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Deshmukh V.N.,Sudhakarrao Naik Institute of Pharmacy
International Journal of PharmTech Research | Year: 2012

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Methods to improve patient's compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. MDDDS have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Therefore, these dosage forms have lured the market for a certain section of the patient population which include dysphagic, bed ridden, psychic, geriatric and paediatric patients. Research in developing orally disintegrating systems has been aimed at investigating excipients as well as technique to meet these challenges. Technologies used for manufacturing of orally disintegrating tablets are either conventional technologies or patented technologies. In conventional freeze drying, tablet molding, sublimation, spray drying etc. and in patented Zydis technology, Orasolv technology, Durasolv technology, Wowtab technology, Flashdose technology are important. Important ingredients that are used in the formulation of ODTs should allow quick release of the drug, resulting in faster dissolution. Source

Nitalikar M.M.,Suresh Gyan Vihar University | Sakarkar D.M.,Sudhakarrao Naik Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2013

Skin delivery of NSAIDs offers several advantages over the oral route associated with potential side effects. The present research has been undertaken with the aim to develop a topical gel formulation of Meloxicam, which would attenuate the gastrointestinal relater toxicities associated with oral administration. Meloxicam is a nonsteroidal antiinflammatory drug. It has antiinflammatory, analgesic and antipyretic activity through inhibition of prostaglandinsynthetase, via inhibition of cyclooxygenase enzymes. This study was designed to enhance the solubility of Meloxicam by preparing its inclusion complex with -cyclodextrin and formulating gels using Carbopol 940 and HPMC E 6. The gels were evaluated for release through goat abdominal skin. It was observed that the formulation containing complex (DCG 2) was good in all respects. © RJPT All right reserved. Source

Sarage R.D.,Sudhakarrao Naik Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2012

The purpose of this research work was to develop a stable formulation of Antihypertensive drugs of the Telmisartan and Hydrochlorothiazide immediate release bilayer tablet and to study the dissolution profile with the reference product. The Formulation development work was initiated with wet granulation (drug layering technique) as the APIs are very static in nature and having very poor flow property. In order to improve solubility and drug release, Telmisartan is converted to its sodium salt by dissolving in aqueous solution of Sodium Hydroxide. Lactose Monohydrate and Microcrystalline Cellulose are used as diluents. Sodium Starch Glycolate is added as a superdisintegrant and Magnesium Stearate is used as the lubricant. The prepared granules are compressed into Double layer compression machine. The tablets thus formulated showed satisfactory physical parameters, and it was found to be stable and in-vitro release studies are shown that formulation (A5B5) shows Cumulative percent drug release 98.9-103.7% within 60min and matches with that of Innovator. Source

Chauhan H.V.,Sudhakarrao Naik Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2011

Present in-vivo study was carried out to evaluate the antidiabetic, lipid lowering and antioxidant activity of methanolic extract of Lawsonia inermis leaves in alloxan induced diabetic rats using glibenclamide (10mg/kg) as standard drug. Oral administration of methanolic extract of Lawsonia inermis leaves (600mg/kg body weight) for 14 days resulted in significant decrease in fasting blood glucose level (34.33%), serum triglycerides (43.35%), total cholesterol (34.18%), low density lipoprotein (11.05%), GOT (42.89%), and GPT (28.09%) with simultaneous increase in serum high density lipoprotein (50.48%) and serum glucokinase (208.75%). Further the methanolic extract of Lawsonia inermis leaves inhibited the generation of Malondialdehyd (TBARS) level (34.34%) in alloxan induced diabetic rats. The results of the present study demonstrate antidiabetic, lipid lowering and antioxidant activities in methanolic extract of Lawsonia inermis leaves, which could help in prevention of diabetic hyperlipedemia and related diseases. © RJPT All right reserved. Source

Tembhurne S.V.,Sudhakarrao Naik Institute of Pharmacy | Sakarkar D.M.,Sudhakarrao Naik Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

Alzheimer's disease (AD) is said to be the leading cause of dementia in elderly individuals exhibit a marked decline in cognitive functions. There are several factors involves in the pathogenesis of AD e.g. involvement of cholinesterase enzyme, oxidative free radicals and high cholesterol level promoting risk for and exacerbating AD pathology. In the light of this, the present study was undertaken to investigate the influence of petroleum ether extracts (300 and 500mg/kg p.o.) of Murraya koenigii leaves (MKL) on memory in aged mice. The study was also undertaken to evaluate for cholinesterase and cholesterol level. The result of the present study indicates that administration of MKL for 15 days produce significant dose dependant improvement of memory. The results also indicate to reduce the brain cholinesterase activity and total cholesterol levels respectively. Thus it concludes that the underlying mechanism of action for the observed nootropic effect may be attributed to anticholinesterase and a cholesterol lowering property of MKL. Therefore, it would be worthwhile to investigate specifically the therapeutic potential of MKL in the management of Alzheimer patients. Source

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