Suganthi Devadason Marine Research Institute

Tamil Nadu, India

Suganthi Devadason Marine Research Institute

Tamil Nadu, India
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Santhana Ramasamy M.,Tamil University | Arumugam P.,Tamil University | Manikandan S.,Madurai Kamaraj University | Murugan A.,Suganthi Devadason Marine Research Institute
American Journal of Drug Discovery and Development | Year: 2011

Marine gastropod molluscs known as cone snails produce a complex array of over 50,000 peptides evolved for defense and prey capture. These venom peptides of predatory snails represent a rich combinatorial Hke library of evolutionary selected, neuro pharmacologically active. A major portion of the venom components are small, disulphide rich peptides that potently and specifically target and modulate components of the neuromuscular system, particularly ligand gated, voltage gated ion channels and transporters, making them a valuable source of new ligands for studying the role of these targets play in normal and disease physiology. Conotoxins are genetically encoded a propeptides which following expression and cleaved by specialized endoprotease to produce the mature venom peptide. A vast number of conuspeptides reduce neuropathic pain in animal models. Though several peptide drugs are in preclinical and clinical development for the treatment of severe pain often associated with diseases such as cancer, less than 1% of cono peptides are pharmacologically explored. This review focuses on the fundamental aspects and families of conotoxins in addition to some of the novel conopeptides acting at different types of Voltage gated and ligand gated ion channels which may lead to molecular and therapeutic targets. © 2011 Academic Journals Inc.


Sasikala R.,Suganthi Devadason Marine Research Institute | Ravindran V.S.,Suganthi Devadason Marine Research Institute
Journal of Chemical and Pharmaceutical Research | Year: 2013

The Scorpion fish, Scorpaenopsis venosa collected from Kanyakumari coast, Tamil Nadu, West Coast of India was identified based on the morphological characters. The antibacterial assay with crude extracts and purified fractions of venom gland and gonad extract was carried out with six bacterial strains viz., Pseudomonas sp. Staphylococcus aureus, Vibrio harveyi, V. parahaemolyticus, Proteaus sp., and Escherichia coli. Antagonistic activity was noted against most of the bacterial species. The crude and fractions of gland and gonad, was potent against V. harveyi. The antifungal assay was carried out with three fungal strains viz., Rhizoctonia solani, Pythium proliferum and Aspergillus niger. Venom gland fractions inhibited the growth of Rhizoctonia solani. Other two fungi were resistant to venom gland and gonads crude extracts and fractions. The FTIR analysis of both the samples showed various peak values aligned as halide, amine, ether and alcohol.


Saritha K.,Suganthi Devadason Marine Research Institute | Mani A.E.,Suganthi Devadason Marine Research Institute | Priyalaxmi M.,Suganthi Devadason Marine Research Institute | Patterson J.,Suganthi Devadason Marine Research Institute
Global Journal of Pharmacology | Year: 2013

The antibacterial activity of seaweed extracts of 9 different solvents were checked against 11 human pathogens and 5 fish pathogens. The acetone extract of Ulva lactuca showed broad spectrum of antibacterial activity when compared to other solvent extracts. The Ulva lactuca had high content of protein (20.8%) followed by 13.27% carbohydrates and 4.4%. of lipid content. © IDOSI Publications, 2013.


Renitta R.E.,Karunya University | Patterson J.,Suganthi Devadason Marine Research Institute
Journal of Food Processing and Preservation | Year: 2013

