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Vijayanagar, India

The leaves of Stevia rebaudiana Bert, is commonly known as hypocaloric bio-sweeteners. It can be used in multiple health diseases and traditionally the leaves of Stevia are used as sugar substitute. The present study was carried out to evaluate the hepatoprotective activity of Stevia rebaudiana leaves against thioacetamide-induced (s.c.) hepatotoxicity. Aqueous leaves extract of Stevia rebaudiana (AESR) at dose levels of 200 and 400 mg/kg/day were evaluated. Oral administration of Stevia leaves extract at 400 mg/kg resulted in a significant reduction in aspartate transaminase, (AST, 131.1±3.0 IU/L), alanine aminotransferase (ALT, 62.2±1.8 IU/L), gamma glutamyl transpeptidase (GGT, 13.0±0.3 IU/L), alkaline phosphatase (ALP, 197.4±3.2 IU/L) and total bilirubin (0.23±0.0 mg/dL) compared to control. The glutathione (GSH) and A IDA levels of the liver tissue samples were also measured. Histology of the liver sections of the animals treated with the extract also showed dose-dependent reduction of necrosis. The present investigation revealed the hepatoprotective activity of the aqueous leaves extract of Stevia rebaudiana against thioacetamide induced hepatotoxicity. Source


Vijaya Bhaskar S.,Stjohns Pharmacy College | Leema A.V.,Stjohns Pharmacy College | George A.,Stjohns Pharmacy College | Einstein J.W.,Stjohns Pharmacy College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

A simple, reliable, accurate, and sensitive method for the determination of Mycophenolate Mofetil (MMF) was developed and validated in tablets and capsules. The maximum absorbance of Mycophenolate Mofetil was found to be 700nm.The linearity was observed in the range of 1μg/ml to 45 μg/ml in hydrochloric acid. Mycophenolate mofetil in 0.1N hydrochloric acid was estimated at 700 nm with the help of 0.008M potassium ferri cyanide and 0.1M ferric chloride in 0.1M hydrochloric acid. The method was found to have high degree of accuracy and precision in both inter and intra day. © 2010 RJPBCS. Source

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