Suining Central Hospital of Sichuan Province

Suining, China

Suining Central Hospital of Sichuan Province

Suining, China
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Liu Y.,Suining Central Hospital of Sichuan Province | Kong X.,Chongqing Medical University
Cancer Research and Clinic | Year: 2017

Objective: To explore the clinical characteristics and prognostic factors of patients with hepatolithiasis associated with intrahepatic cholangiocarcinoma. Methods: The clinical data of 39 patients with hepatolithiasis associated with intrahepatic cholangiocarcinoma in the First Affiliated Hospital of Chongqing Medical University from Jan 2006 to Jun 2013 was retrospectively analyzed. Results: The main clinical manifestations of hepatolithiasis associated with intrahepatic cholangiocarcinoma included recurrent fever, abdominal pain, jaundice and hepatic percussion pain. Among the 39 cases, the patients older than 60 years accounted for 69.2 % (27/39), and the duration of hepatolithiasis more than 10 years accounted for 76.9 % (30/39). Remarkable differences were found in serum CA19-9 and surgery methods (both P < 0.05). Conclusions Recurrent fever, abdominal pain, jaundice and hepatic percussion pain are the main clinical manifestations for the patients who are diagnosed with hepatolithiasis associated with intrahepatic cholangiocarcinoma. Advanced age and longer duration of the disease may be the high risk factors. Serum CA 19-9 levels and surgical methods are the important prognostic factors.


Tian B.,Suining Central Hospital of Sichuan Province | Wu Y.,Suining Central Hospital of Sichuan Province | Li Q.-F.,Chongqing Medical University | Song Y.,Chongqing Medical University | And 5 more authors.
Medical Journal of Chinese People's Liberation Army | Year: 2014

Objective To investigate the correlation between FABP2 gene Ala54Thr polymorphism and polycystic ovary syndrome (PCOS), insulin resistance (IR), and glucose and lipid metabolism. Methods The genotypes of FABP2 gene Ala54Thr polymorphism were determined in 135 PCOS patients and 116 normal control subjects by PCR-restriction fragment length polymorphism (PCR-RFLP). At the same time, the anthropometry was performed and metabolism indices were measured. Hyperinsulinemia-euglycemia clamp test was performed in 107 PCOS patients and 20 normal control subjects. Results No significant differences were found in allele frequencies and genotype of FABP2 gene Ala54Thr polymorphism between PCOS and normal control group (P>0.05). Similarly, no significant differences were found in fasting plasma glucose (FPG), 2 hour post-challenge glucose (2hPG), fasting plasma insulin (FINS), homeostasis model assessment 2 (HOMA2-IR), glucose metabolic rate during the euglycemia clamp phase (M120180), free fatty acids (FFA), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) between Thr54Thr, Ala54Thr genotype and Ala54Ala genotype in PCOS group. Conclusion FABP2 gene Ala54Thr polymorphism is not associated with the occurrence of PCOS and IR, and glucose and lipid metabolism.

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