Stpeters Institute Of Pharmaceutical Science

Warangal, India

Stpeters Institute Of Pharmaceutical Science

Warangal, India
SEARCH FILTERS
Time filter
Source Type

Malladi M.,C J Pharma Research India Pvt Ltd | Jukanti R.,Stpeters Institute Of Pharmaceutical Science | Nair R.,DR. Reddys Laboratories Ltd | Wagh S.,DR. Reddys Laboratories Ltd | Padakanti H.,Stpeters Institute Of Pharmaceutical Science
Latin American Journal of Pharmacy | Year: 2010

The objective of present work was to assess ion exchange resins for taste masking of Dextromethorphan Hydrobromide (DM) - a highly bitter drug. A strong cationic exchange resin (Amberlite® IRP-69) and weak cationic exchange resin (Amberlite® IRP-64) were evaluated. Based on drug loading efficiency, Amberlite® IRP-69 was selected for further evaluation. The effect of different methods of drug loading, drug: resin ratios and particle size on drug complexation was evaluated. The formation of a resinate was confirmed based on Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transmission infra-red spectroscopy (FT-IR). The results from loading studies at different drug: resin ratios, 1:1, 2:1 and 3:1, indicated that, the drug loading achieved were 78%, 49% and 25% w/w, respectively. For a defined drug:resin ratio, resin particle size of 45-63μm showed highest drug loading whereas, resins with higher particle size, 125-150 μm showed the lower drug loading. The X-ray diffraction spectra showed absence of crystalline peaks indicating formation of resinates. DSC and XRPD showed that the molecular state of the entrapped drug in resinates changed from crystalline to amorphous state regardless of drug loading. The complexes were evaluated for bulk density, angle of repose, taste masking and in vitro drug release. In vitro drug release studies showed more than 80% drug r lease fromresinate prepared with Amberlite IRP 69 within 30 min. Based on the studies we can conclude that taste masking of Dextromethorphan Hydrobromide could be accomplished using a strong cationic ion exchange 0esin with a particle size 45-63 μm at a 1:1 Drug: Resin ratio.


Rani D.J.,Stpeters Institute Of Pharmaceutical Science | Priya B.V.,Stpeters Institute Of Pharmaceutical Science | Ramya V.,Stpeters Institute Of Pharmaceutical Science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

To identify the Drug Related Problems (DRPs) in patients with stroke treatment, to study the rate, types, pattern, and clinical significance of DRPs in stroke patients and to investigate the nature and frequency of DRPs along with pharmaceutical interventions to address them in patients with stroke from hospital admission to discharge. A prospective observational study was conducted in a super specialty hospital, Hanamkonda, Telangana, South India for 9 months from December 2014 to August 2015. The patients visiting inpatient department of Neurology were reviewed and patients diagnosed with ischemic and hemorrhagic stroke were enrolled into the study and DRPs in the patients were identified and assessed. 200 patients were enrolled in this study, out of which 117 patients were males and 83 patients were females. 141 patients were with ischemic stroke and 59 were with hemorrhagic stroke. A total of 375 DRPs were identified in 200 patients which included Drug Interactions 35.7%, Indication without drug 24.8%, Adverse Drug reactions 13.8%, Incorrect drug choice 8.2%, Unnecessary long duration 6.1%, Double medication 5.3%, Drugs without indication 3.2% and Contraindications 2.6%.Early detection and intervention of drug related problems may improve the therapeutic outcomes in stroke patients. Developing and adopting policies regarding the drug administration, dispensing and prescribing would minimize the drug related problems in stroke patients.


Jayaveera K.N.,Jawaharlal Nehru Technological University Anantapur | Sruthi K.,Stpeters Institute Of Pharmaceutical Science
Journal of Chemical and Pharmaceutical Sciences | Year: 2010

Journal of Chemical and Pharmaceutical Sciences Forty two New 2-{(benzalamino-4-hydroxybenzyl) (1,3,4)-oxadiazino[6,5-b]} Indole derivatives (V) have been synthesized by condensing 2-Amino-4-[(1,3,4)oxadiazino[6,5-b] indole-3-yl]-phenol (IV) with various aromatic aldehydes. The intermediates, on the other hand, have been synthesized by the cyclization of 3-Amino-4- hydroxybenzoic acid (2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (III) in presence of Concentrated H2SO4. The title compounds have been purified and characterized by their analytical and spectral data. They have screened for their antihistaminic activity and all the forty two compounds showed very good anti histaminic activity. Compounds V6 and V41 showed potent antihistaminic activity with IC50 values 3.25×10-5 mol/lit and 4.10×10-5 mol/lit respectively.


