Suining Center Hospital

Suining, China

Suining Center Hospital

Suining, China

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Li J.-G.,Affiliated Hospital of Zunyi Medical College | Hu X.,Affiliated Hospital of Zunyi Medical College | Zheng X.-B.,Affiliated Hospital of Zunyi Medical College | Li Y.-J.,Affiliated Hospital of Zunyi Medical College | And 2 more authors.
World Chinese Journal of Digestology | Year: 2015

AIM: To assess the efficacy and safety of totally extraperitoneal prosthetic (TEP) vs Lichtentein tension-free repair of inguinal hernia in adults. METHODS: China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), Wanfang Database, VIP Database, Foreign Medical Journal Full-Text Service (FMJS), PubMed and Cochrane Library were searched for randomized controlled trials (RCTs) comparing the efficacy of TEP vs Lichtentein tension-free repair of inguinal hernia in adults. RevMan 5.1 software was used for meta-analysis. RESULTS: We included 12 prospective randomized controlled trials with 3249 cases. Meta-analysis showed that: (1) operation time: results from 10 studies (n = 2642) showed a significant difference between the TEP group and Lichtenstein group (MD = 6.23, 95%CI: 2.07-10.38, P = 0.003); (2) postoperative complications: results from 10 studies (n = 2740) showed a significant difference between the two groups (OR = 0.56, 95%CI: 0.46-0.69, P < 0.0001); (3) hospital stay: results from 6 studies (n = 348) showed no significant difference between the two groups (MD = -0.84, 95%CI: -1.81-0.13, P = 0.09); (4) time to resumption of normal physical activity: results from 7 studies (n = 2329) showed a significant difference between the two groups (MD = -4.27, 95%CI: -5.58--2.96, P < 0.0001). CONCLUSION: Compared with the Lichtenstein group, the TEP group is associated with significantly reduced postoperative complication and time to resumption of normal physical activity. However, operation time in the Lichtenstein group is significantly lower than that in the TEP group. Larger and high quality studies are needed to verify our findings. © 2015 Baishideng Publishing Group Inc. All rights reserved.


Li X.-X.,Suining Center Hospital | Li Y.-J.,Suining Center Hospital | Liu Y.-H.,Affiliated Hospital of Zunyi Medical College | Liu X.-Y.,Suining Center Hospital
World Chinese Journal of Digestology | Year: 2015

AIM: To assess the impact of reduced preoperative fasting time on safety and efficacy in elective surgical patients. METHODS: Randomized controlled trials (RCTs) of preoperative fasting time in elective surgical patients were searched and retrieved through databases including CNKI, WanFang Data, China Biology Medicine disc (CBM), Foreign Medical Journal Full-Text Service (FMJS), Cochrane Library and PubMed. RevMan 5.1 software was used for Metaanalysis. RESULTS: Seven RCTs involving 1623 patients were included. Meta-analysis showed thatless preoperative hunger (RR = 0.35, 95%CI: 0.23-0.54, P < 0.00001), thirst (RR = 0.25, 95%CI: 0.15-0.40, P < 0.00001), and anxiety (RR = 0.26, 95%CI: 0.09-0.69, P = 0.007) were reported by those who had a shorter fast; however, it could not reduce the incidence of nausea (RR = 0.92, 95%CI: 0.73-1.16, P = 0.49) and vomiting (RR = 0.81, 95%CI: 0.58-1.13, P = 0.23) after the operation. CONCLUSION: Compared with traditional preoperative fasting, implementation of reduced preoperative fasting can reduce preoperative hunger, thirst and anxiety, but has no significant impact on the incidence of postoperative nausea and vomiting. © 2015 Baishideng Publishing Group Inc. All rights reserved.


Zou B.,University of Sichuan | Li T.,Sichuan Provincial Cancer Hospital | Zhou Q.,Suining Center Hospital | Ma D.,North Sichuan Medical College | And 14 more authors.
Medicine (United States) | Year: 2016

To evaluate the treatment pattern and survival of patients receiving radical resection for primary small cell carcinoma of the esophagus (PSCCE). This retrospective study included 150 patients who received radical resection of PSCCE. Data were retrieved from 4 centers in Western China. Thirty-nine of 150 patients received postoperative chemo-radiotherapy, 62 received postoperative chemotherapy, and 49 received radical resection only. The median radiation dosage was 50 Gy. The chemotherapeutic regimen was platinum-based and lasted for 2 to 6 cycles (median, 3). Median disease-free survival (mDFS) and overall survival (mOS) were 12.0 and 18.3 months, respectively. Subgroup analysis revealed that postoperative therapy did not improve survival in limited stage I (LSI) disease, whereas postoperative chemotherapy improved survival in limited stage II (LSII) disease. Relative to chemotherapy alone, chemoradiotherapy did not improve survival in patients with completely resected LSII disease. A multivariate analysis indicated an association of no postoperative chemotherapy with shorter DFS (P = 0.050) and OS (P = 0.010). Higher lymph node stage and length of disease longer than 3 cm were poor prognostic factors for both DFS and OS. Adjuvant chemotherapy improves survival in PSCCE patients with completely resected LSII disease. Adjuvant treatment with postoperative chemotherapy alone or postoperative chemo-radiotherapy does not increase survival in completely resected LSI disease. © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.


