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Li J.-G.,Affiliated Hospital of Zunyi Medical College | Hu X.,Affiliated Hospital of Zunyi Medical College | Zheng X.-B.,Affiliated Hospital of Zunyi Medical College | Li Y.-J.,Affiliated Hospital of Zunyi Medical College | And 2 more authors.
World Chinese Journal of Digestology | Year: 2015

AIM: To assess the efficacy and safety of totally extraperitoneal prosthetic (TEP) vs Lichtentein tension-free repair of inguinal hernia in adults. METHODS: China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), Wanfang Database, VIP Database, Foreign Medical Journal Full-Text Service (FMJS), PubMed and Cochrane Library were searched for randomized controlled trials (RCTs) comparing the efficacy of TEP vs Lichtentein tension-free repair of inguinal hernia in adults. RevMan 5.1 software was used for meta-analysis. RESULTS: We included 12 prospective randomized controlled trials with 3249 cases. Meta-analysis showed that: (1) operation time: results from 10 studies (n = 2642) showed a significant difference between the TEP group and Lichtenstein group (MD = 6.23, 95%CI: 2.07-10.38, P = 0.003); (2) postoperative complications: results from 10 studies (n = 2740) showed a significant difference between the two groups (OR = 0.56, 95%CI: 0.46-0.69, P < 0.0001); (3) hospital stay: results from 6 studies (n = 348) showed no significant difference between the two groups (MD = -0.84, 95%CI: -1.81-0.13, P = 0.09); (4) time to resumption of normal physical activity: results from 7 studies (n = 2329) showed a significant difference between the two groups (MD = -4.27, 95%CI: -5.58--2.96, P < 0.0001). CONCLUSION: Compared with the Lichtenstein group, the TEP group is associated with significantly reduced postoperative complication and time to resumption of normal physical activity. However, operation time in the Lichtenstein group is significantly lower than that in the TEP group. Larger and high quality studies are needed to verify our findings. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source


Zou B.,University of Sichuan | Li T.,Sichuan Provincial Cancer Hospital | Zhou Q.,Suining Center Hospital | Ma D.,North Sichuan Medical College | And 14 more authors.
Medicine (United States) | Year: 2016

To evaluate the treatment pattern and survival of patients receiving radical resection for primary small cell carcinoma of the esophagus (PSCCE). This retrospective study included 150 patients who received radical resection of PSCCE. Data were retrieved from 4 centers in Western China. Thirty-nine of 150 patients received postoperative chemo-radiotherapy, 62 received postoperative chemotherapy, and 49 received radical resection only. The median radiation dosage was 50 Gy. The chemotherapeutic regimen was platinum-based and lasted for 2 to 6 cycles (median, 3). Median disease-free survival (mDFS) and overall survival (mOS) were 12.0 and 18.3 months, respectively. Subgroup analysis revealed that postoperative therapy did not improve survival in limited stage I (LSI) disease, whereas postoperative chemotherapy improved survival in limited stage II (LSII) disease. Relative to chemotherapy alone, chemoradiotherapy did not improve survival in patients with completely resected LSII disease. A multivariate analysis indicated an association of no postoperative chemotherapy with shorter DFS (P = 0.050) and OS (P = 0.010). Higher lymph node stage and length of disease longer than 3 cm were poor prognostic factors for both DFS and OS. Adjuvant chemotherapy improves survival in PSCCE patients with completely resected LSII disease. Adjuvant treatment with postoperative chemotherapy alone or postoperative chemo-radiotherapy does not increase survival in completely resected LSI disease. © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved. Source


Zhou Q.,University of Sichuan | Zhou Q.,Suining Center Hospital | Zou B.-W.,University of Sichuan | Xu Y.,University of Sichuan | And 8 more authors.
Tumor Biology | Year: 2015

