Sureja D.,Sumandeep Vidyapeeth |
Dholakia S.,Shankersinh Vaghela Bapu Institute of Pharmacy |
Vadalia K.,Atmiya Institute of Pharmacy
Journal of Pharmacy and Bioallied Sciences | Year: 2016
Objectives: The aim of the present work was to synthesize a novel series of pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives and evaluate their in vitro antimicrobial activity. Methods: Cyclization of an ortho-amino ester of 1-(2,4-dinitrophenyl)pyrazole with various aliphatic/aromatic nitriles under different reaction conditions such as conventional and microwave assisted synthesis, provided pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives. All the synthesized compounds were evaluated in vitro for their antimicrobial activity against selected bacteria and fungi by agar well diffusion method. Results: All newly synthesized compounds were characterized using spectral and elemental analysis. Compounds 2e, 2f, and 2g showed significant antimicrobial activity as compared to standard drugs used. Conclusion: The newly synthesized compounds could be useful templates for the design and optimization of more active analogs as a possible antimicrobial agent. © 2017 Journal of Pharmacy and Bioallied Sciences | Published by Wolters Kluwer - Medknow.
Maheshwari R.A.,Sumandeep Vidyapeeth |
Khatri S.,Sumandeep Vidyapeeth |
Balaraman R.,Sumandeep Vidyapeeth |
Seth A.K.,Sumandeep Vidyapeeth
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014
Objective: The objective of the study was aimed to investigate the antidiabetic activity of Dibolin (a polyherbal formulation) in streptozotocin-nicotinamide induced type 2 diabetic rats. Methods: Oral glucose tolerance test (OGTT) was performed to evaluate Dibolin effect on elevated glucose level. The type 2 diabetes was induced by overnight fasted rats by a single intraperitoneal (i.p.) injection of 65 mg/kg streptozotocin, 15 min. after the i.p. administration of 110 mg/kg nicotinamide. The diabetic rats were treated with Dibolin (500 and1000 mg/kg, p.o.) or glibenclamide (5 mg/kg, p.o) for four week. Various parameters were studied included fasting blood sugar level, serum insulin levels, glycated hemoglobin (HbA1C), serum lipid levels, AST, ALT, serum creatinine, urea, uric acid. Results: Treatment with Dibolin significantly reduced blood sugar levels in OGTT. Diabetic rats showed a significant increase in the levels of glycated hemoglobin, serum lipids, AST, ALT, serum creatinine, urea and uric acid, whereas there was a significant decrease in Hb, serum insulin and HDL-C levels as compared to normal control rats. The administration of Dibolin or glibenclamide significantly decreased the levels of glycated hemoglobin, TG, TC, LDL-C, AST, ALT, serum creatinine, urea and uric acid, whereas there was a significant increase in the level of Hb, serum insulin and HDL-C as compared to diabetic control rats. Conclusion: These results concluded that Dibolin caused antidiabetic and antihyperlipidemic activities which are responsible for its use in traditional medicine.