Li X.Y.,Traditonal Chinese Medicine Hospital of Dianjiang | Wang M.Y.,Chongqing Medical University | Zhang J.Y.,Chongqing Medical University | Li J.Z.,Chongqing Medical University | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

In this research, we used GdCl3 (gadolinium chloride) to restrain the function of Kupffer cells and assessed effects on hepatocarcinogenesis and metastasis in the Kunming mouse. A 0.25% GdCl3 solution (10 mg/kg b.w.) was infused via the vena caudalis of each mouse 1 week before inoculation of H22 cells and was continued once per three days. Then we observed the follow indexes 3 weeks after injection of H22 cells: tumor weight, histologic characteristics of tumor tissue by light microscopy, ultramicrostructure of Kupffer cells under the electron microscope, distribution and number of Kupffer cells by histochemical staining, and TNF-α and IFN-γ levels in blood-serum and liver tissue by ELISA and RT-PCR. MMP-2 protein expression was tested by immunohistochemistry. The GdCl3 pretreatment had no effect on the quantity of Kupffer cells, but clearly restrained their functions, with decrease of TNF-α and IFN-γ levels and elevation of MMP2. Tumor immunity functions were markedly suppressed and tumor growth was accelerated with appearance of metastasis. Furthermore, survival time of trial mice was shortened.


Zhou Q.,University of Sichuan | Zhou Q.,Suining Center Hospital | Zou B.-W.,University of Sichuan | Xu Y.,University of Sichuan | And 8 more authors.
Tumor Biology | Year: 2015

Polymorphisms in DNA repair genes impact on the synthesis of DNA repair proteins that are crucial to the repair of DNA damages induced by chemotherapy and radiotherapy. We retrospectively examined whether there was an association between the selected six single nucleotide polymorphisms (SNPs) of five DNA repair genes (PARP1-Val762Ala, XRCC1-Arg194Trp, XRCC1-Arg399Gln, XPC-Lys939Gln, BRCA1-Lys1183Arg, and BRCA2-Asn372His) and the clinical outcome of patients with primary small cell carcinoma of esophagus (SCCE), and it showed that the median progression-free survival (PFS) and the overall survival (OS) were 11.8 versus 9.7 months (P = 0.041) and 17.4 versus 14.8 months (P = 0.032) for patients carrying the variant allele (T/C + C/C) and the wild-type allele (T/T) of PARP1-Val762Ala polymorphism, respectively. However, no statistical significance was observed in the other five polymorphic loci (P > 0.05). When these six SNPs were combined, however, patients with at least three variant genotypes had significantly longer PFS and OS compared with those carrying less than three variant genotypes (P = 0.009 and P = 0.007, respectively). The presence of at least three polymorphic variants in certain DNA repair genes may impact on patient survival and could be a potential genomic predictor of clinical response to DNA-damaging treatment in SCCE patients. © 2014, The Author(s).


Yan X.-Y.,Suining Center Hospital | Chen H.-M.,Suining Center Hospital | Tang Z.-J.,Suining Center Hospital
International Journal of Ophthalmology | Year: 2010

• AIM: To compare the recurrent rate in 1 year of three different surgical treatments for pterygium. • METHODS: The patients with pterygium underwent three different surgical treatments after 2008 were analyzed, the recurrent rates were compared, the Chi-square test was used in this study. • RESULTS: There was obvious difference among three different surgical treatments. The recurrence rate was high in pure pterygial resection. but in either pterygium excision with autologous corneal stem cell transplantation or pterygium excision with biological amniotic membrane transplantation surgery, the recurrent rate was low, and these two operations were not statistically significant. • CONCLUSION: Pterygium excision with autologous corneal stem cell transplantation or pterygium excision with biological treatment of amniotic membrane transplantation is an ideal surgery, the recurrent rate is low especially in pterygium excision with autologous corneal stem cell transplantation.


