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Seth A.K.,Sumandeep Vidyapeeth University
Research Journal of Medicinal Plant | Year: 2011

Inflammatory diseases including different types of rheumatic diseases are a major and world wide problem. Gastrointestinal side effect is the major problem associated with the presently available non-steroidal anti-inflammatory agents. Now a days world population moves towards herbal remedies for treatment of such ailments. The numbers of plants have been screened for their anti-inflammatory and anti-arthritic activity, but only few of them reached up to the clinical level. This problem is mainly due to purely academic oriented research. Researchers have to lay emphasis on the phytoconstituents obtained form that plant for the specific treatment of such disease and not only to increase the number of plants having anti-inflammatory activity but have to work towards tapping their therapeutic utility by finding out the mechanism of action at molecular level. In this review we have described some of the families with respect to its antiinlammatory mechanism of action. © 2011 Academic Journals Inc.


Patel H.J.,Sumandeep Vidyapeeth University | Patel J.S.,H N Shukla Institute Of Pharmaceutical Education And Research | Patel K.D.,Visveswarpura Institute of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2010

Amlodipine besilate, an antihypertensive drug has a half-life of 35-50 hours and a bioavailability of 60-65 %. It undergoes extensive first pass metabolism. The Present study aims to evaluate suitability of transdermal drug delivery of amlodipine besilate. The partition coefficient in octanol / water system was studied, the effect of permeation enhancers SLS, β-cyclodextrin, DMSO, tween 20, sodium tauroglycolate and hyaluronidase on the drug release were studied using parchment paper. The flux and enhancement ratio calculations of amlodipine besilate were studied. The results indicated that the hyaluronidase enzyme show higher permeability and steady state flux increased linearly with increasing donor concentration.


PubMed | Government Dental College and Hospital and Sumandeep Vidyapeeth University
Type: Journal Article | Journal: Indian journal of dentistry | Year: 2016

Cystic hygroma is a benign congenital malformation of the lymphatic system that occurs in infant or children younger than 2 years of age. Although cystic hygroma is well recognized in pediatric practice, it seldom presents de novo in adulthood. These are commonly present in head and neck but can be present anywhere. Cystic hygroma is very rare in adults, but it should be considered in the differential diagnosis of adult neck swellings. Patients presenting with a painless, soft, fluctuant, and enlarging neck mass should have a careful history and physical examination along with radiological imaging to assist with diagnosis. Surgical intervention is the treatment of choice for this rare condition. Here, we are reporting a case of cystic hygroma in a 32-year-old male patient in the neck region. The objectives of this case report are to discuss the clinical presentation, diagnosis, histopathological findings and management of this malformation.


Sheth S.K.,Sumandeep Vidyapeeth University | Patel S.J.,Sumandeep Vidyapeeth University | Shukla J.B.,Veer Narmad South Gujarat University
International Journal of Pharma and Bio Sciences | Year: 2010

Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties. The purpose of this study was to develop a taste masked oral disintegrating tablet of poorly soluble Lornoxicam by direct compression technique with β-cyclodextrin (BCD) complexes using various super disintegrants like sodium starch glycolate, crospovidone and croscarmellose sodium. Prepared tablets were evaluated for different properties like drug content, hardness, friability, disintegration time and in vitro dissolution study. The different formulations showed disintegration time between 22 to 58 s. Drug release showed time between the ranges of 8 to 20 min. Among all the formulations, L6 showed 99.85% drug release within 8 min. Thus, L6 was considered best among the other formulations. The stability study was conducted as per the ICH guidelines and the formulations were found to be stable, with insignificant change in hardness, drug content and disintegration time. The tablets showed enhanced dissolution hence better patient compliance.


PubMed | Sumandeep Vidyapeeth University and Manubhai Patel Dental College and Hospital
Type: Journal Article | Journal: Journal of oral and maxillofacial pathology : JOMFP | Year: 2014

Oral mucocele is the most common benign minor (accessory) salivary gland lesion, caused due to mechanical trauma to the excretory duct of the gland. Clinically they are characterized by single or multiple, soft, fluctuant nodule, ranging from the normal color of the oral mucosa to deep blue. It affects at any age and is equally present in both sexes with highest incidence in second decade of life. They are classified as extravasation or retention type.To analyze the data between 2010 and 2011 of, clinically and histopathologically diagnosed 58 oral mucoceles for age, gender, type, site, color, cause, symptoms and dimension.Oral mucoceles were highly prevalent in the age group of 15-24 years, were seen in 51.72% of males and 48.28% of females, with a ratio of 1.07:1. The extravasation type (84.48%) was more common than the retention type (15.52%). The most common affected site was lower lip (36.20%) followed by ventral surface of the tongue (25.86%). The lowest frequency was observed in floor of mouth, upper lip and palate. The maximum numbers of mucoceles were asymptomatic (58.62%), and the color of the overlying mucosa had color of adjacent normal mucosa (48.28%). It was also observed that most of the mucoceles had diameter ranging from 5 to 14 mm. The causative factors of the lesion were lip biting (22.41%), trauma (5.18%) and numerous lesions (72.41%).Oral Mucoceles are frequently seen in an oral medicine service, mainly affecting young people and lower lip, measuring around 5 to 14 mm and the extravasation type being the most common.


