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Jia J.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Fei H.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Zhou M.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Zhou M.,SunaTech Inc.
Electrophoresis | Year: 2012

This article reports a new class of luminescent metal complexes, biscyclometalated iridium(III) complexes with an ancillary bathophenanthroline disulfonate ligand, for staining protein bands that are separated by electrophoresis. The performances of these novel staining agents have been studied in comparison with tris(bathophenanthroline disulfonate) ruthenium(II) tetrasodium salt (i.e. RuBPS) using a commercially available imaging system. The staining agents showed different limits of detection, linear dynamic ranges, and protein-to-protein variations. The overall performances of all three stains were found to be better than or equivalent to RuBPS under the experimental conditions. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Zhang Q.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Zhang Q.,University of Chinese Academy of Sciences | Zhang Q.,CAS Institute of Chemistry | Zhou M.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Zhou M.,SunaTech Inc.
Talanta | Year: 2014

A ratiometric pH probe composed of a fluorescein moiety and an ionic near-infrared-emitting phosphorescent cyclometalated iridium(III) complex bis(6-(benzo[b]thien-2-yl)phenanthridinato)(4-(3-carboxypropyl)-4′-methyl-2,2′-bipyridine)iridium(III) was synthesized. With good cell permeability, the probe demonstrated a linear ratiometric response to the pH variation in the physiological range in HeLa cell assay. © 2014 Elsevier B.V. All rights reserved. Source


Zhuang J.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Li W.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Su W.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Zhou M.,SunaTech Inc. | Cui Z.,CAS Suzhou Institute of Nano Technology and Nano Bionics
New Journal of Chemistry | Year: 2014

A novel bipolar host material 9-(3-(5-(4-(diphenylphosphoryl)phenyl)-4- phenyl-4H-1,2,4-triazol-3-yl)phenyl)-9H-carbazole (CTPO) with carbazole, triazole and phosphine oxide moieties was designed and synthesized. CTPO was found to exhibit a high glass transition temperature (Tg = 127 °C), suitable HOMO and LUMO levels (5.65 and 2.42 eV), a high triplet energy (3.06 eV) and excellent bipolar properties. A device with 15 wt% doping concentration showed a low turn-on voltage of 2.5 V and maximum current and power efficiencies of 41.6 cd A-1 and 43.0 lm W-1, respectively. A high efficiency of 40.1 cd A-1 was achieved at the brightness of 100 cd m-2. Even at a high luminance of 1000 cd m -2, the efficiency remained as high as 35.2 cd A-1. © 2014 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. Source


Zhang Q.,CAS Suzhou Institute of Nano Technology and Nano Bionics | Zhang Q.,University of Chinese Academy of Sciences | Zhang Q.,CAS Institute of Chemistry | Cao R.,CAS Suzhou Institute of Nano Technology and Nano Bionics | And 4 more authors.
Dalton Transactions | Year: 2014

Two phosphorescent iridium(iii) complexes conjugated to a lipophilic triphenylphosphonium cation moiety, IrMitoOlivine and IrMitoNIR, were synthesized. The complexes show high mitochondria-specificity and relatively lower cytotoxicity. Time-lapse confocal imaging indicates that both complexes exhibit an excellent anti-photobleaching capability under continuous laser irradiation. © 2014 the Partner Organisations. Source


Yu L.,SunaTech Inc. | Liu Y.,SunaTech Inc. | Zhou M.,Rubipy Scientific Inc.
Analytical and Bioanalytical Chemistry | Year: 2016

Ruthenium(II) complexes with carboxylic acid as a bioconjugatable group, i.e., [Ru(bathophenanthroline disulfonate)(2,2′-bipyridine)(4-methyl-4′-(3-carboxypropyl)-2,2′-bipyridine)]0, (C49H38N6O8S2Ru), and [Ru(bathophenanthroline disulfonate)2(4-methyl-4′-(3-carboxypropyl)-2,2′-bipyridine)]2− · 2Na+, (C63H44N6O14S4RuNa2) were characterized spectroscopically and electrochemically. As potential labels for electrochemiluminescence (ECL) immunoassays, the ECL intensities of the free labels in homogenous aqueous buffer solutions were compared under a condition that is similar to the one employed by a commercial clinical immunoassay system. The two labels were found to be more emissive and, thus, can be detected at 10- 12 pM compared with 5× 10−12 pM of the label currently used in the commercial ECL system. Furthermore, the improved ECL emission of the free labels in homogenous solutions was proven to be translated into more intense ECL signal in heterogeneous sandwich immunoassay and, thus, leading to a lower limit of detection in immunoassay. The data obtained from these ECL labels shed light on the further development of ECL-based clinical immunoassay technology. [Figure not available: see fulltext.] © 2016 Springer-Verlag Berlin Heidelberg Source

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