extracts of Hamelia patens inhibited the growth of Staphylococcus aureus, Bacillus subtilis, Pseudomonas flurescens, Escherichia coliand Aspergillus niger, Penicillium chrysogenum, Alternaria alternata. Six extracts of Hamelia patenswere analyzed for their antioxidant activity by Hydrogen peroxide scavenging activity. The six extract along with the reference sample, Gallic acid were further analysed to determine toal phenolic content by Folin - Ciocalteau method. The data obtained in the in vitro models clearly establish the antioxidant potency of all extracts. © 2014, SPB Pharma Society. All rights reserved.

Snigdha M.,Sunder Deep Pharmacy College | Kumar S.S.,Sunder Deep Pharmacy College | Sharmistha M.,Sunder Deep Pharmacy College | Deepa C.,Sunder Deep Pharmacy College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Vetiveria zizanioides (Linn.) Nash, a member of the family Poaceae commonly known as the Khas-Khas, Khas or Khus grass in India, is a perennial grass with thick fibrous adventitious roots which are aromatic and highly valued. This tufted grass grows throughout the plains of India ascending up to an elevation of 1200 m. Having wide ecological amplitude, this grass grows in a wide variety of ecological habitats covering all bio-geographic provinces of India. The used parts are roots, leaves, stem. Over 150 compounds have been isolated and characterized from vetiver oil so far. A major portion of oil consist of sesquiterpenoide, hydrocarbons and their oxygenated derivatives, phytochemical screening of the powdered leaves shows the presence of alkaloids, flavonoids, tannins, phenols, terpenoids and saponins. The roots are aromatic, antifungal action, cooling, antiemetic, diaphoretic, haemostatic, expectorant, diuretic, stimulant, hysteria, insomnia, skin diseases, asthma, amentia, amenorrhoea, antispasmodic, kidney problems, gall stones, mosquito repellent and antioxidants.

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