Yadav Y.C.,Sumandeep Vidyapeeth
Brazilian Journal of Pharmacognosy | Year: 2015
Ficus religiosa L., Moraceae, is widely planted in the tropics. The chemical constituents of F. religiosa includetannin, saponin gluanol acetate, β-sitosterol, leucoanthocyanidin, and leucoanthocyanin. These are usedfor the treatment of pain, inflammation, impotence, menstrual disturbances, and urine related problems,and as uterine tonic. The present study aimed to evaluate hepatoprotective effects of F. religiosa latex oncisplatin induced liver injury in Wistar rats. In experimental protocol contained five groups of rats (n = 6).In which, group I (control) was administered acacia (2%, w/v) of 5 ml/kg throughout the experimentfor 16 days. The group II (cisplatin treated) was administered single dose of cisplatin (7.5 mg/kg i.p.)on 1stday. Group III (extract control) was administered 300 mg/kg p.o. of extract for 1stto 10thday.Group IV (Protective) was administered extract (300 mg/kg p.o.) of F. religiosa latex for 1stto 10thdayand administered single dose of cisplatin (7.5 mg/kg i.p.) on 11thday and group V (Curative) receivedsingle dose of cisplatin (7.5 mg/kg i.p.) on day 1st, and administered extract (300 mg/kg p.o.) from 7thto 16thdays. On the 6thday in cisplatin treated, 10thday in extract control and 16thday in control,protective and curative, blood withdrawn from retro-orbital sinus of rats for biochemical estimation forserum and dissected out the livers for estimation of antioxidant enzymes and histopathological works.The cisplatin-treated group 2 showed a significant increase in serum alanine aminotransferase, aspartateaminotransferase, alkaline phosphatase and hepatocytes cells degeneration inflammatory infiltrate andnecrosis it’s were significantly (**p < 0.01) alleviates by protective groups. © 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.
Sheth N.S.,Sigma Institute of Pharmacy |
Shah N.V.,Sumandeep Vidyapeeth |
Shah N.C.,Sumandeep Vidyapeeth
Journal of Global Pharma Technology | Year: 2010
Plant products serve as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower prices compare to important synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. The present study was undertaken to separate mucilage from the seeds of Ocimum americanum linn and explore its use as a tablet disintegrant. Method for extraction of mucilage from the seeds was developed and it was separated. The separated mucilage was evaluated for various parameters as per Indian pharmacopoeia. The disintegrating efficiency of separated mucilage was compared with that of the starch in tablets prepared using lactose, Paracetamol and poly vinyl pyrrolidone as model diluent, drug and binder respectively. The disintegration time for tablet formulations prepared using mucilage was less then that was prepared by using starch as a disintegrant. © 2009, JGPT.
Yadav Y.C.,Sumandeep Vidyapeeth
Pharmaceutical Biology | Year: 2013
Context. Ficus religiosa L. (Moraceae) is widely planted in the tropics. Its chemical constituents include tannin, saponin gluanol acetate, β-sitosterol, leucoanthocyanidin and leucoanthocyanin which are used for the treatment of pain, inflammation, impotence, menstrual disturbances, uterine tonic and urine related problems. Objective: To determine the possible nephroprotective and curative effects of F. religiosa latex methanol extract against cisplatin induced acute renal failure. Materials and methods: Methanol extract was obtained by maceration process. Rats were divided in five groups. Group 1 was administered acacia (2% w/v) of 5ml/kg throughout the experiment; group 2 was treated with single dose of cisplatin (5mg/kg i.p.) on the 1st day; group 3 (200mg/kg p.o.) of extract control for the 1st to 10th day, group 4 (200mg/kg p.o.) of extract from the 1st to 10th day and a single dose of cisplatin (5mg/kg, i.p.) on 11th day while group 5 received the same dose of cisplatin on day 1 and extract (200mg/kg p.o.) from the 7th to 16th day. Results: Phytochemical screening of the extract revealed the presence of glycoside, alkaloids, tannins (phenolic compounds), flavonoids and amino acids. The half maximal inhibitory concentration (IC50) values of the extract were 31.75±0.12 and 18.35±0.48μg/ml, respectively. The cisplatin-treated group 2 showed significant changes; renal functions, biochemical parameters and histopathology were significantly (**p<0.01) recovered by 200mg/kg curative and protective groups. Discussion and conclusion: These findings demonstrated that F. religiosa latex and constituents have excellent nephroprotective and curative activities and thus have great potential as a source for natural health products. © 2013 Informa Healthcare USA, Inc.
Schoonover J.,Mount Sinai School of Medicine |
Lipkin S.,New York University |
Javid M.,Mount Sinai School of Medicine |
Rosen A.,Mount Sinai School of Medicine |
And 3 more authors.
