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Meerut, India

Chhabra R.,Subharti Dental College
Annals of Tropical Medicine and Public Health | Year: 2016

Dental caries is one of the most common irreversible diseases of the tooth structure where a wide group of microorganisms are responsible as they are the main etiologic bacteria. To reduce the incidence and prevalence of dental caries, various modalities have been adopted over the years by modifying various etiologic factors. One of the latest advances is caries vaccine that involves the application of advanced genetic technique by modifying Streptococcus mutans (S. mutans) and using it as a dental vaccine. This review article highlights the mechanism and prospects for dental caries vaccine that in the times ahead will be a blessing for health care providers. © 2016 Annals of Tropical Medicine and Public Health | Published by Wolters Kluwer - Medknow. Source

Nagaraju K.,Subharti Dental College | Prasad S.,Bapuji Dental College | Ashok L.,Bapuji Dental College
Indian Journal of Dental Research | Year: 2010

Background and Objectives: In vivo stains are prompt resources, which have emerged, in the recent years, to aid as clinical diagnostic tools in detecting early premalignant and malignant lesions. The aim of the study was to determine the diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignancies and malignancies and to evaluate the reliability of in vivo staining with toluidine blue and Lugol's iodine in the lesions at risk of malignancy. Materials and Methods: The study group comprised 30 subjects with clinically suspicious premalignant lesions and 30 subjects with clinically suspicious malignant lesions. All the lesions were stained consecutively with toluidine blue and Lugol's iodine and the dye retention were recorded with photographs. Depending on the retention of the dyes, the biopsy site was determined. The biopsy specimens were sent for histological confirmation and results were statistically analyzed. Results: The overall diagnostic accuracy of Lugol's iodine when used consecutively with toluidine blue stain in distinguishing premalignant lesions and malignant lesions was 90%. As the degree of differentiation of malignant lesions progressed toward more severity, they failed to show the retention of Lugol's iodine and the result was highly significant statistically, with a P value < 0.001. Interpretation and Conclusion: Lugol's iodine when used with toluidine blue helped in delineating the inflammatory lesions and was the mean source in determining clinically the degrees of differentiation of malignant lesions as the poorly differentiated malignant lesions without glycogen content failed to show Lugol's iodine retention. Toluidine blue with Lugol's iodine can be used as a pretherapeutic assessment of the biologic aggressiveness of the disease. Source

Aggarwal P.,Subharti Dental College | Saxena S.,Subharti Dental College
Indian Journal of Cancer | Year: 2011

Objectives: The present study was undertaken to detect and compare the pattern of collagen fibers in odontogenic cysts and also to find out if this methodology could be used to predict the aggressive nature of odontogenic cysts by comparing with the odontogenic tumors. Materials and Methods: The collagen in the wall of 11 odontogenic keratocysts, 14 dentigerous cysts and 14 radicular cysts was studied histochemically by staining sections with picrosirius red and examining under polarizing microscope. This was compared to 10 cases of odontogenic tumors using Z test of proportion at 1% and 5%. Results: In dentigerous cysts, odontogenic keratocysts and odontogenic tumors, the predominant color of collagen fibers birefringence was found to be orangish red, whereas in radicular cysts the collagen fiber was of green color. Conclusions: Similar birefringence pattern of collagen fibers between dentigerous cysts, odontogenic keratocysts and odontogenic tumors may indicate that these lesions have a common histogenesis with a broad spectrum of biological behavior and belong to the same group, i.e., are developmental in origin. Different patterns of radicular cysts suggest different biological behavior and a positive role of inflammation on polarization color of collagen fibers. Source

Aggarwal P.,Subharti Dental College | Saxena S.,Subharti Dental College
British Journal of Oral and Maxillofacial Surgery | Year: 2011

Epidermoid carcinoma and mucoepidermoid carcinoma that arise centrally within the jaws are often associated with dental cysts. Central mucoepidermoid carcinoma of the jaws is rare, and usually presents in the fourth to eighth decades; we know of only 7 cases that have been described in children younger than 16. Here we describe a central mucoepidermoid carcinoma in an 8-year-old girl that arose from a dentigerous cyst associated with an unerupted mandibular molar. © 2010 British Association of Oral and Maxillofacial Surgeons. Source

Chandna P.,Subharti Dental College | Adlakha V.K.,Subharti Dental College
Indian Pediatrics | Year: 2010

Dental caries in the primary dentition can have significant damaging effects on a child's growth due to impairment of oral functions. Since the first encounter of a child to a medical environment is often through pediatricians and medical practitioners, it is important that they be aware of the prevention of oral disease that begins early in life. The aim of this article is to diminish the existing ambiguity among pediatricians and medical practitioners regarding oral disease and its prevention. Source

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