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Shui L.,Chongqing Medical University | Mao S.,Chongqing Three Gorges University | Wu Q.,Fuling Central Hospital | Huang G.,Chongqing Medical University | And 9 more authors.
Ultrasonics Sonochemistry | Year: 2015

Abstract Objective To evaluate the long-term improvement of clinical symptoms of adenomyosis after treatment with ultrasound-guided high intensity focused ultrasound (USgHIFU). Methods From January 2010 to December 2011, 350 patients with adenomyosis were treated with USgHIFU. Among the 350 patients, 224 of them completed the two years follow-up. The patients were followed up at 3 months, 1 year, and 2 years after HIFU treatment. Adverse effects and complications were recorded. Results All patients completed HIFU ablation without severe postoperative complications. 203 of the 224 patients who showed varying degrees of dysmenorrhea before treatment had the symptom scores decreased significantly after treatment (P < 0.001). The relief rate was 84.7%, 84.7%, and 82.3%, respectively at 3 months, 1 year, and 2 years after treatment. The menstrual volume in 109 patients with menorrhagia was significantly improved after treatment (P < 0.001) with a relief rate of 79.8%, 80.7%, and 78.9%, respectively at 3 months, 1 year, and 2 years after HIFU treatment. Conclusion With its ability to sustain long-term clinical improvements, HIFU is a safe and effective treatment for adenomyosis. © 2015 Elsevier B.V.

Zeng C.,Suining Central HospitalSichuan | Tang S.,Suining Central HospitalSichuan | Jiang Y.,Suining Central HospitalSichuan | Xiong X.,Suining Central HospitalSichuan | Zhou S.,Kunming University of Science and Technology
International Journal of Clinical and Experimental Medicine | Year: 2015

In the present study, 7 patients with brain hemorrhage combined with intracranial tumor were investigated for about 3 years. Furthermore, the previous reports related with such cases were also reviewed. In all of these patients, hemorrhage was a main characteristic of the diagnosed neoplasm. The clinical data were identified by computed tomography (CT) scanning in the present study. CT scanning results demonstrated that there was a neoplastic core with high or low density and multifocal clots generally at the borders of the tumors. Increase of tumor tissues with intravenous injection of approximate 70% hypaque was analyzed in all the 7 patients with brain hemorrhage. The parts that were increased showed peripheral distributions corresponding to the hemorrhage sites. In conclusion, the intracranial brain hemorrhage related with the several types of tumors, including hemangiopericytoma, metastatic carcinomas, oligodendroglioma, and glioblastoma multiforme, which may be helpful to these patients. © 2015, E-Century Publishing Corporation. All Rights Reserved.

Wu Y.,Chongqing Medical University | Yu Z.,Chongqing Medical University | Gong J.,Chongqing Medical University | Li M.,Suining Central HospitalSichuan | Liu Y.,Chongqing Medical University
Annals of Hepatology | Year: 2016

Background and rationale for the study. Previous studies showed that CTLA4Ig and indoleamine 2,3-dioxygenase (IDO) genes played regulatory role in organ transplantation but failed to reach satisfactory effects. In this study, we constructed an adenovirus-mediated gene expressing CTLA4Ig–IDO and established rat liver transplantation models. Recipients were randomly divided into four groups of 10 rats each. During the operation, CTLA4Ig, IDO, and CTLA4Ig–IDO genes, as well as a blank plasmid, were infused into different rat groups via portal vein to determine their effects on inducing immune tolerance. Survival rate of recipients, histological changes of graft liver, post-transplantation liver function, and cytokine levels were observed at day 14 after operation. Results. Serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST), and total bilirubin level (TBIL) in the CTLA4Ig-IDO group were lower than those in the other three groups at 14 days post-transplantation (P < 0.05); mRNA and protein expressions of IL-2 and IFN-γ were higher in the control group, but lower in the CTLA4Ig-IDO group (P < 0.05). By contrast, expressions of IL-4, TGF-b, IL-10, and T lymphocyte apoptosis were higher in the CTLA4Ig-IDO group than those in the other three groups (P < 0.05). The CTLA4Ig-IDO group exhibited mild acute rejection and higher survival rate compared with the other groups (P < 0.05). Conclusion. Compared with using CTLA4Ig or IDO alone, combined transfection of CTLA4Ig-IDO was more effective in inducing immune tolerance after liver transplantation. © 2016, Fundacion Clinica Medica Sur. All rights resereved.

Luo D.,University of Sichuan | Wu L.,University of Sichuan | Wu H.,Suining Central HospitalSichuan | Huang W.,University of Sichuan | Huang H.,University of Sichuan
International Journal of Clinical and Experimental Medicine | Year: 2015

Gastroschisis requires surgical repair, which is generally performed after birth. We report a case in which a fetus with gastroschisis underwent the abdominal wall defect repair before birth. To ensure reliable operating conditions for the repair (to prevent fetal movement and crying), the fetus received deep anesthesia via placental transfer of maternally administered anesthetics. Meanwhile, the ex utero intrapartum treatment procedure was performed to ensure fetal oxygen supply, which was likely to be compromised by the deep fetal anesthesia. The procedure last for 23 minutes and the gastroschisis was successfully repaired before the neonate was delivered. Maternal hemodynamics was kept stable during this surgical procedure. The prenatal repair of abdominal wall defect is safe for the mother and the fetus, which could potentially improve the neonatal outcomes. © 2015, E-Century Publishing Corporation. All Rights Reserved.

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