Subbaiah Institute of Medical science

Shimoga, India

Subbaiah Institute of Medical science

Shimoga, India

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Raghavendra R.,Subbaiah Institute of Medical science | Bheemappa H.,Bangalore Medical College and Research Institute | Devadass P.K.,Bangalore Medical College and Research Institute
Medico-Legal Update | Year: 2016

Introduction: Abdominal trauma usually occurs due to Road accidents, fall from height, Results of a homicidal act-by kicking or by fisting, during sports and only extremely rarely it is the lap seat belt. The structures most likely to be damaged in blunt abdominal trauma in order of frequency are: liver, spleen, kidney, intestines, abdominal wall, mesentery, pancreas and diaphragm. Objective: 1. To study the prevalence liver injuries in relation to various factors viz., epidemiological factors, socio-economic status, penetrating/ non-penetrating injuries, time of occurrence etc. 2. To identify the risk, so as to facilitate the early diagnosis of trauma by the clinicians. 3. To study the relationship between severity of the injuries and survival period Materials and method: Materials for the present study were collected from the medico legal autopsies, showing abdominal injuries, carried out at the mortuary of Victoria hospital and Bowring and Lady Curzon hospitals, attached to Bangalore medical college & research institute, Bengaluru during the period from 1st November 2012 to 31st October 2014 for a period of 24 month. The total numbers of cases studied were 100. All the autopsies showing abdominal trauma were included in the study Results: Out of the 100 cases of studied, the commonest age group of the victims was 30-39 years (32%) followed by the age group of 20-29 yrs (29%). 44 cases were brought dead. Men were more involved than women with a ratio of 9: 1. Conclusion: The initial management of liver trauma generally follows the same procedures for all traumas with a focus on maintaining airway, breathing, and circulation. A physical examination is a corner stone of the assessment of which there are various non-invasive means of diagnostic tools that can be utilized. © 2016, World Informations Syndicate. All rights reserved.


Havanur B.,Bangalore Medical College and Research Institute | Raghavendra R.,Subbaiah Institute of Medical science | Pradeep Kumar M.P.,Bangalore Medical College and Research Institute
Medico-Legal Update | Year: 2016

Most of the undergraduates in medical schools are unaware of the importance of medico legal autopsy. Once the student are admitted to second year the student, many a times are in a dilemma why autopsies are to be witnessed by them at that point of time and are ignorant of the legal procedure which imbibes the medical professional to conduct autopsy in many cases of un-natural deaths where the cause of death is not known. Once the medical undergraduate gets the awareness regarding the Medico legal autopsy or forensic autopsy he has a different approach towards it. One such study was conducted at Bengaluru involving 200 students of 5th term on voluntary basis, who had ample knowledge regarding medico legal autopsy. A set of questionnaires were given to them and results tabulated and was concluded. This study shows the emotional reaction of the students and it indicates that the necropsy is of value in medical education. © 2016, World Informations Syndicate. All rights reserved.


Kadi S.,Subbaiah Institute of Medical science | Manjunath S.,International Medical School
Biomedicine (India) | Year: 2012

Background & Objectives: To determine oxidative stress by estimating blood malondialdehyde (MDA) levels and to assess the non-enzymatic antioxidant status by measuring plasma vitamin A, vitamin E and vitamin C levels in Rheumatoid arthritis (RA) patients and then comparing with the healthy individuals. Methods: Forty (40) subjects served as controls and 40 RA patients served as cases. The controls and cases were from both sexes and age group of 40-60 years. The parameters were estimated by standard biochemical methods. Results: The mean level of blood MDA (in nmol/ml) in controls was 6.19 ± 0.96 and 11.48 ± 0.76 in cases. The blood levels of MDA in RA cases were significantly increased as compared to controls (p<0.0001). The mean values of vitamin A, vitamin E and vitamin C in controls were 35.13+5.25 μg/dl, 0.92+0.10 mg/dl and 0.88+0.12 mg/dl respectively. The mean values of vitamin A, vitamin E and vitamin C in cases were 11.60 + 3.03 μg/dl, 0.53 + 0.14 mg/dl and 0.48 + 0.09 mg/dl respectively. A highly significant decrease in plasma levels of vitamin A, vitamin E and vitamin C was observed in RA cases as compared to controls(p<0.0001). Interpretation & Conclusion: The study concludes that there is an increased oxidative stress and a decreased antioxidant defense in patients with rheumatoid arthritis as evidenced by increased lipid peroxidation and low antioxidant levels.


Rao P.,Subbaiah Institute of Medical science | Chethan H.A.,Subbaiah Institute of Medical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

To Study the effect of isometric leg press exercise test on Intra ocular pressure in young adults. Healthy young male adults in the age group of 18-22 years were selected among MBBS phase I students of a Medical college .Sample size was 40. Heart rate and IOP were recorded at rest and after isometric leg press test. Right eye IOP has decreased significantly from resting 16.28±1.55 to 9.30±1.79(p < 0.001)immediately after leg press exercise IOP Left eye IOP has decreased significantly from resting 16.15±1.69 to 13.04±1.19 (p < 0.001) immediately after handgrip exercise IOP. Isometric leg press exercise lowers IOP which were significant. Hence may prove useful in normotensive glaucomatous patients.


