Bardstown, KY, United States

Sullivan University
Bardstown, KY, United States

Sullivan University is licensed to offer bachelor's, master's and doctoral degrees by the Kentucky Council on Postsecondary Education in accordance with the provisions of KRS 164.945-164.99, based in Louisville, Kentucky and is accredited by the Southern Association of Colleges and Schools—the first for-profit college or university to receive this accreditation. Sullivan University currently has physical campuses in Louisville, Lexington, and Fort Knox, and an online campus. With approximately 6,000 students, Sullivan is Kentucky's largest private university. Wikipedia.

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Combs B.L.,Sullivan University | Cox A.G.,Sullivan University
Neuropsychiatric Disease and Treatment | Year: 2017

Parkinson’s disease (PD) has a prevalence of nearly 1 million people in the USA, with increasing incidence in the elderly population. Generally, the age of presentation is between 55 and 65 years, with the likelihood of diagnosis increasing as patients reach the age of 80 years or above. Some of the common treatments for PD increase dopamine levels in the brain. Dopaminergic therapy helps to improve motor and non-motor symptoms, but it is not without risks. Dopaminergic therapy can cause confusion, delirium, and psychotic-like behavior. It is recommended that these agents are used cautiously in patients with a history of psychosis due to the risk of exacerbation. It is unclear whether Parkinson’s disease psychosis (PDP) is due to the disease itself, the treatment, or a combination of both, but it is clear that a safe, effective treatment is necessary. Second-generation (atypical) antipsychotics are the current choice of therapy for PDP. All of these agents have a black box warning from the US Food and Drug Administration (FDA) for elevated risk of mortality in elderly patients with dementia-related psychosis. Pimavanserin (Nuplazid®) received its novel drug approval by the FDA on April 29, 2016, to treat hallucinations and delusions associated with psychosis experienced by some people with PD. We review in this article the new research that led to this approval as well as its potential place in therapy. © 2017 Combs and Cox.

Palmer E.C.,Sullivan University | Binns L.N.,Southern Arizona Veterans Affairs Healthcare System | Carey H.,Louis Stokes Cleveland Veterans Affairs Medical Center
Annals of Pharmacotherapy | Year: 2014

Objective: To provide a clinical overview of the antidepressant levomilnacipran. Data Sources: Articles were identified by searching the MEDLINE, PubMed, Cochrane Library, and databases through March 2014 using the keyword levomilnacipran. The manufacturer provided additional information from unpublished phase II and phase III trials. Study Selection and Data Extraction: Any clinical trial conducted for at least 3 weeks and published in the English language was selected for review. Additional documentation, including the product dossier, package insert, pharmacokinetic studies, and poster presentations supplied by the manufacturer, was also evaluated. Data Synthesis: Levomilnacipran is the more potent enantiomer of milnacipran. It is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), dosed from 20 to 120 mg daily for the treatment of major depressive disorder (MDD). Efficacy and tolerability were established during 3 phase III randomized, double-blind placebo-controlled trials finding levomilnacipran to be significantly more efficacious than placebo in reduction of Montgomery-Åsberg Depression Rating Scale scores. It is not known whether this agent is more efficacious than other antidepressants because direct comparison studies have not been conducted as of the time of this review. Conclusions: Levomilnacipran demonstrates efficacy and tolerability for short-term treatment of MDD in adults. Available evidence does not strongly indicate that there is a specific subpopulation of patients who would benefit from levomilnacipran over currently available SNRIs. Full characterization of the agent's place in therapy alongside multiple other agents with similar mechanisms and efficacy requires trials with longer duration and active comparators. © The Author(s) 2014.