In India, oysters, clams, mussels and a few gastropods are local delicacies along the coastal region. Of these total catch, few marine gastropods are not utilized by the people because of lack of awareness about the rich nutritive value of the seafood products. Keeping this in mind, an attempt was made to study the shelf life of the pickled product developed from gastropods such as Chicoreus ramosus and Hemifusus pugilinus for a period of 8 and 6 months at ambient temperature (30±2C). The acceptability of gastropod pickles decreased as free fatty acid, trimethylamine nitrogen, total volatile base nitrogen, total plate count and sensory scores increased (P<0.01 and P<0.05) at the end of storage period. It is ready-to-eat product, and it can be stored for a period of 8 and 6 months for C.ramosus and H.pugilinus pickle, respectively. PRACTICAL APPLICATIONS: Fish pickling has been one of the most popular traditional preservation methods in India. Fishes are mainly preserved by using tamarind, spices, salt and acetic acid as pickling agents. These seafood pickles are safe without any harmful bacteria and have a long shelf-life period for more than 6 months at ambient temperature. However, gastropods are not familiar seafood and are consumed only by certain section of fishing population in India. They are fished mainly for their beautiful shells and operculum. The shells are used as ornaments and also used in lime industry. The operculum is used in Indian traditional medicine. For better utilization of these underutilized marine gastropods, pickled products were developed from Chicoreus ramosus and Hemifusus pugilinus. This present study would reveal the quality of pickled products and concluded that it can be stored for a period of 8 and 6 months. © 2012 Wiley Periodicals, Inc.


Guleria S.,Campus Management | Edward J.K.P.,Suganthi Devadason Marine Research Institute
Journal of Coastal Conservation | Year: 2012

India has a long coastline of about 7,517 km. with 20% occupying the coastal area. Due to increase in population; people have been exploring the possibility of developmental opportunities in the coastal areas. Tsunami in 2004 was another unexpected natural catastrophe which badly affected many South Indian coastal states especially the state of Tamil Nadu. Coastal communities here are increasingly at risk from many chronic and episodic coastal hazards which threaten the health and stability of coastal ecosystems and communities. The degradation of the coastal environment from chronic human-induced actions threaten food security, livelihoods, the overall economic development and well being of coastal communities. Disasters big or small affecting the coastal communities are reminders that, coastal communities are not resilient to normally recurring hazards. This fact has raised the question of developing community resilience since the most effective approach to reducing the long-term impact of coastal hazards would be to enhance capacities of coastal communities through initiatives which are aimed at ensuring a sustainable recovery in the aftermath of a disaster as well as reducing people's vulnerability to these disasters. Eight elements of resilience i. e., Governance, Coastal Resource Management, Land Use and Structural Design, Society and Economy, Risk Knowledge, Warning and Evacuation, Emergency Response and Disaster Recovery have been identified which are considered essential to reduce risk from coastal hazards, accelerate recovery from disaster events, and adapt to changing conditions by the affected community. In this paper, all the eight resilience elements have been examined with respect to vulnerability and capacity assessment in selected Tsunami (2004) affected districts in the state of Tamil Nadu, India in order to identify the extent of resilience. © 2011 Springer Science+Business Media B.V.


Gnanambal K.M.E.,Sri Ramachandra University | Patterson J.,Suganthi Devadason Marine Research Institute | Patterson E.J.K.,Suganthi Devadason Marine Research Institute
Phytotherapy Research | Year: 2015

A total of 40 extract types of varying polarities from commonly occurring seagrasses were tested for their antibacterial efficiency against 14 clinically isolated human pathogens using agar well diffusion technique. The extracts from acetone of Cymodocea serrulata expressed moderate broad span of activity against a range of gram-positive and gram-negative isolates that were at least resistant to five of the commercially available antibiotics at a minimal concentration of 10μg. The active extracts of C. serrulata that showed maximal inhibitions were purified using column chromatography that afforded six compounds (a-f). Compound f elicited pronounced inhibitions against Escherichia coli with minimal inhibitory concentration values of 1-3μg concentration using micro-dilution method. The active compound was identified as phenyl thioketone using various spectral analyses. This is the first investigation that reveals thioketone functionality from this seagrass species possessing antibacterial actions. This study indicates that there are thiocarbonyl groups from marine floral sources too, which could be possibly used for therapeutic purposes. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.


Emmanuel Joshua Jebasingh S.,Suganthi Devadason Marine Research Institute | Murugan A.,Suganthi Devadason Marine Research Institute
World Journal of Medical Sciences | Year: 2011

Bacterial strains associated with the barnacle Balanus amphitrite, distributed along Tuticorin coast, were studied for antagonistic activity against 10 human pathogenic bacterial strains. In cross streaking antibacterial assay involving the strains as such, antagonistic activity was observed in 14.3% of the 28 isolated associated bacteria. Out of four strains which showed antagonistic activity, the strain B3 showed higher antagonistic activity against 90% of bacterial pathogens. The subsequent culture of four active strains and screening of supernatant diethyl ether, chloroform, ethyl acetate and butanol extracts showed wide spectrum activity in ethyl acetate extract of B3 strain. The partitioning and column fractionation of supernatant ethyl acetate extract of B3 strain indicated wide spectrum antibacterial activity indicating the non-polar nature of the active substance. The strain B3 produced exocelluar metabolites, which though may have an ecological role to play with in nature, may provide a vital lead to antibacterials to combat human bacterial pathogens. © IDOSI Publications, 2011.