Pyati A.K.,Belagavi Institute of Medical science | Halappa C.K.,Subbaiah Institute of Medical science | Pyati S.A.,Navodaya Dental College | Nagaraj,Raichur Institute of Medical science | Wali V.,M R Medical College
Journal of Clinical and Diagnostic Research | Year: 2015

Background: The diagnostic accuracy of currently available standard panel of liver function tests is not satisfactory for the reliable diagnosis of chronic liver disorders. Earlier studies have reported that serum basal paraoxonase 1 (PON1) activity measurement may add a significant contribution to the liver function tests. Aim: To assess whether the measurement of serum basal paraoxonase 1 (PON1) activity would be useful as an index of liver function status in chronic hepatitis patients. Materials and Methods: The study included 50 chronic hepatitis patients and 50 apparently healthy controls based on inclusion & exclusion criteria. In all the subjects, standard liver function tests were analysed by using standard methods. Basal PON1 activity was estimated using spectrophotometric method by the hydrolysis of p-nitrophenylacetate. Student t-test, Pearson’s correlation coefficient, diagnostic validity tests and ROC curve analysis were the methods used for the statistical analysis of the data. Results: The serum basal PON1 activity was significantly decreased in chronic hepatitis cases when compared to controls (p< 0.001). Also basal PON1 activity was positively correlated with serum total protein and albumin, and negatively correlated with serum total bilirubin, alanine amino transferase (ALT), and alkaline phosphatase (ALP) (p< 0.001) in chronic hepatitis cases but not in healthy controls. Diagnostic validity tests showed, basal PON1 activity was a better discriminator of chronic hepatitis than total protein, albumin and ALP with sensitivity of 68%, specificity of 100%, positive predictive value of 100% and negative predictive value of 75%. ROC curve analysis demonstrated highest diagnostic accuracy for ALT (AUC = 0.999) followed by PON1 (AUC = 0.990), total bilirubin (AUC = 0.977), ALP (AUC = 0.904), total protein (AUC = 0.790) and albumin (AUC = 0.595). Conclusion: Diagnostic accuracy of serum PON1 activity is better than total bilirubin, total protein, albumin and ALP. PON1 activity measurement could significantly improve the current efficiency of a laboratory’s evaluation of patients with suspected chronic hepatitis. © 2015 Journal of Clinical and Diagnostic Research All rights reserved.


Sambu N.K.,RIMS | Kashinath R.T.,Subbaiah Institute of Medical science | Ambekar J.G.,Hospital and Research Center
Journal of Clinical and Diagnostic Research | Year: 2015

Background: Diabetes Mellitus is a chronic metabolic disorder which may lead to various complications, the important being dyslipidemia leading to Coronary Heart Disorders (CHD), the major cause for morbidity and mortality in diabetic patients. Diabetes Mellitus could be treated by nutritional therapy/drug therapy and others. But the drug therapy would have its own limitations and side effects. To overcome from this an herbal extract is recommended, such as Diallyl Disulphide (DADS) a principle compound of Garlic oil. Aim: To assess the hypolipidemic effect of Diallyl Disulphide (DADS) in alloxan induced diabetic rats. Materials and Methods: Healthy adult wistar strain male albino rats weighing around 100-150 grams were randomly selected from the animal house at BLDE University’s Shri B.M.Patil Medical College, Hospital and Research Centre, Bijapur, India. Diabetes was induced using alloxan and was treated with DADS. After a stipulated time the rats were anesthetised and sacrificed to collect the blood and liver tissue. Various Lipid parameters, HMG CoA Reductase, Fecal bile acids were estimated in the blood, feces and homogenised liver tissue using standard procedures. Statiscal Analysis: One-way ANOVA followed by post-hoc t-test is done. Result: There was significant decrease in the blood and liver tissue lipid parameters of DADS treated alloxan induced diabetic rats when compared to the alloxan induced diabetic rats. Conclusion: From this study it can be concluded that the DADS a principle compound of garlic, definitely has the hypolipidemic effect in diabetic rats, which is reducing the morbidity in diabetic cases due to dyslipidemia without the adverse effects. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Channabasappa S.,SSS Mansion | Dharmappa S.,Subbaiah Institute of Dental science | Pandurangi R.,Subbaiah Institute of Medical science
Saudi Journal of Anaesthesia | Year: 2016

A 48-year-old male patient with a long-standing history of ankylosing spondylitis (AS) presented for ureteroscopic stone removal. On preoperative assessment, tracheal intubation was likely to be difficult due to decreased cervical spine mobility. Traditional neuraxial block was impossible due to the fusion of vertebral bodies. AS patients present the most serious array of intubation, which is secondary to decrease in cervical spine mobility and possible temporomandibular joint disease. Management of a case of AS can be very challenging when the airway and the central neuraxial blockade, both are difficult. Fluoroscopic assisted central neuraxial blockade may lead to predictable success in AS. We present a case report with severe AS where conventional techniques failed and C-arm assisted helped in successful epidural anesthesia for ureteroscopic stone removal. © 2016 Saudi Journal of Anesthesia.