BACKGROUND: Recent changes in the United States (US) economy have radically disrupted revenue generation among many institutions within higher education within the US. Chief among these disruptions has been fallout associated with the financial crisis of 2008-2009, which triggered a change in the US higher education environment from a period of relative munificence to a prolonged period of scarcity. The hardest hit by this disruption have been smaller, less wealthy institutions which tend to lack the necessary reserves to financially weather the economic storm. Interestingly, a review of institutional effectiveness among these institutions revealed that while many are struggling, some institutions have found ways to not only successfully cope with the impact of declining revenue, but have been able to capitalize on the disruption and thrive. OBJECTIVE: Organizational response is an important factor in successfully coping with conditions of organizational decline. The study examined the impacts of organizational response on institutional effectiveness among higher education institutions experiencing organizational decline. The study's research question asked why some US higher educational institutions are more resilient at coping with organizational decline than other institutions operating within the same segment of the higher education sector. More specifically, what role does organizational resilience have in helping smaller, private non-profit institutions cope and remain effective during organizational decline? PARTICIPANTS: A total of 141 US smaller, private non-profit higher educational institutions participated in the study; specifically, the study included responses from participant institutions' key administrators. METHODS: 60-item survey evaluated administrator responses corresponding to organizational response and institutional effectiveness. Factor analysis was used to specify the underlying structures of rigidity response, resilience response, and institutional effectiveness. Multiple regression analysis was used to examine the direct and interaction effects between organizational decline, organizational rigidity response, organizational resilience response, and institutional effectiveness, controlling for age of institution and level of endowment. RESULTS: The study validated previous threat-rigidity response findings that organizational decline alone does not adversely impact institutional effectiveness. The direct effect of Goal-Directed Solution Seeking and Role Dependency organizational resilience factors had a positive, significant correlation with the Student Personal Development institutional effectiveness factor. The interactive effect of Goal-Directed Solution Seeking organizational resilience factor during organizational decline had a positive, significant correlation with the Professional Development and Quality of Faculty institutional effectiveness factor. The interactive effect of Avoidance during organizational decline had a positive, significant correlation with the Faculty and Administrator Employment Satisfaction institutional effectiveness factor. The interactive effect of Diminished Innovation, Morale, and Leader Credibility rigidity response factor and Avoidance organizational resilience factor during organizational decline had a positive, significant correlation with the Professional Development and Quality of Faculty institutional effectiveness factor. Lastly, the interactive effect of Increased Scapegoating of Leaders, Interest group Activities, and Conflict rigidity response factor and Avoidance organizational resilience factor during organizational decline had a positive, significant correlation with the Faculty and Administrator Employment Satisfaction institutional effectiveness factor. CONCLUSIONS: Factors of organizational resilience were found to have a positive effect among smaller, private non-profit higher educational institutions associated with this study toward sustaining institutional effectiveness during organizational decline. Specifically, the organizational resilience factors of Goal-Directed Solution Seeking (i.e., mission-driven solutions) and Avoidance (i.e., skepticism toward new ideas) play a significant, collaborative role among smaller, private non-profit higher educational institutions when it comes to sustaining institutional effectiveness during organizational decline. © 2016 - IOS Press and the authors.

Prasad-Reddy L.,Sullivan University
U.S. Pharmacist | Year: 2012

It is estimated that 14% of girls and 7% of boys aged 9 to 14 years exhibit behavioral patterns reflective of eating disorders. The Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (DSM-IV), further divides eating disorders into three distinct diagnoses-anorexia, bulimia, and eating disorder not otherwise specified-??based on clinical characteristics, behavioral patterns, and symptoms. Unfortunately, many individuals exhibiting disordered eating patterns fail to seek appropriate treatment, leading to a multitude of complications affecting all organ systems. As a result, eating disorders carry the highest mortality rate-??approaching 20%-??of all psychiatric illnesses. Young adults with diabetes are at increased risk for developing psychiatric comorbidities, including eating disorders, because of the complex nature of chronic disease management as well as the effects of chronic disease on psychosocial functioning. The presence of psychiatric comorbidity can lead to suboptimal glycemic management and disease.4This article will discuss the dynamic nature of eating disorders in type 1 diabetes mellitus (T1DM) patients, including clinical features, consequences, and management.

Le U.M.,Sullivan University
IFMBE Proceedings | Year: 2015

Gemcitabine is utilized as the first-line treatment for adenocarcinoma of the pancreas that has been considered as one of the most challenging diseases. The major drawback of the gemcitabine formulations is its high hydrophilicity and short half-life. To compensate for those shortcomings, a large dose of infused gemcitabine is usually used to achieve the desire therapeutic effects. However, using this dose, could lead to a high toxicity and severe adverse effects. Hence, there has been a great of interest in the development of gemcitabine to increase the hydrophobicity, half-life, and stability of the drug. In this review, we summarize the latest approaches in drug delivery of gemcitabine to clarify the unsolved problems of drug resistance and discuss the effectiveness of the advanced delivery systems on different types of cancer. © Springer International Publishing Switzerland 2015.

