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Vadodara, India

Schoonover J.,Mount Sinai School of Medicine | Lipkin S.,New York University | Javid M.,Mount Sinai School of Medicine | Rosen A.,Mount Sinai School of Medicine | And 3 more authors.
Annals of Global Health | Year: 2014

Background Despite the significant toll of mental illness on the Indian population, resources for patients often are scarce, especially in rural areas. Traditional healing has a long history in India and is still widely used, including for mental illnesses. However, its use has rarely been studied systematically. Objective The aim of this study was to determine the perspective of patients, their families, and healthy community members toward faith healing for mental illness, including the type of interventions received, perceptions of its efficacy, and overall satisfaction with the process. We also sought to explore the range of care received in the community and investigate possibilities for enhancing mental health treatment in rural Gujarat. Methods We interviewed 49 individuals in July 2013 at Dhiraj General Hospital and in 8 villages surrounding Vadodara. A structured qualitative interview elicited attitudes toward faith healing for mental illnesses and other diseases. Qualitative analysis was performed on the completed data set using grounded theory methodology. Findings Subjects treated by both a doctor and a healer reported they overwhelmingly would recommend a doctor over a healer. Almost all who were treated with medication recognized an improvement in their condition. Many subjects felt that traditional healing can be beneficial and believed that patients should initially go to a healer for their problems. Many also felt that healers are not effective for mental illness or are dishonest and should not be used. Conclusions Subjects were largely dissatisfied with their experiences with traditional healers, but healing is still an incredibly common first-line practice in Gujarat. Because healers are such integral parts of their communities and so commonly sought out, collaboration between faith healers and medical practitioners would hold significant promise as a means to benefit patients. This partnership could improve access to care and decrease the burden of mental illness experienced by patients and their communities. © 2014 Icahn School of Medicine at Mount Sinai. Source

Sureja D.K.,Sumandeep Vidyapeeth | Dholakia S.P.,Shankersinh Vaghela Bapu Institute of Pharmacy | Vadalia K.R.,Atmiya Institute of Pharmacy
Der Pharma Chemica | Year: 2016

The present investigation is focused on one pot synthesis of 6-amino-5-cyano-4-substituted-2-(hydroxy/mercapto) pyrimidine derivatives with the objective of discovering a novel and potent anti-inflammatory and antioxidant agent. The formation of compounds was recognized by preliminary laboratory techniques like melting point, Rf value and further confirmed by spectral analysis. Furthermore, they were screened in-vitro to study their anti-inflammatory and antioxidant activity, which shows moderate to good potency. Source

Lakhani S.J.,Sumandeep Vidyapeeth | Lakhani O.J.,Sir Ganga Ram Hospital
BMJ Case Reports | Year: 2015

PIBIDS syndrome (photosensitivity, ichthyosis, brittle hair, intellectual impairment, decreased fertility and short stature) is a variant of trichothiodystrophy. It is a rare form of autosomal recessive congenital ichthyosis. Short stature is a vital component of PIBIDS syndrome. We present the cases of two siblings in whom we diagnosed PIBIDS syndrome. On evaluation for short stature, they were found to have severe vitamin D deficiency, which on correction led to the patients having considerable gain in stature. With this case, we would also like to propose that vitamin D deficiency could be one of the treatable causes of short stature in PIBIDS syndrome. Source

Context. Ficus religiosa L. (Moraceae) is widely planted in the tropics. Its chemical constituents include tannin, saponin gluanol acetate, β-sitosterol, leucoanthocyanidin and leucoanthocyanin which are used for the treatment of pain, inflammation, impotence, menstrual disturbances, uterine tonic and urine related problems. Objective: To determine the possible nephroprotective and curative effects of F. religiosa latex methanol extract against cisplatin induced acute renal failure. Materials and methods: Methanol extract was obtained by maceration process. Rats were divided in five groups. Group 1 was administered acacia (2% w/v) of 5ml/kg throughout the experiment; group 2 was treated with single dose of cisplatin (5mg/kg i.p.) on the 1st day; group 3 (200mg/kg p.o.) of extract control for the 1st to 10th day, group 4 (200mg/kg p.o.) of extract from the 1st to 10th day and a single dose of cisplatin (5mg/kg, i.p.) on 11th day while group 5 received the same dose of cisplatin on day 1 and extract (200mg/kg p.o.) from the 7th to 16th day. Results: Phytochemical screening of the extract revealed the presence of glycoside, alkaloids, tannins (phenolic compounds), flavonoids and amino acids. The half maximal inhibitory concentration (IC50) values of the extract were 31.75±0.12 and 18.35±0.48μg/ml, respectively. The cisplatin-treated group 2 showed significant changes; renal functions, biochemical parameters and histopathology were significantly (**p<0.01) recovered by 200mg/kg curative and protective groups. Discussion and conclusion: These findings demonstrated that F. religiosa latex and constituents have excellent nephroprotective and curative activities and thus have great potential as a source for natural health products. © 2013 Informa Healthcare USA, Inc. Source

Muley P.,Sumandeep Vidyapeeth | Shah M.,Km Shah Dental College | Muley A.,Sumandeep Vidyapeeth
Current Drug Safety | Year: 2013

Context and Aim: Asthma is a common problem in paediatric population. International treatment guidelines recognize the role of inhaled corticosteroids for asthma in young children. Inhaled fluticasone propionate is reported to have greater systemic effects like other corticosteroids. Limited data is available on safety of this drug when used for longer duration. So, we conducted a systematic review to study the effect of inhaled fluticasone propionate on adrenal suppression, growth and bone mineral density in paediatric patients. Design: A systematic review. Methods: We searched for Randomized controlled trials in MEDLINE from January 2000 to December 2012. References of included study were hand searched. Information on study design, study population, drugs and dosage used, follow up period, measures used to evaluate safety and outcomes was abstracted independently by three reviewers. Details of Included Studies: In all included studies, participants were asthmatic children below 18 years and treated with fluticasone propionate. Minimum follow up considered was three months and should have measured HPA suppression or growth velocity or bone mineral density. Results: Total ten studies were included. Studies which had monitored HPA function varied in dosage of drug, mode of administration and duration. Inspite of that it has been observed that serum cortisol level is affected by fluticasone propionate, no significant effect on bone mineral density was reported with fluticasone propionate, but the sample size was inadequate and dietary calcium intake was not recorded. None of the studies reported any significant reduction in growth when inhaled fluticasone propionate was used for the treatment of asthma, but the baseline growth and final adult height attained were not assessed. Limitation: This systematic review included only free full text articles published in English. Only randomized controlled trials were included. Cohort studies were not included. Conclusion: With available evidences, the safety of inhaled fluticasone propionate cannot be questioned. This systematic review could not derive any significant adverse effect on HPA function, growth and bone mineral density in asthmatic children when used for long duration and followed for up to three months. © 2013 Bentham Science Publishers. Source

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