Jiang Y.-M.,Suining Center Hospital | Wan J.-Y.,Suining Center Hospital | Gong X.,Suining Center Hospital | Liu Y.-J.,Suining Center Hospital | And 2 more authors.
Chinese Journal of Biologicals | Year: 2011

Objective: To observe the protective effect of hesperidin on acute hepatic failure (AHF) caused by lipopolysaccharide (LPS) combined with D-galactosamine (D-GalN) in mice and investigate the relevant mechanism. Methods: Mouse model of AHF was copied by injection i.p. with LPS (50 μg/kg) and D-GalN (800 mg/kg), and treated by hesperidin (200 mg/kg) or hesperidin (200 mg/kg) combined with zinc protoporphyrin XI(ZnPP, 45 mg/kg). The degrees of hepatic injury and inflammatory reaction were determined 6 h, while the death rate of mice 48 h after the model was copied. Results: Hesperidin decreased the serum transaminase, relieved the hepatic injury and increased the survival rate of mice with AHF. Compared with those without treatment, the IL-10 level in sera as well as the heme oxygenase-1 (HO-1) expression level and activity in liver of mice with AHF treated by hesperidin increased significantly, while tumor necrosis factor-α (TNF-α) level in sera as well as caspase-3 and myeloperoxidase (MPO) activities in liver tissues decreased significantly. ZnPP showed no influence on the promoting effect of hesperidin on HO-1 expression in liver, however, it down-regulated the protective effect of hesperidin against inflammation and hepatic injury significantly by inhibiting HO-1 activity. Conclusion: Hesperidin increased the HO-1 activity by inducing HO-1 expresssion, thereby relieved inflammatory reaction and hepatic injury and protected mice against LPS/D-GalN-induced AHF.


Wang B.,Zhejiang University | Wu B.,Huazhong University of Science and Technology | Liu J.,Suining Center Hospital | Yao W.,Huazhong University of Science and Technology | And 5 more authors.
PLoS ONE | Year: 2014

Background: Calcium oxalate monohydrate (COM) is the major crystalline component in kidney stones and its adhesion to renal tubular cells leads to tubular injury. However, COM-induced toxic effects in renal tubular cells remain ambiguous. MicroRNAs (miRNAs) play an important role in gene regulation at the posttranscriptional levels. Objective: The present study aimed to assess the potential changes in microRNAs of proximal renal tubular cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals. Methodology: Lactate dehydrogenase (LDH) activity and DAPI staining were used to measure the toxic effects of HK-2 cells exposed to COM crystals. MicroRNA microarray and mRNA microarray were applied to evaluate the expression of HK-2 cells exposed to COM crystals. Quantitative real-time PCR (qRT-PCR) technology was used to validate the microarray results. Target prediction, Gene Ontology (GO) analysis and pathway analysis were applied to predict the potential roles of microRNAs in biological processes. Principal Findings: Our study showed that COM crystals significantly altered the global expression profile of miRNAs in vitro. After 24 h treatment with a dose (1 mmol/L), 25 miRNAs were differentially expressed with a more than 1.5-fold change, of these miRNAs, 16 were up-regulated and 9 were down-regulated. A majority of these differentially expressed miRNAs were associated with cell death, mitochondrion and metabolic process. Target prediction and GO analysis suggested that these differentially expressed miRNAs potentially targeted many genes which were related to apoptosis, regulation of metabolic process, intracellular signaling cascade, insulin signaling pathway and type 2 diabetes. Conclusion: Our study provides new insights into the role of miRNAs in the pathogenesis associated with nephrolithiasis. © 2014 Wang et al.


PubMed | Huazhong University of Science and Technology, Suining Center Hospital and Zhejiang University
Type: Journal Article | Journal: PloS one | Year: 2014

Calcium oxalate monohydrate (COM) is the major crystalline component in kidney stones and its adhesion to renal tubular cells leads to tubular injury. However, COM-induced toxic effects in renal tubular cells remain ambiguous. MicroRNAs (miRNAs) play an important role in gene regulation at the posttranscriptional levels.The present study aimed to assess the potential changes in microRNAs of proximal renal tubular cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals.Lactate dehydrogenase (LDH) activity and DAPI staining were used to measure the toxic effects of HK-2 cells exposed to COM crystals. MicroRNA microarray and mRNA microarray were applied to evaluate the expression of HK-2 cells exposed to COM crystals. Quantitative real-time PCR (qRT-PCR) technology was used to validate the microarray results. Target prediction, Gene Ontology (GO) analysis and pathway analysis were applied to predict the potential roles of microRNAs in biological processes.Our study showed that COM crystals significantly altered the global expression profile of miRNAs in vitro. After 24 h treatment with a dose (1 mmol/L), 25 miRNAs were differentially expressed with a more than 1.5-fold change, of these miRNAs, 16 were up-regulated and 9 were down-regulated. A majority of these differentially expressed miRNAs were associated with cell death, mitochondrion and metabolic process. Target prediction and GO analysis suggested that these differentially expressed miRNAs potentially targeted many genes which were related to apoptosis, regulation of metabolic process, intracellular signaling cascade, insulin signaling pathway and type 2 diabetes.Our study provides new insights into the role of miRNAs in the pathogenesis associated with nephrolithiasis.

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