Bhaktha G.,Subbaiah Institute of Medical Science | Shivananda Nayak B.,Subbaiah Institute of Medical Science | Shivananda Nayak B.,University of the West Indies | Mayya S.,Manipal University India | Shantaram M.,Mangalore University
Journal of Clinical and Diagnostic Research | Year: 2015

Introduction: Coffee though not usually thought of as healthy food but can be treated as one of the beneficial drink. Many researchers have found strong evidence that coffee reduces the risk of several serious ailments, including diabetes, heart disease, cirrhosis of the liver, etc. The long term beneficial effect of coffee on diabetes is now understood to be more influential and obliging. Materials and Methods: This study comprised 220 healthy subjects of which 143 consumed coffee and 77 did not. These were matched with 90 diabetic subjects. Among the 90 diabetics, 48 consumed coffee and 42 did not consume coffee. Results: The mean adiponectin value was significantly higher in coffee consumed normal and diabetic subjects than the subjects who did not consume coffee. The decrease in fasting blood sugar and HbA1c values were also observed in normal and diabetic subjects who consumed coffee than the other groups who did not consume coffee. Significant difference (p<0.05) in mean FBG, PPBS, HbA1c and adiponectin were observed between coffee consumed and no coffee consumed groups. Conclusion: The long term use of caffeine is more efficient on blood sugar and adiponectin levels, which needed in the prevention of complications in diabetic subjects. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Ganesh H.R.,NITTE University | Krishna Prasad M.S.,Subbaiah Institute of Medical science | Vimal Kumar K.,NITTE University | Veena Shetty A.,NITTE University
Biomedicine (India) | Year: 2013

Introduction: Leptospirosis is a well known worldwide zoonotic disease caused by a spirochaete of the genus Leptospira. In India, leptospirosis is still an underreported disease in some regions, probably due to the lack of diagnostic facilities and also lack of awareness of the disease among physicians. In Karnataka, only few studies reported Leptospirosis and there is no extensive study of human leptospirosis in this coastal region of Karnataka. Aim: The study aims to see the seroprevalence of leptospirosis among patients visiting a tertiary hospital, presenting with acute fever including clinical manifestations of leptospirosis. Materials and Methods: A total of 121 serum samples were collected from patients with acute fever including those fulfilling the criteria of clinical diagnosis of leptospirosis. The study period was from August 2011 to July 2012. Inclusion criteria included more than three of the following symptoms - fever with headache, myalgia, jaundice, conjunctival suffusion and muscle tenderness or subconjunctival haemorrhage, chorioretinitis, oliguria, pulmonary haemorrhage, pedal edema and uveitis. All the sera were tested for Leptospiral IgM antibodies by two genus specific tests, Leptocheck-WB and Serion Verion ELISA. Blood culture, Widal test, HBsAg, anti HIV and anti HCV detection and antigen and antibody of Dengue virus were also conducted. Results: Out of 112, 18 (16%) were positive for Leptospira by both Leptocheck-WB and Serion Verion ELISA. All the convalescent sera were positive by these tests. The male-female ratio was 7:2. Out of the outstanding 94 sera, 5 was positive for malaria parasite, 4 for Salmonella and 2 cases each of Hepatitis B and Dengue respectively. Two cases recorded had co-infection with Plasmodium vivax infection. In this study, leptospirosis was more prevalent among daily wage workers (38.8%) followed by farmers (16.8%). Conclusion: Leptospirosis is a seasonal zoonotic disease which is not uncommon in patients visiting a tertiary hospital. As clinical symptoms simulate other diseases such as enteric fever, viral fever including dengue and hepatitis, it may be under diagnosed. As this study included a small sample size, larger epidemiological study should be carried out to know the actual prevalence. Patients presenting with fever of more than 3 days should be screened for Leptospirosis especially during and following monsoons.


PubMed | University of the West Indies, Subbaiah Institute of Medical Science, Mangalore University and Manipal University India
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

Coffee though not usually thought of as healthy food but can be treated as one of the beneficial drink. Many researchers have found strong evidence that coffee reduces the risk of several serious ailments, including diabetes, heart disease, cirrhosis of the liver, etc. The long term beneficial effect of coffee on diabetes is now understood to be more influential and obliging.This study comprised 220 healthy subjects of which 143 consumed coffee and 77 did not. These were matched with 90 diabetic subjects. Among the 90 diabetics, 48 consumed coffee and 42 did not consume coffee.The mean adiponectin value was significantly higher in coffee consumed normal and diabetic subjects than the subjects who did not consume coffee. The decrease in fasting blood sugar and HbA1c values were also observed in normal and diabetic subjects who consumed coffee than the other groups who did not consume coffee. Significant difference (p<0.05) in mean FBG, PPBS, HbA1c and adiponectin were observed between coffee consumed and no coffee consumed groups.The long term use of caffeine is more efficient on blood sugar and adiponectin levels, which needed in the prevention of complications in diabetic subjects.

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