Thinesh T.,Suganthi Devadason Marine Research Institute | Mathews G.,Suganthi Devadason Marine Research Institute | Patterson Edward J.K.,Suganthi Devadason Marine Research Institute
Indian Journal of Marine Sciences | Year: 2011

Present study consists the details related to the nature of coral disease in nine locations from Vethalai to Rameswaram north in the Palk Bay. Among the overall corals 21% were affected by disease. Six disease types were documented. Black Band Disease (BBD) is high with 9.8% followed by white band (5.5%), white spot (2.2%), pink spot (1.9%), white plague (1.1%) and yellow band (0.6%). Eight coral genera were found to be affected wherein Acropora and Porites showed severe damage and the high prevalence of diseases. The coral genus, Porites was found to be affected by four different types of diseases. BBD affected colonies were tagged and photographed at regular intervals to quantify the progression rate in two coral genera, Acropora and Platygyra and the disease progression rate was 3 cm per month. White band disease was widespread and was found to affect exclusively Acropora sp. Corals like Symphylia sp. and Cyphastrea sp. in the Palk Bay were comparatively not affected by diseases. Total heterotrophic bacteria and pathogenic microbial forms in the reef environment were also examined in the present study.


Raj K.D.,Suganthi Devadason Marine Research Institute | Edward J.K.P.,Suganthi Devadason Marine Research Institute
Indian Journal of Marine Sciences | Year: 2010

Pattern of reproduction was studied in Acropora species along Tuticorin coast in the Gulf of Mannar from 2006-2008. Extensive surveys were conducted to monitor reproductive maturity and the timing of spawning. Gametes were observed from January with colonies releasing gametes by the end of March. Acropora cytherea showed immature colonies in January (48-79%) and February (56-76%) and mature colonies in March (36-86%). Likewise, the other species of Acropora examined showed 50-75% of immature colonies in January and an increase of 10-20% of immature colonies in February, and matured in March. The average percentage of mature colonies in March was as follows, A. formosa 47-76%, A. valenciennesi 50-81%, A. intermedia 50-81%, A. nobilis 25-82%, A. micropthalma 56-83%, A. hemprichi 39-83%, A. hyacinthus 33-100%, A. corymbosa 59-65%. Spawning was observed in A. cytherea on 24 March 2006, 10 days after full moon; 28 March in 2007, 5 days prior to full moon; and 8 March 2008, 1 day after new moon. Approximately 30,000 egg and sperm bundles were observed in 1 litre of water and each bundle had 20-25 eggs in A. cytherea. Environmental parameters, especially rise in temperature at the end of March was believed to play lead role in coral spawning.


Mariya V.,Suganthi Devadason Marine Research Institute | Ravindran V.S.,Suganthi Devadason Marine Research Institute
Indian Journal of Marine Sciences | Year: 2013

Seaweeds are a group of non-flowering marine plants commonly referred to as marine macroalgae. Taxonomically, they are classified into Rhodophyta (red algae), Phaeophyta (brown algae) and Chlorophyta (green algae) depending on their pigments and/or chemical composition1. Seaweeds contain various inorganic and organic substances which can benefit mankind. Various compounds with biological activities have been isolated2,3 and they possess pharmacological activities such as Antibiotic, Anticoagulant, Antioxidant, Antiproliferative, Antitumoral, Anticomplementary, Antiinflammatory, Antibacterial, Antifungal, Antiviral, Antihelminthic, Antiprotozoan, Antipeptic, Hypolipidemic, Antiadhesive and Antifouling activities4-13. The present paper reviews the biomedical and pharmacological properties of seaweeds.

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