Liu M.C.,Mount Sinai School of Medicine | Tirth S.,Mount Sinai School of Medicine | Appasani R.,MINDS Foundation | Shah S.,Sumandeep Vidyapeeth University | Katz C.L.,Mount Sinai School of Medicine
Journal of Nervous and Mental Disease | Year: 2014

Limited data exist regarding community attitudes and knowledge about clinical depression in rural India. We administered 159 questionnaires and 7 focus groups to Gujarati villagers to explore knowledge and beliefs about clinical depression. Quantitative datawere analyzed for frequencies, nonparametric correlations, and principal components, whereas qualitative data were coded for prominent themes. Two groups of subjects emerged from our analysis: one "medically oriented" group that viewed depression as a medical condition and expressed optimism regarding its prognosis and one "spiritually oriented" group that expressed pessimism. Correlations emerged between etiological belief, degree of optimism, and associated stigma. The subjects were pessimistic when they attributed depression to a traumatic event, punishment from God, or brain disease but optimistic when depression was attributed to socioeconomic circumstances. Overall, the subjects were knowledgeable and open-minded toward depression and demonstrated curiosity and willingness to learn more. This study will help to inform future clinical and educational outreach in rural Gujarat. © 2014 by Lippincott Williams & Wilkins.


Mittal V.V.,Rajiv Gandhi University | Patel S.J.,Sumandeep Vidyapeeth University | Sheth S.K.,Sumandeep Vidyapeeth University
International Journal of Pharma and Bio Sciences | Year: 2010

The main objective of this study was to develop and characterize tumor selective folate conjugated PEG (Polyethylene glycol) polymeric nanoparticulate system for paclitaxel delivery. Paclitaxel -loaded poly (lacticco-glycolic acid) (PLGA) nanoparticles were prepared by the solvent evaporation method and characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM) and zeta potential measurements. Result showed that preparation allowed the formation of spherical nanometric (200-300 nm), homogeneous and negatively charged particles (-23.9 mV) suitable for intravenous administration. Paclitaxel loading efficiencies were determined and release studies were performed in Tween 80 (0.1% w/v)-containing PBS at 37 °C. Prepared nanoparticles were surface modified by folate-PEG for targeting cancer cells, which is confirmed by FT-IR spectroscopy and characterized for shape, size and zeta potential measurements. The results demonstrate that folate conjugated PEG nanoparticle drug delivery system could provide increased therapeutic benefit by delivering the encapsulated drug to the folate receptor positive cancer cells.


Sahoo U.,Sumandeep Vidyapeeth University | Seth A.K.,Sumandeep Vidyapeeth University | Balaraman R.,Sumandeep Vidyapeeth University | Velmurugan R.,Century Pharmaceuticals Ltd.
Asian Journal of Chemistry | Year: 2015

A series of 2-[2-(4-cyanophenyl)-6-substituted-1H-benzimidazol-1-yl]-N-[2-(substituted)-4-oxo-1,3-thiazolidin-3-yl]acetamide [9(I-XXXI)] were synthesized. Substituted o-phenylenediamine was reacted with substituted 4-cyanobenzaldehydes in the presence of sodium metabisulfite to furnish substituted 2-(4-cyanophenyl)-1 H -benzimidazoles (1). When these substituted 2-(4-cyanophenyl)-1H-benzimidazoles were further treated with ethyl chloroacetate in KOH/DMSO, N-alkylated product (2-(4-cyanophenyl)-benzimidazol-1-yl)-acetic acid ethyl esters (2) was formed. To synthesize 2-(4-cyanophenyl)-benzimidazol-1-yl-acetic acid hydrazides (3) chemical reactions were conducted between hydrazine hydrate and the esters (2). When a mixture of 2-(4-cyanophenyl)-benzimidazol-1-yl)-acetic acid hydrazide (3) react with substituted aldehydes in ethanol was reflux, imines intermediates [4(I-XXXI) ] was formed. To synthesize 9(I-XXXI) reactions were occurred between a mixture of imine intermediate and thioglycollic acid in dioxane. The structures of newly synthesized compounds 9(I-XXXI) was confirmed by spectroscopic techniques. All the synthesized compounds were screened for its in vitro antioxidant and antiinflammatory activity. The in vitro antioxidant and antiinflammatory activity might be attributed due to the presence of more electrons withdrawing group and moiety having more lipophilicity also more electronegativity in nature. © 2015, Chemical Publishing Co. All rights reserved.


Parikh B.,Sumandeep Vidyapeeth University
Indian journal of dental research : official publication of Indian Society for Dental Research | Year: 2011

Periradicular surgery aims to achieve complete wound healing and regeneration of the periodontal unit. Platelet-rich plasma (PRP) is a platelet concentrate that is widely used to promote tissue healing, and bone induction through its various growth factors has been used in this study. This case report describes the use of PRP unilaterally in a bilateral periapical lesion in the same patient. The site treated with PRP showed better healing than the untreated site. This was confirmed with computed tomography (CT) scan readings. It was hypothesized that PRP could promote tissue regeneration and alveolar bone repair.


Vinzuda D.U.,Knv Pharmacy College | Sailor G.U.,Sumandeep Vidyapeeth University | Sheth N.R.,Saurashtra University
International Journal of ChemTech Research | Year: 2010

A simple, rapid, sensitive, reverse phase isocratic RP-HPLC method was developed for determination of Valsartan in tablet dosage form. The method was carried out using Thermo-hypersil ODS column (150 mm × 4.6 mm i.d., 5 μm particle size) with mobile phase comprised of water: acetonitrile: glacial acetic acid (500:500:01). The flow rate was set at 1.0 ml/min and effluent was detected at 273nm. The retention time of valsartan was found to be 4.6 minute. The method was validated for specificity, accuracy, precision, linearity, limit of detection, limit of quantification, robustness and solubility stability. LOD and LOQ were found to be 2.72 μg/ml and 8.25 μg/ml respectively. The calibration curve was linear in the concentration range of 40-140 μg/ml with coefficient of correlation 0.9990. The percentage recovery for the valsartan was found to be 99.0-100.2 and the % RSD was found to be less than 2 %. The proposed method was successfully applied for quantitative determination of valsartan in tablet dosage form.

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