Annals of Global Health | Year: 2014
Background Despite the significant toll of mental illness on the Indian population, resources for patients often are scarce, especially in rural areas. Traditional healing has a long history in India and is still widely used, including for mental illnesses. However, its use has rarely been studied systematically. Objective The aim of this study was to determine the perspective of patients, their families, and healthy community members toward faith healing for mental illness, including the type of interventions received, perceptions of its efficacy, and overall satisfaction with the process. We also sought to explore the range of care received in the community and investigate possibilities for enhancing mental health treatment in rural Gujarat. Methods We interviewed 49 individuals in July 2013 at Dhiraj General Hospital and in 8 villages surrounding Vadodara. A structured qualitative interview elicited attitudes toward faith healing for mental illnesses and other diseases. Qualitative analysis was performed on the completed data set using grounded theory methodology. Findings Subjects treated by both a doctor and a healer reported they overwhelmingly would recommend a doctor over a healer. Almost all who were treated with medication recognized an improvement in their condition. Many subjects felt that traditional healing can be beneficial and believed that patients should initially go to a healer for their problems. Many also felt that healers are not effective for mental illness or are dishonest and should not be used. Conclusions Subjects were largely dissatisfied with their experiences with traditional healers, but healing is still an incredibly common first-line practice in Gujarat. Because healers are such integral parts of their communities and so commonly sought out, collaboration between faith healers and medical practitioners would hold significant promise as a means to benefit patients. This partnership could improve access to care and decrease the burden of mental illness experienced by patients and their communities. © 2014 Icahn School of Medicine at Mount Sinai.
Lakhani S.J.,Sumandeep Vidyapeeth |
Lakhani O.J.,Sir Ganga Ram Hospital
BMJ Case Reports | Year: 2015
PIBIDS syndrome (photosensitivity, ichthyosis, brittle hair, intellectual impairment, decreased fertility and short stature) is a variant of trichothiodystrophy. It is a rare form of autosomal recessive congenital ichthyosis. Short stature is a vital component of PIBIDS syndrome. We present the cases of two siblings in whom we diagnosed PIBIDS syndrome. On evaluation for short stature, they were found to have severe vitamin D deficiency, which on correction led to the patients having considerable gain in stature. With this case, we would also like to propose that vitamin D deficiency could be one of the treatable causes of short stature in PIBIDS syndrome.
Maheshwari R.,Sumandeep Vidyapeeth |
Sailor G.,Sumandeep Vidyapeeth |
Patel L.,Zydus Research Center |
Balaraman R.,Sumandeep Vidyapeeth
Indian Journal of Pharmacology | Year: 2013
Objectives: This study aimed to investigate the protective effect of simvastatin (SIM) and rosuvastatin (RST) on cisplatin (CIS)-induced nephrotoxicity. Materials and Methods: Adult female Wistar rats were divided into six groups: Control group (Group 1) received 0.5% sodium carboxy methyl cellulose, group 2 and group 3 received SIM and RST for 10 days, respectively, and group 4 was injected single dose of CIS (7 mg/kg, i.p.). Group 5 and 6 were treated with SIM (10 mg/kg, p.o.) and RST (10 mg/kg, p.o.) for 10 days, respectively. All groups received cisplatin on the 5 th day of treatment. Renal function tests like serum creatinine, urea, BUN, albumin, calcium, uric acid and magnesium, serum lipids, and markers of oxidative stress such as renal malondialdehyde (MDA) level and superoxide dismutase (SOD) and catalase (CAT) activities were measured. All tissues were investigated for histopathological changes. Result: CIS reduced the renal function, which was reflected with significant increase in serum urea, BUN, serum creatinine, uric acid and also significant decrease serum calcium, magnesium, albumin levels. In addition, cisplatin caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity, and elevation of serum lipids. SIM or RST ameliorate CIS induced renal damage due to improvement in renal function, oxidative stress, suppression of serum lipids, and histological alteration. Conclusions: This finding suggests that simvastatin and rosuvastatin may have a protective effect against cisplatin-induced kidney damage via amelioration of lipid peroxidation as well as due to improvement of renal function, and lipid-lowering effects.