Domala R.,Stpeters Institute Of Pharmaceutical Science | Eedara B.B.,Stpeters Institute Of Pharmaceutical Science | Dhurke R.K.,Stpeters Institute Of Pharmaceutical Science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: The objective of present work was to formulate and evaluate an oral pulsatile drug delivery system to achieve time release of felodipine, based on chronopharmaceutical approach for management of hypertension. Methods: The strategy adopted was to improve solubility of felodipine by using novel solubilizers like Sepitrap 4000 and Sepitrap 80 in different ratios. Core tablets (CR) of felodipine were prepared by direct compression method using optimum ratio of felodipine and solubilizers. CR tablet was then press coated using different grades of HPMC like E5, E15 and E50 in varying ratios. Pulsatile tablets were evaluated for pre-compressional and post-compressional parameters. Swelling studies and water uptake studies were also carried out to select optimum concentration of polymer that could provide desired lag time. Results: CR tablet formulated with Sepitrap 4000 and Sepitrap 80 (1:1 ratio) showed 100.16±2.06% release in 15 and 30 min respectively. On the basis of in vitro release profile it was found that the optimized formulation F6showed the lag time of about 7.5h which showed compliance with chronotherapeutic objective of hypertension. A direct correlation between swelling and lag time was observed from swelling index and water uptake studies. Solid state characterization (FTIR, XRD studies) indicated that there was decrease in crystallinity of the drug with no interaction between drug and excipients. Conclusion: Pulsatile drug delivery system is capable of delivering the drug when and where it is required. Drug is released as a burst after a lag time (during peak morning hours) giving relief from morning surge hypertension effect.


Parney S.,Stpeters Institute Of Pharmaceutical Science | Dhurke R.K.,Stpeters Institute Of Pharmaceutical Science
Journal of Pharmaceutical Investigation | Year: 2014

The purpose of the research work was to develop microemulsion (ME) of hydrocortisone acetate (HCA) using natural penetration enhancers and to determine its possibility in effective dermal delivery. Eucalyptus oil, clove oil and lemon grass oil were selected as natural penetration enhancers and pseudo-ternary phase diagrams were plotted using Tween 80 as surfactant and ethanol as cosurfactant. ME of each penetration enhancer was optimized using three factors, three levels Box–Behnken design, with independent variables as penetration enhancer, Tween 80 and ethanol. Formulations were assessed for percentage drug release as dependent variable. Response of these formulations decreased as the concentration of oil ranged from high to low and the response showed positive effect with increase in concentration of Tween 80 and ethanol. The globule size of optimized batches of eucalyptus oil, clove oil and lemon grass oil were found to be 226.1, 129.04 and 818.9 nm respectively. Optimized batches of MEs were then incorporated in carbopol 940 to form ME based gel without affecting their structure. Ex vivo permeation studies showed that amount of drug permeated from ME based gels was less than ME formulation indicating greater retention of HCA into skin layers. Retention of drug in skin layers both dermis and epidermis was higher for all three natural penetration enhancer. Hence natural penetration enhancers can be used for effective delivery of topical corticosteroids to the skin for improved treatment of several skin diseases and can be a better choice over synthetic penetration enhancers in terms of safety. © 2014, The Korean Society of Pharmaceutical Sciences and Technology.


Koteswari P.,S.N.Vanitha Pharmacy Mahavidyalaya | Ramakrishna S.,Indian Institute of Chemical Technology | Reddy V.P.,Stpeters Institute Of Pharmaceutical Science | Kaur G.S.,S.N.Vanitha Pharmacy Mahavidyalaya | Narasu L.M.,JNTUH College of Engineering
Journal of Chemical and Pharmaceutical Sciences | Year: 2011

Objective of the present study was the development and validation of a simple RP-HPLC method for the estimation of felodipine in bulk and pharmaceutical dosage forms. The analysis was carried out by using phenomenex C-8 column in isocratic mode with the mobile phase consisting of Acetonitrile and water in the ratio of 31:69 v/v at a flow rate of 1ml/min. The eluent was detected for 240 nm. The retention time of the drug was 4.28 minutes. The proposed method was statistically validated and found that it is simple, accurate, precise, robust, and suitable for the routine analysis of pharmaceutical formulations.


