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Meerut, India

Kumar S.,Subharti University
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH | Year: 2013

It is known that the computer users develop the features of dry eye. To study the cytological changes in the conjunctiva using conjunctival impression cytology in computer users and a control group. Fifteen eyes of computer users who had used computers for more than one year and ten eyes of an age-and-sex matched control group (those who had not used computers) were studied by conjunctival impression cytology. Conjunctival impression cytology (CIC) results in the control group were of stage 0 and stage I while the computer user group showed CIC results between stages II to stage IV. Among the computer users, the majority ( > 90 %) showed stage III and stage IV changes. We found that those who used computers daily for long hours developed more CIC changes than those who worked at the computer for a shorter daily duration. © NEPjOPH.


Jayant S.,Bharat Institute of Technology | Sharma B.M.,Bharat Institute of Technology | Bansal R.,Subharti University | Sharma B.,Amity University | Sharma B.,Conscience Research
Pharmacology Biochemistry and Behavior | Year: 2016

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that pervasively affects the population across the world. Currently, there is no effective treatment available for this and existing drugs merely slow the progression of cognitive function decline. Thus, massive effort is required to find an intended therapeutic target to overcome this condition. The present study has been framed to investigate the ameliorative role of selective modulator of cannabinoid receptor type 2 (CB2), 1-phenylisatin in experimental AD condition. We have induced experimental AD in mice by using two induction models viz., intracerebroventricular (i.c.v.) administration of streptozotocin (STZ) and aluminum trichloride (AlCl3) + d-galactose. Morris water maze (MWM) and attentional set shifting test (ASST) were used to assess learning and memory. Hematoxylin-eosin and Congo red staining were used to examine the structural variation in brain. Brain oxidative stress (thiobarbituric acid reactive substance and glutathione), nitric oxide levels (nitrites/nitrates), acetyl cholinesterase activity, myeloperoxidase and calcium levels were also estimated. i.c.v. STZ as well as AlCl3 + d-galactose have impaired spatial and reversal learning with executive functioning, increased brain oxidative and nitrosative stress, cholinergic activity, inflammation and calcium levels. Furthermore, these agents have also enhanced the burden of Aβ plaque in the brain. Treatment with 1-phenylisatin and donepezil attenuated i.c.v. STZ as well as AlCl3 + d-galactose induced impairment of learning-memory, brain biochemistry and brain damage. Hence, this study concludes that CB2 receptor modulation can be a potential therapeutic target for the management of AD. © 2015 Elsevier Inc.


Verma A.,Sam Higginbottom Institute of Agriculture | Prateek P.,Sam Higginbottom Institute of Agriculture | Prateek P.,Subharti University | Thakur A.,Sam Higginbottom Institute of Agriculture | And 3 more authors.
International Journal of ChemTech Research | Year: 2016

(Formula presented) A series of novel 4-aminoquinoline 1, 3, 5-triazine derivatives were synthesized via Six step reactions. All synthesized compounds were characterized by FT-IR, 1HNMR, 13CNMR And Mass spectrometry. The antibacterial activity of 10 synthesized compounds were tested against three gram positive bacteria Bacillus subtilis (NCIM-2063), Bacillus cereus (NCIM-2156), Staphylococcus aureus (NCIM-2079) and four gram negative bacteria Proteus vulgaris (NCIM-2027), Proteus mirabilis (NCIM-2241), Escherichia coli (NCIM-2065), Pseudomonas aeruginosa (NCIM-2036) by using ciprofloxacin as reference standard drug. Compound 11i and 11j were found most potent among synthesized derivatives, against all bacterial strains. © 2016, Sphinx Knowledge House. All rights reserved.


Singh S.,CMS Government Girls Polytechnic Daurala | Singh S.,Subharti University | Agrawal S.,The New School
Energy Conversion and Management | Year: 2016

The work has been carried out in two steps; firstly the parameters of hybrid dual channel semitransparent photovoltaic thermal module has been optimized using a fuzzyfied genetic algorithm. During the course of optimization, overall exergy efficiency is considered as an objective function and different design parameters of the proposed module have been optimized. Fuzzy controller is used to improve the performance of genetic algorithms and the approach is called as a fuzzyfied genetic algorithm. In the second step, the performance of the module has been analyzed for four cities of India such as Srinagar, Bangalore, Jodhpur and New Delhi. The performance of the module has been evaluated for daytime 08:00 AM to 05:00 PM and annually from January to December. It is to be noted that, an average improvement occurs in electrical efficiency of the optimized module, simultaneously there is also a reduction in solar cell temperature as compared to un-optimized module. © 2016 Elsevier Ltd. All rights reserved.


Singh S.,CMS Government Girls Polytechnic Daurala | Singh S.,Subharti University | Agrawal S.,The New School | Tiwari A.,BAG Energy Research Society | And 2 more authors.
Solar Energy | Year: 2015

The PV research community and industry has major focus on the new advancement and improvement on power efficiency of PV systems. An attempt has been made to model and optimize the parameter of hybrid single channel photovoltaic thermal (PVT) module. In this paper it has been observed that there are many parameters that affect the electrical efficiency of a hybrid single channel PVT module like thickness of the glass and tedlar, temperature of the inlet flow, and solar cell temperature. All equations for solar cell and thermal collector have been derived. By using genetic algorithms (GAs), thermal efficiency and electrical efficiency of the system may be optimized. All the parameters that are used in genetic algorithms are the parameters that could be changed, and the non changeable parameters, like solar radiation cannot be used in the algorithm. It has been observed that the GAs are very efficient technique to estimate the design parameters of hybrid single channel PVT module. © 2015 Elsevier Ltd.

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