Muley P.,Sumandeep Vidyapeeth |
Shah M.,Km Shah Dental College |
Muley A.,Sumandeep Vidyapeeth
Current Drug Safety | Year: 2013
Context and Aim: Asthma is a common problem in paediatric population. International treatment guidelines recognize the role of inhaled corticosteroids for asthma in young children. Inhaled fluticasone propionate is reported to have greater systemic effects like other corticosteroids. Limited data is available on safety of this drug when used for longer duration. So, we conducted a systematic review to study the effect of inhaled fluticasone propionate on adrenal suppression, growth and bone mineral density in paediatric patients. Design: A systematic review. Methods: We searched for Randomized controlled trials in MEDLINE from January 2000 to December 2012. References of included study were hand searched. Information on study design, study population, drugs and dosage used, follow up period, measures used to evaluate safety and outcomes was abstracted independently by three reviewers. Details of Included Studies: In all included studies, participants were asthmatic children below 18 years and treated with fluticasone propionate. Minimum follow up considered was three months and should have measured HPA suppression or growth velocity or bone mineral density. Results: Total ten studies were included. Studies which had monitored HPA function varied in dosage of drug, mode of administration and duration. Inspite of that it has been observed that serum cortisol level is affected by fluticasone propionate, no significant effect on bone mineral density was reported with fluticasone propionate, but the sample size was inadequate and dietary calcium intake was not recorded. None of the studies reported any significant reduction in growth when inhaled fluticasone propionate was used for the treatment of asthma, but the baseline growth and final adult height attained were not assessed. Limitation: This systematic review included only free full text articles published in English. Only randomized controlled trials were included. Cohort studies were not included. Conclusion: With available evidences, the safety of inhaled fluticasone propionate cannot be questioned. This systematic review could not derive any significant adverse effect on HPA function, growth and bone mineral density in asthmatic children when used for long duration and followed for up to three months. © 2013 Bentham Science Publishers.
Maheshwari R.A.,Sumandeep Vidyapeeth |
Balaraman R.,Sumandeep Vidyapeeth |
Sen A.K.,Sumandeep Vidyapeeth |
Seth A.K.,Sumandeep Vidyapeeth
Indian Journal of Pharmacology | Year: 2014
Objectives: This study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with metformin on streptozotocin (STZ)-nicotinamide-induced diabetic nephropathy (DN). Materials and Methods: Type 2 diabetes in rats was induced with STZ-nicotinamide. The diabetic rats were treated with coenzyme Q10 (10 mg/kg, p.o.) alone or coenzyme Q10 + metformin. Various parameters of renal function tests such as serum creatinine, urea, uric acid, and markers of oxidative stress such as renal malondialdehyde (MDA) level, superoxide dismutase (SOD), and catalase (CAT) activities were measured. Tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) activity, transforming growth factor-β (TGF-β), and nitrite content were estimated in renal tissues. All treated animal were subjected to histopathological changes of kidney. Result: Diabetic rats showed a significant reduction in renal function, which was reflected with an increase in serum urea, serum creatinine, uric acid. In addition, STZ-nicotinamide caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity and glutathione (GSH) level. Moreover, TNF-α, MPO activity, TGF-β, and nitrite content were significantly increased in diabetic rats, while treatment with coenzyme Q10 or metformin or their combination ameliorate STZ-nicotinamide induced renal damage due to improvement in renal function, oxidative stress, suppression of TNF-α, MPO activity, TGF-β and nitrite content along with histopathological changes. Conclusions: This finding suggests that the treatment with coenzyme Q10 or metformin showed significant renoprotective effect against STZ-nicotinamide-induced DN. However, concomitant administration of both showed a better renoprotective effect than coenzyme Q10 or metformin alone treatment.