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Lewin J.J.,Johns Hopkins Hospital | Choi E.J.,Strategic Analysis Enterprises, Inc. | Ling G.,Darpa
American Journal of Health-System Pharmacy | Year: 2016

Purpose. Developmental pharmaceutical manufacturing systems and techniques designed to overcome the shortcomings of traditional batch processing methods are described. Summary. Conventional pharmaceutical manufacturing processes do not adequately address the needs of military and civilian patient populations and healthcare providers. Recent advances within the Defense Advanced Research Projects Agency (DARPA) Battlefield Medicine program suggest that miniaturized, flexible platforms for end-to-end manufacturing of pharmaceuticals are possible. Advances in continuous-flow synthesis, chemistry, biological engineering, and downstream processing, coupled with online analytics, automation, and enhanced process control measures, pave the way for disruptive innovation to improve the pharmaceutical supply chain and drug manufacturing base. These new technologies, along with current and ongoing advances in regulatory science, have the future potential to (1) permit "on demand" drug manufacturing on the battlefield and in other austere environments, (2) enhance the level of preparedness for chemical, biological, radiological, and nuclear threats, (3) enhance health authorities' ability to respond to natural disasters and other catastrophic events, (4) minimize shortages of drugs, (5) address gaps in the orphan drug market, (6) support and enable the continued drive toward precision medicine, and (7) enhance access to needed medications in underserved areas across the globe. Conclusion. Modular platforms under development by DARPA's Battlefield Medicine program may one day improve the safety, efficiency, and timeliness of drug manufacturing. Copyright © 2016, American Society of Health-System Pharmacists, Inc.


Colella W.,Strategic Analysis Enterprises, Inc.
EFC 2013 - Proceedings of the 5th European Fuel Cell Piero Lunghi Conference | Year: 2013

This research applies the Theory of Constraints to current and future global energy supply chains. Within conventional automotive supply chains, the greatest constraint to energy efficiency is typically at the point of vehicle use. Within a future transport supply chain based on hydrogen (H2)-fueled proton exchange membrane (PEM) fuel cell vehicles (FCVs), the energy efficiency constraint shifts to include not only the vehicle but also the process of producing H2 fuel. To address this constraint, this research analyzes an innovative approach for producing H2 fuel efficiently: tri-generative stationary high temperature (HT) fuel cell systems (FCSs) that simultaneously produce electricity, heat, and hydrogen fuel (H2-FCSs). This research discusses H2-FCS thermodynamics, chemical engineering process plant design, economics, and environmental impacts. Thermodynamic models indicate that H2-FCSs use ~19% less fuel to produce electricity, compared with standard stationary FCSs, and ~16% less fuel, compared with standalone steam methane reformers (SMRs). Copyright © 2013 Delta Energy and Environment.


Grant
Agency: Department of Defense | Branch: Air Force | Program: SBIR | Phase: Phase I | Award Amount: 148.62K | Year: 2012

ABSTRACT: For this project, we propose to modify our existing natural language processing (NLP) techniques to conduct automated discourse analysis on original documents produced by the People"s War Group (PWG) in India. Using templates developed by Toman et al (2010) we will evaluate our ability to automatically identify and measure shifts in in-group alliance building, out-group distancing, and the cognitive complexity of PWG senior leadership, as expressed in their writings in the group"s newsletter the People"s March. If successful, these techniques will facilitate the development of prototype software that will allow analysts to monitor, assess, and forecast, in near real time, the consequences of shifts in rhetoric employed by insurgent and extremist organizations. BENEFIT: Commercial applications will involve a data and analysis subscription service for clients in the defense, intelligence, and diplomatic domains, along with customized analysis and training.


Miranda R.A.,Infinimetrics Corporation | Casebeer W.D.,Darpa | Hein A.M.,Strategic Analysis Enterprises, Inc. | Judy J.W.,University of Florida | And 9 more authors.
Journal of Neuroscience Methods | Year: 2014

The Defense Advanced Research Projects Agency (DARPA) has funded innovative scientific research and technology developments in the field of brain-computer interfaces (BCI) since the 1970s. This review highlights some of DARPA's major advances in the field of BCI, particularly those made in recent years. Two broad categories of DARPA programs are presented with respect to the ultimate goals of supporting the nation's warfighters: (1) BCI efforts aimed at restoring neural and/or behavioral function, and (2) BCI efforts aimed at improving human training and performance. The programs discussed are synergistic and complementary to one another, and, moreover, promote interdisciplinary collaborations among researchers, engineers, and clinicians. Finally, this review includes a summary of some of the remaining challenges for the field of BCI, as well as the goals of new DARPA efforts in this domain. © 2014 The Authors.


Beaudoin M.E.,Strategic Analysis Enterprises, Inc. | Schmorrow D.D.,Office of the Secretary of Defense
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2011

This paper provides a summary of the presentations presented in the Operational Neuroscience session during Augmented Cognition International 2011 at Human Computer Interaction International 2011 in Orlando, Florida, July, 2011. © 2011 Springer-Verlag.

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