The Suez Canal University is an Egyptian university serving the Suez Canal area, having its faculties divided among the Suez Canal governorates . It was established in 1976. It is notable for its non-classic research. It has 28 faculties with a total number of students reaching 21,325.The University has about 53 special units for research, education and community development. Wikipedia.
Khafagy E.-S.,Suez Canal University |
Morishita M.,Hoshi University
Advanced Drug Delivery Reviews | Year: 2012
During the past few decades, the novel biotherapeutic agents such as peptides and proteins have been contributed to the treatment of several diseases. However, their oral absorption is significantly limited due to their poor delivery through the intestinal mucosa. Therefore, the feasible approaches are needed for improving the oral bioavailability of biodrugs. Recently, cell-penetrating peptides (CPPs) such as HIV-1 Tat, penetratin and oligoarginine are considered as a useful tool for the intracellular delivery of therapeutic macromolecules. Hence, it was expected that the ability of CPPs may be applicable to enhance the absorption of biodrugs through intestinal epithelial membrane. CPPs are likely to become powerful tools for overcoming the low permeability of therapeutic peptides and proteins through the intestinal membrane, the major barrier to their oral delivery. Further advantage of this promising strategy is that this successful intestinal absorption could be achieved by more convenient methodology, coadministration of CPP with drugs via intermolecular interaction among them. Hereafter, the further establishment of delivery system based on CPPs is required to realize the development of the oral forms of therapeutic peptides and proteins. The aim here is to introduce our vision focusing on oral biodrug delivery by the use of CPPs as potential peptide carrier in order to provide new information in the design and development of new oral delivery systems for novel biotherapeutics. © 2012 Elsevier B.V.
El-Sagheer A.H.,University of Southampton |
El-Sagheer A.H.,Suez Canal University |
Brown T.,University of Southampton
Accounts of Chemical Research | Year: 2012
Biochemical strategies that use a combination of synthetic oligonucleotides, thermostable DNA polymerases, and DNA ligases can produce large DNA constructs up to 1 megabase in length. Although these ambitious targets are feasible biochemically, comparable technologies for the chemical synthesis of long DNA strands lag far behind. The best available chemical approach is the solid-phase phosphoramidite method, which can be used to assemble DNA strands up to 150 bases in length. Beyond this point, deficiencies in the chemistry make it impossible to produce pure DNA. A possible alternative approach to the chemical synthesis of large DNA strands is to join together carefully purified synthetic oligonucleotides by chemical methods. Click ligation by the copper-catalyzed azide-alkyne (CuAAC) reaction could facilitate this process. In this Account, we describe the synthesis, characterization, and applications of oligonucleotides prepared by click ligation.The alkyne and azide oligonucleotide strands can be prepared by standard protocols, and the ligation reaction is compatible with a wide range of chemical modifications to DNA and RNA. We have employed click ligation to synthesize DNA constructs up to 300 bases in length and much longer sequences are feasible. When the resulting triazole linkage is placed in a PCR template, various DNA polymerases correctly copy the entire base sequence. We have also successfully demonstrated both in vitro transcription and rolling circle amplification through the modified linkage. This linkage has shown in vivo biocompatibility: an antibiotic resistance gene containing triazole linkages functions in E. coli. Using click ligation, we have synthesized hairpin ribozymes up to 100 nucleotides in length and a hammerhead ribozyme with the triazole linkage located at the substrate cleavage site. At the opposite end of the length scale, click-ligated, cyclic mini-DNA duplexes have been used as models to study base pairing. Cyclic duplexes have potential therapeutic applications. They have extremely high thermodynamic stability, have increased resistance to enzymatic degradation, and have been investigated as decoys for regulatory proteins. For potential nanotechnology applications, we have synthesized double stranded DNA catenanes by click ligation. Other researchers have studied covalently fixed multistranded DNA constructs including triplexes and quadruplexes. © 2012 American Chemical Society.
El-Sagheer A.H.,University of Southampton |
El-Sagheer A.H.,Suez Canal University |
Brown T.,University of Southampton
Chemical Society Reviews | Year: 2010
The advent of click chemistry has led to an influx of new ideas in the nucleic acids field. The copper catalysed alkyne-azide cycloaddition (CuAAC) reaction is the method of choice for DNA click chemistry due to its remarkable efficiency. It has been used to label oligonucleotides with fluorescent dyes, sugars, peptides and other reporter groups, to cyclise DNA, to synthesise DNA catenanes, to join oligonucleotides to PNA, and to produce analogues of DNA with modified nucleobases and backbones. In this critical review we describe some of the pioneering work that has been carried out in this area (78 references). © 2010 The Royal Society of Chemistry.