Koteswari P.,S.N.Vanitha Pharmacy Mahavidyalaya | Ramakrishna S.,Indian Institute of Chemical Technology | Reddy V.P.,Stpeters Institute Of Pharmaceutical Science | Janani V.R.,S.N.Vanitha Pharmacy Mahavidyalaya | And 2 more authors.
Journal of Chemical and Pharmaceutical Sciences | Year: 2011

Objective of the present study was the development and validation of a simple RP-HPLC method for the estimation of carvedilol in bulk and pharmaceutical dosageforms. The analysis was carried out by using phenomenex C-18 column in isocratic mode with the mobile phase consisting of Acetonitrile and phosphate buffer in the ratio of 69:31 v/v at a flow rate of 1ml/min. The eluent was detected for 242 nm . The retention time of the drug was 3.57min. The proposed method was statistically validated and found that it is simple, accurate, precise, robust, and suitable for the routine analysis of pharmaceutical formulations.


Roy S.,NSHM Knowledge Campus | Sannigrahi S.,NSHM Knowledge Campus | Vaddepalli R.P.,Stpeters Institute Of Pharmaceutical Science | Ghosh B.,Medical College Kolkata | Pusp P.,Galaxy Concept Pvt. Ltd.
Inflammation | Year: 2012

The present study was designed to evaluate the combinatory effect of methotrexate (MTX) and epigallocatechin (EGCG) on the progression of adjuvant-induced arthritis in rats. Adjuvant arthritis (AA) was induced by a single intradermal injection of Freund's complete adjuvant. AA rats were treated with methotrexate (0.3 mg/kg) thrice a week, EGCG (100 mg/kg) daily, and combination of MTX and EGCG thrice a week for a period of 28 days. Paw swelling changes and histopathological and radiographic analysis was assessed to evaluate the antiarthritic effect. Lipid peroxidation and antioxidant enzyme activities in joint tissue homogenate were performed to observe the modulation of antioxidant status along the expression of different pro-inflammatory cartilage cytokines like TNF-a and IL-6.MTX and EGCG combination potentiated both the antiarthritic (decrease of hind paw volume) and the antioxidant effect (SOD, GSH, and catalase) as well as suppression of lipid peroxidation. Combination therapy of MTX and EGCG significantly inhibited the development phase of arthritis, which is supported by histopathological, radiographical, and attenuation of overexpression of cartilage cytokines. EGCG act as potent antioxidant and immunomodulator, suggesting that combined administration of MTX along with EGCG suppressed the development phase of arthritic progression in rats. © 2012 Springer Science+Business Media, LLC.


Nath A.R.,Osmania University | Reddy M.S.,Stpeters Institute Of Pharmaceutical Science
E-Journal of Chemistry | Year: 2012

The novel 2-[ (E)- 2-aryl-1-ethenyl]-3- (2-sulfanyl-1H-benzo[d]imidazole-5- yl)-3, 4- dihydro-4-quinolinones (4a-j) analogs were synthesized by Knoevenagel condensation of a solution of 2-methyl-3- (2-sulfanyl-1H-benzo[d]imidazole-5-yl) -3, 4-dihydro-4-quinazolinone (3) with aromatic aldehyde in presence of catalytic amount of piperidine . Compounds (4a-j) showed significant biological activity against all the standard strains. All the synthesized compounds were characterized on the basis of their IR, 1H NMR, MASS spectroscopic data and elemental analyses. All the compounds have been tested for antimicrobial and antifungal activity by the cup-plate method.


Yasmeen N.,Catholic University of Leuven | Sujatha K.,Stpeters Institute Of Pharmaceutical Science
International Journal of Phytomedicine | Year: 2013

The present study was designed to investigate the anti-inflammatory activity of the ethanolic extract of whole plant of Desmodium gangeticum. Investigations were done by Carrageenan-induced paw oedema method in rats. Here the extract at the 100 & 200mg/kg dose level showed 36.68% (p<0.001) inhibition of edema volume at the end of 4hr.The extract reduced significantly the formation of oedema induced by carrageenan. Inflammatory diseases including different types of rheumatic diseases are very common throughout the world. Therefore the search for a better tolerated anti-inflammatory agent appears to be a necessity. Desmodium gangeticum is used as a folk medicine for the treatment of inflammation in India. Present study revealed that the plant Desmodium gangeticum possesses a significant anti-inflammatory activity as evidenced in carrageenan induced paw edema method, which supports the folkloric claim of the anti-inflammatory activity of the plant.

Loading Stpeters Institute Of Pharmaceutical Science collaborators
Loading Stpeters Institute Of Pharmaceutical Science collaborators