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Xiong Q.-Q.,Central South University | Wang D.-R.,Subei Peoples Hospital of Jiangsu Province | Liang Y.,Yangzhou University
World Chinese Journal of Digestology | Year: 2016

The liver is the main target organ of metastasis for gastric cancer. Gastric cancer with liver metastases (GCLM) has a poor prognosis and is a challenge for treatment of patients with gastric cancer. At present the mechanism of liver metastases of gastric cancer is unclear, and there have been no unified treatment guidelines. This paper mainly discusses the molecular mechanism and comprehensive therapy of liver metastases of gastric cancer. © 2016 Baishideng Publishing Group Inc. All rights reserved. Source

Wang D.,Nanjing Medical University | Chen H.,Wuxi Peoples Hospital | Wang S.,Nanjing Medical University | Zou Y.,Wuxi Peoples Hospital | And 8 more authors.
Clinical Rheumatology | Year: 2016

Thalidomide is effective for treating severe cutaneous lupus patients. The aim of this study was to observe the optimum effective and maintenance doses of thalidomide to maximize clinical benefit and minimize side effects for patients with cutaneous lupus in China. Sixty-nine patients with lupus rash from eight hospitals in China were enrolled and treated with different doses of thalidomide. We started the dose of thalidomide at 25 mg daily and gradually increased administration dose once a week until erythema was markedly improved. The effective and maintenance doses were documented. The size of skin lesions was noted once a week. Systemic lupus erythematosus disease activity index (SLEDAI) score, levels of erythrocyte sedimentation rate (ESR), and serum TNF-α were measured before and after treatment. The remission rates were evaluated weekly until 8 weeks. Sixty-eight percent of patients showed an effective dose of 50 mg daily; another 13, 10, and 9 % of patients had an effective dose of 100, 75, and 25 mg daily, respectively. The maintenance dose was 50 mg daily for 71 % of the patients, and 100, 75, and 25 mg daily for 9, 14, and 6 % of the patients. SLEDAI score and serum ESR levels significantly decreased 4 weeks after thalidomide treatment. At the end of the fourth week, the rates of complete remission, partial remission, and no response were 56 % (n = 39), 41 % (n = 28), and 3 % (n = 2). At the eighth week, the rate of total remission rose up to 100 %. The most common side effects were drowsiness and constipation. No peripheral neuropathy was observed in these patients. Thalidomide at a dose of 50 mg daily may offer a better benefit to risk ratio in the treatment of Chinese cutaneous lupus patients. © 2016, International League of Associations for Rheumatology (ILAR). Source

Shu Y.-S.,Subei Peoples Hospital of Jiangsu Province | Tao W.,Subei Peoples Hospital of Jiangsu Province | Miao Q.-B.,Subei Peoples Hospital of Jiangsu Province | Lu S.-C.,Subei Peoples Hospital of Jiangsu Province | Zhu Y.-B.,Yangzhou East Hospital
Inflammation | Year: 2014

Galangin, an active ingredient of Alpinia galangal, has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung protection in lipopolysaccharide (LPS)-induced ALI. Male BALB/c mice were randomized to receive galangin or vehicle intraperitoneal injection 3 h after LPS challenge. Samples were harvested 24 h post LPS administration. Galangin administration decreased biochemical parameters of oxidative stress and inflammation, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of galangin were associated with inhibition of nuclear factor (NF)-κB and upregulation of heme oxygenase (HO)-1. Galangin reduces LPS-induced ALI by inhibition of inflammation and oxidative stress. © 2014, Springer Science+Business Media New York. Source

Ge Y.-L.,Subei Peoples Hospital of Jiangsu Province | Li X.,Subei Peoples Hospital of Jiangsu Province | Gao J.,Subei Peoples Hospital of Jiangsu Province | Zhang X.,Subei Peoples Hospital of Jiangsu Province | And 4 more authors.
Experimental and Therapeutic Medicine | Year: 2016

