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Vecera L.,Neurologicka Klinika | Bednarik J.,Neurologicka Klinika | Bednarik J.,Stredoevropsky Technologicky Institute CEITEC
Ceska a Slovenska Neurologie a Neurochirurgie | Year: 2012

Guillain-Barré syndrome (GBS) is an acute autoimmune polyradiculoneuropathy with a monophasic course, the development of which takes a maximum of four weeks. Relapse is rare (approximately 3% of cases). As opposed to chronic inflammatory demyelinating polyneuropathy (CIDP), where a link to lymphoma and certain other malignancies has been described, linkage of GBS to cancer is questionable. Nevertheless, several cases occur in the literature describing the occurrence of GBS in patients with malignancies. This case report covers a patient with renal carcinoma who presented with GBS, and possible linkage to malignancy is discussed. Source

Majerova V.,Neurologicka Klinika | Roth J.,Neurologicka Klinika | Waishaupt J.,Neurologicke Odd. | Bezdicek O.,Neurologicka Klinika | And 8 more authors.
Ceska a Slovenska Neurologie a Neurochirurgie | Year: 2011

Limbic encephalitis was initially described as a rare paraneoplastic syndrome characterized by rapid progression, anterograde amnesia, mood disturbances, psychiatric symptoms and temporal lobe epilepsy. In the last decade, the concept of limbic encephalitis has expanded - apart from any paraneoplastic aetiology, it may occur as an infectious or autoimmune disorder (that may or may not be associated with antineuronal antibodies). Due to its various non-specific symptoms, early diagnosis of limbic encephalitis is frequently difficult. The first reported case, a 53-year-old female, presented with short-term memory loss, and was treated initially for Alzheimer's disease, later developing typical symptoms of limbic encephalitis with rapid alteration of consciousness, accompanied by seizures and discrete temporal lobe signal change on MRI. The second case was a 38-year-old male with rapidly progressing amnesia and behavioural disturbances. Development of epileptic seizures, typical medial temporal lobe signal change on MRI and abnormal increase of antibodies against voltage-gated potassium channels confirmed a diagnosis of limbic encephalitis. Both cases improved after corticosteroid therapy. No paraneoplastic origin was found in either case. We discuss the most usual signs and symptoms of limbic encephalitis, focusing on recent classification, diagnostics and treatment of this often under-diagnosed disorder. Source

Reguli H.,Sexuologicke Oddeleni FN Brno | Sejbalova P.,Sexuologicke Oddeleni FN Brno | Zourkova A.,Sexuologicke Oddeleni FN Brno | Zourkova A.,Stredoevropsky Technologicky Institute CEITEC
Ceska a Slovenska Psychiatrie | Year: 2012

Aim of this study was to analyze 13 cases of sexually delinquent behavior in higher middle aged men. We focused on proportion of cognitive deficit and pedophile preference on paraphilic behavior. Material and methods: processing records, sexological examination, phaloplethysmography, assessment of plasma testosterone levels, carbohydrate deficient transferring test (CDT), and psychological examination with focus on cognitive function. Results: Some degree of cognitive deficit was found in 7 patients. PPG assessment showed pedophile preference in 7 patients and undifferentiated activity in 6 patients. Eight patients had regular sexual live. In 7 cases we have find comorbidity with metabolic syndrome, hypertension and diabetes. In paper we discussed about organic etiology of pedophile behavior and about probability of primary pedophilia in elderly. Conclusion: In patients with cognitive deficit, somatic comorbidity and undifferentiated PPG activity we can assume that pedophile behavior is related to organic brain damage. In Patients with pedophile preference findings on PPG it is likely to unmask the pedophilia. Source

S H.,Interni hematologicka a onkologicka klinika | Folber F.,Interni hematologicka a onkologicka klinika | Lek S.,Ustav hematologie a krevni transfuze | Horacek J.M.,IV. interni hematologicka klinika | And 4 more authors.
Transfuze a Hematologie Dnes | Year: 2015

Acute lymphoblastic leukaemia (ALL) is predominantly a childhood disease and its incidence in adults is low. The prognosis and treatment outcome in adults are less satisfactory than in children. However, many new discoveries have been made recently. This review describes diagnostic procedures and treatment options in adult ALL. It focuses on minimal residual disease and its prognostic significance; on several new genetic abnormalities, such as IKZF1 (Ikaros) and NOTCH1 gene mutations and on the new prognostic categories of Ph-like (BCR-ABL1-like) ALL and early T-cell precursor (ETP) ALL. An overview of new drugs currently being tested in clinical trials, especially monoclonal antibodies and antibody-drug conjugates, is also presented. Source

Zelinkova J.,Stredoevropsky Technologicky Institute CEITEC | Urbanek T.,Psychologicky Ustav Akademie Ved CR | Marecek R.,Stredoevropsky Technologicky Institute CEITEC | Brazdil M.,Stredoevropsky Technologicky Institute CEITEC
Ceska a Slovenska Neurologie a Neurochirurgie | Year: 2011

Motivational and decision-making processes are important tools in both making daily decisions and overall survival of the physical subject. In the last decade many studies have investigated how these processes function in the human brain. Functional magnetic resonance imaging (fMRI) has played a large part in research into the relationships between motivation and decision-making on the one hand and cerebral activity on the other. Current results suggest that certain areas of the brain are functionally associated with motivational and decision-making processes. This article provides an overview of the most significant recent studies into seeking to identify the structures of the human brain involved in motivational and decision-making processes. In the past, much attention was paid to "gain motivation" (for example, towards financial reward), but current science also focuses on moral motivation, the study of which is addressed in the following part of the article. Some diseases associated with motivational and decision-making disorders are shown in the last part of the article. Source

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