Polymorphisms in DNA repair genes impact on the synthesis of DNA repair proteins that are crucial to the repair of DNA damages induced by chemotherapy and radiotherapy. We retrospectively examined whether there was an association between the selected six single nucleotide polymorphisms (SNPs) of five DNA repair genes (PARP1-Val762Ala, XRCC1-Arg194Trp, XRCC1-Arg399Gln, XPC-Lys939Gln, BRCA1-Lys1183Arg, and BRCA2-Asn372His) and the clinical outcome of patients with primary small cell carcinoma of esophagus (SCCE), and it showed that the median progression-free survival (PFS) and the overall survival (OS) were 11.8 versus 9.7 months (P = 0.041) and 17.4 versus 14.8 months (P = 0.032) for patients carrying the variant allele (T/C + C/C) and the wild-type allele (T/T) of PARP1-Val762Ala polymorphism, respectively. However, no statistical significance was observed in the other five polymorphic loci (P > 0.05). When these six SNPs were combined, however, patients with at least three variant genotypes had significantly longer PFS and OS compared with those carrying less than three variant genotypes (P = 0.009 and P = 0.007, respectively). The presence of at least three polymorphic variants in certain DNA repair genes may impact on patient survival and could be a potential genomic predictor of clinical response to DNA-damaging treatment in SCCE patients. © 2014, The Author(s). Source


Wang B.,Zhejiang University | Wu B.,Huazhong University of Science and Technology | Liu J.,Suining Center Hospital | Yao W.,Huazhong University of Science and Technology | And 5 more authors.
PLoS ONE | Year: 2014

Background: Calcium oxalate monohydrate (COM) is the major crystalline component in kidney stones and its adhesion to renal tubular cells leads to tubular injury. However, COM-induced toxic effects in renal tubular cells remain ambiguous. MicroRNAs (miRNAs) play an important role in gene regulation at the posttranscriptional levels. Objective: The present study aimed to assess the potential changes in microRNAs of proximal renal tubular cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals. Methodology: Lactate dehydrogenase (LDH) activity and DAPI staining were used to measure the toxic effects of HK-2 cells exposed to COM crystals. MicroRNA microarray and mRNA microarray were applied to evaluate the expression of HK-2 cells exposed to COM crystals. Quantitative real-time PCR (qRT-PCR) technology was used to validate the microarray results. Target prediction, Gene Ontology (GO) analysis and pathway analysis were applied to predict the potential roles of microRNAs in biological processes. Principal Findings: Our study showed that COM crystals significantly altered the global expression profile of miRNAs in vitro. After 24 h treatment with a dose (1 mmol/L), 25 miRNAs were differentially expressed with a more than 1.5-fold change, of these miRNAs, 16 were up-regulated and 9 were down-regulated. A majority of these differentially expressed miRNAs were associated with cell death, mitochondrion and metabolic process. Target prediction and GO analysis suggested that these differentially expressed miRNAs potentially targeted many genes which were related to apoptosis, regulation of metabolic process, intracellular signaling cascade, insulin signaling pathway and type 2 diabetes. Conclusion: Our study provides new insights into the role of miRNAs in the pathogenesis associated with nephrolithiasis. © 2014 Wang et al. Source


Li X.-X.,Suining Center Hospital | Li Y.-J.,Suining Center Hospital | Liu Y.-H.,Affiliated Hospital of Zunyi Medical College | Liu X.-Y.,Suining Center Hospital
World Chinese Journal of Digestology | Year: 2015

AIM: To assess the impact of reduced preoperative fasting time on safety and efficacy in elective surgical patients. METHODS: Randomized controlled trials (RCTs) of preoperative fasting time in elective surgical patients were searched and retrieved through databases including CNKI, WanFang Data, China Biology Medicine disc (CBM), Foreign Medical Journal Full-Text Service (FMJS), Cochrane Library and PubMed. RevMan 5.1 software was used for Metaanalysis. RESULTS: Seven RCTs involving 1623 patients were included. Meta-analysis showed thatless preoperative hunger (RR = 0.35, 95%CI: 0.23-0.54, P < 0.00001), thirst (RR = 0.25, 95%CI: 0.15-0.40, P < 0.00001), and anxiety (RR = 0.26, 95%CI: 0.09-0.69, P = 0.007) were reported by those who had a shorter fast; however, it could not reduce the incidence of nausea (RR = 0.92, 95%CI: 0.73-1.16, P = 0.49) and vomiting (RR = 0.81, 95%CI: 0.58-1.13, P = 0.23) after the operation. CONCLUSION: Compared with traditional preoperative fasting, implementation of reduced preoperative fasting can reduce preoperative hunger, thirst and anxiety, but has no significant impact on the incidence of postoperative nausea and vomiting. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source

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