Ahmed A.S.,Suez Canal University
Renewable and Sustainable Energy Reviews | Year: 2010
Analysis of the wind characteristics in Ras Benas city located on the east coast of Red Sea in Egypt using measured data (wind, pressure and temperature) and Weibull function were made. Statistical analysis model to evaluate the wind energy potential was introduced. According to the power calculations done for the site, the annual mean wind density is 315 kW/m 2 at a height of 70 m above ground level. This station has a huge wind energy potential for electricity generation, especially during spring and summer seasons, comparing with some European countries. In addition, the monthly wind turbine efficiency parameter (η monthly) has been calculated by using a commercial wind turbine 1 MW with 70 m hub height to help designers and users in evaluating the potentialities and choosing the suitable wind turbine for the considered site. The use of wind turbine with capacity greater than 1000 kW at this station was recommended. Ras Benas station was selected to install 30 MW-wind farm consists of 20 commercial wind turbines (Nordex S 77) with hub heights and Rotor diameter were 100 and 77 m, respectively. This site has annual wind speed more than 9.8 m/s at 100 m height and enough area to locate these turbines. The estimated energy production using WASP Program of these wind farm was 130 GWh/year. Furthermore, the production costs was found 1.3 cent/kWh, which is a competition price at the wind energy world market. © 2010 Elsevier Ltd.
El-Bialy M.Z.,Suez Canal University
Gondwana Research | Year: 2010
The Pan-African Kid-Malhak Dokhan volcanic suite (609 ± 12 Ma) is exposed in the northernmost part of the Arabian-Nubian Shield. The suite consists of non-metamorphosed varicolored alternating succession of porphyritic lava flows of commonly felsic composition (rhyolite-dacite) interlayered with compositionally equivalent pyroclastic beds (dominantly ignimbrites). These Dokhan volcanics are quite evolved (SiO2 ≈ 65-77 wt.%), with strong high-K calc-alkaline affinity and are characterized by relative enrichment in total alkalis, Ba, Y, Zr and total REEs, depletion in Sr, and a LREE-enriched REE patterns with significant negative Eu anomalies. The Kid-Malhak Dokhan lavas display geochemical characteristics of both orogenic arc-type and anorogenic within-plate environments, suggesting eruption in a transitional "post-collisional tectonic setting. The ages of emplacement of the Dokhan volcanics in Egypt including that of Kid-Malhak region (580-620 Ma) coincide with end of the documented collision between the juvenile Arabian-Nubian crust and Saharan Metacraton and the subsequent extensional collapse event. This post-collision transition from compression to extension is explained by the extensional collapse following continental collision, which was controlled mainly by lithospheric delamination and slab breakoff (passive rifting). Various trace element characteristics discussed herein have indicated that the studied Dokhan magma was highly likely generated from crustal sources and that assimilation-fractional crystallization (AFC) and crustal contamination have played a major role and are most probably superimposed on fractional crystallization during the magmatic evolution of Kid-Malhak Dokhan volcanic suite. The eruption of the high-K calc-alkaline post-collisional Dokhan volcanics in Egypt defines a tectono-magmatic transition between the older calc-alkaline arc-related and the subsequent alkaline magmatism in the northern part of the Arabian-Nubian Shield. © 2009.
Tawfik M.K.,Suez Canal University
International Immunopharmacology | Year: 2015
Methotrexate (MTX) is a cornerstone disease modifying anti-rheumatic drug. One of its major drawbacks is hepatotoxicity, resulting in poor compliance of therapy. Coenzyme Q10 (CoQ10) is an antioxidant and anti-inflammatory compound, possessing both anti-arthritic and hepatoprotective potential. The present study was carried out to evaluate the effect of CoQ10 (10 mg/kg) alone and in combination with MTX (2 mg/kg) on the progression of adjuvant-induced arthritis in rats, and to elucidate the potential properties of CoQ10 in ameliorating MTX-induced liver damage in rats. Rats were assigned to; normal, arthritic, MTX treated, CoQ10 treated or a combination of MTX and CoQ10. CoQ10 administration potentiated the antiarthritic effect of MTX. Moreover, the combination therapy was effective in attenuating the severity of MTX-induced liver damage displayed by the improvement in hepatospecific serum markers and confirmed by the histo-pathological evaluation. Additionally, it attenuated the hepatic oxidative stress and the intensity of inflammatory mediators associated with MTX administration as evident by the regulation of oxidant/anti-oxidant balance and the inhibitory effects on TNF-α and IL-6 levels. These results revealed that CoQ10 can serve as a useful adjuvant and promote the safe use of MTX in the management of arthritis, not only by potentiating the antiarthritic effect of MTX, but also by alleviating MTX-induced hepatocellular injury. © 2014 Elsevier B.V.