The present study aimed to investigate the effects of dexmedetomidine (DEX) on cognition following a carotid endarterectomy (CEA). In addition, the neuroprotective effects of DEX against ischemia-reperfusion injury during CEA were analyzed. Patients due to undergo elective CEA under general anesthesia were randomly assigned to either the DEX-treated group (group D; n=25) or the control group (group C; n=25). Patients in group D were treated with 0.3 μg/kg DEX pre-CEA, followed by 0.3 μg/kg/h DEX intraoperatively up to 30 min prior to the completion of surgery, and the patients in group C received an equal volume of normal saline. Cognitive function was assessed prior to CEA (T0), and at 24, 48, and 72 h, 7 days and 1 month post-surgery (T1-5, respectively), using the Mini-Mental State Examination (MMSE). Blood samples were drawn from the ipsilateral jugular bulb of all patients at 20 min prior to anesthesia (t0), and at 10 min following tracheal intubation, 15 min following clamping and unclamping of the carotid artery, and at 6 and 24 h postoperatively (t1-5, respectively). The protein expression levels of markers of cerebral ischemia and injury, namely S100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE), and the concentration of the oxidative stress marker malondialdehyde (MDA), were analyzed. Patients in group D exhibited elevated MMSE scores at T2 and T3 post-CEA, as compared with group C. Furthermore, the protein expression level of S100B and the concentration of MDA in the jugular bulb of group D patients were markedly decreased compared with those in group C at t3-5 and t3, respectively. The results of the present study suggested that DEX was able to enhance the recovery of cognition following CEA, and this was associated with decreased cerebral damage and antioxidative effects. © 2016, Spandidos Publications. All Rights reserved. Source

Chen L.,Subei Peoples Hospital of Jiangsu Province | Zhao W.,Subei Peoples Hospital of Jiangsu Province | Wang L.,Subei Peoples Hospital of Jiangsu Province | Gao S.-J.,Subei Peoples Hospital of Jiangsu Province | And 4 more authors.
World Chinese Journal of Digestology | Year: 2015

AIM: To evalute the efficacy and safety of peroral endoscopic myotomy (POEM) for esophageal achalasia (AC), submucosal tunnel endoscopic resection (STER) for esophageal submucosal tumors (SMT) originating from muscularis propria layer and endoscopic submucosal tunnel dissection (ESTD) for large esophageal superficial neoplasms. METHODS: A retrospective study was performed of the clinical data of 10 patients with esophageal achalasia treated by POEM, 18 patients with esophageal submucosal tumors originating from muscularis propria layer treated by STER, and 22 patients with large esophageal superficial neoplasms treated by ESTD at Department of Gastroenterology, Subei People’s Hospital of Jiangsu Province from September 2012 to January 2015. Intraoperative and postoperative complications and clinical efficacy were recorded.RESULTS: The surgeries were successful in all patients. Subcutaneous emphysema occurred in three patients treated by POEM and eight patients by STER, and mediastinal emphysema occurred in one patient treated by POEM. In the 10 cases of POEM,the mean submucosal tunnel length was 10.1 cm ± 2.7 cm, the average length of endoscopic myotomy was 8.4 cm ± 1.9 cm, and the mean operation time was 72.5 min ± 29.1 min. Dysphagia symptom was improved significantly during 6 mo of the followup. In the 18 cases of STER, the average lesion size was 1.5 cm ± 0.6 cm, the average operation time was 52.3 min ± 21.4 min, and postoperative pathological examination revealed that all were leiomyomas. Postoperative follow-up duration ranged from 3 to 6 mo and no residual lesion or recurrence was found. In the 22 cases of ESTD, the length of lesions ranged from 2.5 cm to 6.0 cm and the width from 1/3 to 4/5 of the esophageal circumference. The average operation time was 82.9 min ± 26.5 min. Postoperative pathology was suggestive of 16 cases of high-grade intraepithelial neoplasia and 6 cases of intramucosal carcinoma. During 6 mo of follow-up there was no recurrence. Four patients had postoperative esophageal strictures and were alleviated by pneumatic balloon dilatation and retrievable esophageal stent implantation. CONCLUSION: Submucosal tunnel endoscopy is a safe and effective method for rectal esophageal achalasia, esophageal submucosal tumors originating from the muscularis propria layer and large esophageal superficial neoplasms. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source

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