Tian B.,Suining Central Hospital of Sichuan Province |
Wu Y.,Suining Central Hospital of Sichuan Province |
Li Q.-F.,Chongqing Medical University |
Song Y.,Chongqing Medical University |
And 5 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2014
Objective To investigate the correlation between FABP2 gene Ala54Thr polymorphism and polycystic ovary syndrome (PCOS), insulin resistance (IR), and glucose and lipid metabolism. Methods The genotypes of FABP2 gene Ala54Thr polymorphism were determined in 135 PCOS patients and 116 normal control subjects by PCR-restriction fragment length polymorphism (PCR-RFLP). At the same time, the anthropometry was performed and metabolism indices were measured. Hyperinsulinemia-euglycemia clamp test was performed in 107 PCOS patients and 20 normal control subjects. Results No significant differences were found in allele frequencies and genotype of FABP2 gene Ala54Thr polymorphism between PCOS and normal control group (P>0.05). Similarly, no significant differences were found in fasting plasma glucose (FPG), 2 hour post-challenge glucose (2hPG), fasting plasma insulin (FINS), homeostasis model assessment 2 (HOMA2-IR), glucose metabolic rate during the euglycemia clamp phase (M120180), free fatty acids (FFA), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) between Thr54Thr, Ala54Thr genotype and Ala54Ala genotype in PCOS group. Conclusion FABP2 gene Ala54Thr polymorphism is not associated with the occurrence of PCOS and IR, and glucose and lipid metabolism.