Mabrouk A.N.A.,Suez Canal University
Desalination | Year: 2013
This work presents a technoeconomic comparison between once through long tube (MSF-OT-LT) with atmospheric deaerator, and brine recycle cross tube (MSF-BR-CT) evaporators. The process design and cost analysis of 30 MIGD MSF-OT-LT evaporator is presented.The process calculations showed that for the same performance ratio, the heat transfer area of MSF-OT-LT is 34% lower than that of MSF-BR evaporator. This is due to the flashing range increase and higher heat transfer coefficient of MSF-OT-LT configuration. The pumping power of the MSF-OT-LT is 40% lower than that of MSF-BR-CT evaporator. This is due to lower friction loss in the tubes and due to remove brine recycle pump. A novel configuration of MSF-OT-LT is proposed in which the stages are arranged in a triple deck. The footprint decreases up to 57% in the large size project of 150 MIGD.For a large size project of 150 MIGD capacity, the unit water cost of the MSF-OT-LT configuration is 36% lower than that of the MSF-BR-CT. It can be concluded from this study that the MSF-OT-LT evaporator is a viable option for large scale capacity and a reliable technology for poor quality and high salinity sea water. © 2013 Elsevier B.V.
Fahmy M.A.,Suez Canal University
Numerical Heat Transfer; Part A: Applications | Year: 2013
A numerical model based on the dual reciprocity boundary element method (DRBEM) is extended to study the generalized magneto-thermo-viscoelastic problem in a rotating solid of functionally graded material (FGM) in the context of the Green and Naghdi theory of type III. The material properties of the solid have a gradient in the thickness direction and are anisotropic in the plane of the solid. An implicit-implicit staggered strategy was developed and implemented for use with the DRBEM to obtain a solution for the displacement and temperature fields. The accuracy of the proposed method was examined and confirmed by comparing the obtained results with those known previously. In the case of three-dimensional, a numerical scheme for the implementation of the method is presented and the numerical computations are presented graphically to show the effect of the energy dissipation on the temperature and displacement components. © 2013 Copyright Taylor and Francis Group, LLC.
Hussein B.H.M.,Suez Canal University
Journal of Luminescence | Year: 2011
The absorption and fluorescence spectra of 7, 8-dihydroxy-4-methylcoumarin (DHMC) in ethanolwater (1:9 v/v) solution at varying pH values were investigated . The interaction between DHMC and bovine serum albumin (BSA) was investigated by fluorescence, FT-IR, and circular dichroism (CD) spectroscopy. The SternVolmer quenching constant (KSV), the quenching rate constant of the bimolecular reaction (Kq), the binding constant, and number of binding sites (n) of DHMC with BSA were evaluated. The results showed that DHMC quenches the fluorescence intensity of BSA through a static quenching process. Positive value of entropy change (ΔS) and negative value of enthalpy change (ΔH) of the BSADHMC interaction were obtained according to the vant Hoff equation. The interaction between DHMC and BSA was driven mainly by hydrophobic forces. The binding process was spontaneous and exothermic. The binding distance between the tryptophan residue in BSA and the DHMC was found to be about 2.6 nm based on the Frster theory of non-radiation energy transfer. © 2010 Elsevier B.V. All rights reserved.
Fahmy M.A.,Suez Canal University
Engineering Analysis with Boundary Elements | Year: 2012
The main objective of this paper is to study the transient magneto-thermo-visco-elastic stresses in a non-homogeneous anisotropic solid placed in a constant primary magnetic field acting in the direction of the z-axis and rotating about it with a constant angular velocity. The system of fundamental equations is solved by means of a dual-reciprocity boundary element method (DRBEM). In the case of plane deformation, a numerical scheme for the implementation of the method is presented and the numerical computations are carried out for the temperature, displacement components and thermal stress components. The validity of DRBEM is examined by considering a magneto-thermo-visco-elastic solid occupies a rectangular region and good agreement is obtained with the results obtained by other methods. The results obtained are presented graphically to show the effect of inhomogeneity on the displacement components and thermal stress components. © 2011 Elsevier Ltd. All rights reserved.