Carter B.,Sullivan University
Proceedings - 2014 Annual Global Online Conference on Information and Computer Technology, GOCICT 2014 | Year: 2014

In this paper, a very compelling proposition is presented, a novel approach for web development that is a hybrid of Single Page Applications (SPA) and server side applications. The proposed architecture lowers the entry to web development by providing a simplistic approach for development. The focus is on HTML, Java Script, Cascading Style Sheets, and Node.js. The architecture provides all the components required for students to start developing web applications and web services. The HTML Architecture, a Novel Development System (HANDS) is a hybrid approach leveraging the simplicity of plain old HTML pages, the AJAX injection of HTML from SPA frameworks, and the server side processing found in the Node.js framework. An open source starter kit and examples are provided. © 2014 IEEE.

Carter B.,Sullivan University
Proceedings - 2014 Annual Global Online Conference on Information and Computer Technology, GOCICT 2014 | Year: 2014

In this paper, a very compelling proposition is presented, a portable system for software development. The focus is on HTML, Java Script, CSS, Node.js, and SQLite. The system provides all the applications required for students to start developing web applications. The HTML Educational Node.js System (HENS) does not require installation or admin access allowing for portability. This environment is built using open source applications. © 2014 IEEE.

Wagner C.P.,Sullivan University | Wahl D.H.,Sullivan University
Fisheries Management and Ecology | Year: 2011

Intraspecific, seasonal and diel variation in movement behaviours of three stocks of juvenile (age-2; 399-610mm total length) muskellunge, Esox masquinongy Mitchill, were assessed using radio telemetry in Forbes Lake (225ha), IL, USA. Experimental populations included muskellunge from the Upper Mississippi (Leech Lake, MN, USA) and Ohio (Cave Run Lake, KY, USA) river drainages, as well as progeny from North Spring Lake, IL, a mixed-origin stock. No differences in hourly movement rates or home ranges were detected among stocks. Movement rates were greatest during spring (mean±SE=42±4mh -1), lowest during summer (16±3mh -1) and intermediate in autumn (28±5mh -1). Additionally, movement rates during the summer were greater at night than crepuscular periods. Home range sizes were similar during spring and autumn (mean±SE=17-18±3-4ha) and decreased during summer (5±3ha). Although habitat selection characteristics were generally similar among stocks, fish from the Upper Mississippi River drainage occupied deeper water more frequently and selected the pelagic zone more strongly during the spring than those from the Ohio River and mixed-origin stocks. Within the littoral zone, muskellunge selected coarse woody habitat and aquatic macrophytes. Collectively, these findings suggest little behavioural differentiation among genetically divergent stocks when evaluated in a common reservoir environment. © 2011 Blackwell Publishing Ltd.

Todd R.,Sullivan University
Dental Clinics of North America | Year: 2014

Cone beam computed tomography has gained acceptance in the endodontic community for assistance with diagnosis, treatment, and evaluation of outcomes. This article reviews a multitude of applications, from basic principles to clinical applications, using specific cases and supporting literature to demonstrate the benefits for both the specialist and general practitioner. © 2014 Elsevier Inc.

Sullivan T.D.,Sullivan University
Geologically Active - Proceedings of the 11th IAEG Congress | Year: 2010

The Geological Model is the fundamental basis for all geotechnical analysis and design. Notwithstanding this there is very little information available that describes what The Geological Model is, what it should contain and how to formulate an effective model. This paper brings together the understanding, concepts, ideas and processes developed over more than 35 years of making geological models. The fundamental problem with anything built from geology, are the gaps and the limited vision. This leads to uncertainty and risk, which can only be successfully managed with sound geological models. The lessons from cognitive science and psychology about the way the brain functions provide powerful insights into the thinking processes and skills required to develop good geological models. These are supplemented by reinforcement of the essential role of the scientific method, inductive reasoning, education and mentoring. The general principles guiding geological models are presented and the problems normally associated with poor models highlighted. Guidelines and frameworks for developing sound geological models are presented together with the key questions that need to be answered at each stage of the process. © 2010 Taylor & Francis Group, London.

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