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Vinodkumar C.S.,stitute Of Medical Science And Research Center | Srinivasa H.,St Johns Medical College | Basavarajappa K.G.,stitute Of Medical Science And Research Center | Geethalakshmi S.,Madras Medical College | Bandekar N.,stitute Of Medical Science And Research Center
Indian Journal of Pathology and Microbiology | Year: 2011

Introduction: While foot infections in persons with diabetes are initially treated empirically, therapy directed at known causative organisms may improve the outcome. Many studies have reported on the bacteriology of diabetic foot infections (DFIs), but the results have varied and have often been contradictory. The purpose of the research work is to call attention to a frightening twist in the antibiotic-resistant Enterococci problem in diabetic foot that has not received adequate attention from the medical fraternity and also the pharmaceutical pipeline for new antibiotics is drying up. Materials and Methods: Adult diabetic patients admitted for lower extremity infections from July 2008 to December 2009 in the medical wards and intensive care unit of medical teaching hospitals were included in the study. The extent of the lower extremity infection on admission was assessed based on Wagner's classification from grades I to V. Specimens were collected from the lesions upon admission prior to the initiation of antibiotic therapy or within the first 48 h of admission. Results: During the 18-month prospective study, 32 strains of Enterococcus spp. (26 Enterococcus faecalis and 06 E. faecium) were recovered. Antibiotic sensitivity testing was done by Kirby-Bauer's disk diffusion method. Isolates were screened for high-level aminoglycoside resistance (HLAR). A total of 65.6% of Enterococcus species showed HLAR. Multidrug resistance and concomitant resistance of HLAR strains to other antibiotics were quite high. None of the Enterococcus species was resistant to vancomycin. Conclusion: Multidrug-resistant Enterococci are a real problem and continuous surveillance is necessary. Today, resistance has rendered most of the original antibiotics obsolete for many infections, mandating the development of alternative anti-infection modalities. One of such alternatives stemming up from an old idea is the bacteriophage therapy. In the present study, we could able to demonstrate the viable phages against MDR E. faecalis.

Shashikant,stitute of Medical science and Research Center | Patil S.M.,DNB in Medicine in Essential
Journal of Clinical and Diagnostic Research | Year: 2015

Herpes zoster is a clinical manifestation which results from reactivation of latent VZV (Varicella zoster virus) present in the sensory root ganglia. Disseminated herpes zoster has been reported in immune-compromised patients such as patient on cancer chemotherapy, HIV (Human immune deficiency virus) infection, systemic corticosteroid therapy. However, we report a case of disseminated herpes zoster infection in an uncontrolled diabetic patient. A brief review of literature on this topic has been bestowed. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

Mallikarjuna Swamy C.M.,stitute of Medical science and Research Center | Arathi C.A.,Sri Siddhartha Medical College | Kodandaswamy C.R.,Sri Siddhartha Medical College
Journal of Cytology | Year: 2011

Background: The evaluation and management of various hepatic lesions is a common clinical problem and their appropriate clinical management depends on accurate diagnoses. Aims: To study the cytomorphological features of distinctive non-neoplastic and neoplastic lesions of the liver and to evaluate the sensitivity, specificity and diagnostic accuracy of ultrasonography (USG)-guided fine needle aspiration cytology (FNAC) in the diagnosis of liver diseases. Materials and Methods: Seventy - two patients with evidence of liver diseases underwent USG-guided, percutaneous FNAC. Cytomorphological diagnoses were correlated with clinical, biochemical and radiological findings, histopathological diagnoses and follow-up information. Results: The age of the patients ranged from eight months to 90 years with 48 males (66.67%) and 24 females (33.33%). Of the 72 cases, the cytological diagnosis was rendered in 71 patients and smears were inadequate for interpretation in one case. Neoplastic lesions (68.06%) were more common than non-neoplastic lesions (30.56%). The majority of the neoplastic lesions were hepatocellular carcinomas (36.12%) followed by metastatic adenocarcinomas (19.45%). Among non-neoplastic lesions, cirrhosis was the commonest lesion (8.34%). The overall diagnostic accuracy of FNAC was 97.82% with a sensitivity and specificity of 96.87 and 100% respectively. Conclusion: USG-guided FNAC of the liver is a safe, simple, cost-effective and accurate method for cytological diagnosis of hepatic diffuse, focal/nodular and cystic lesions with good sensitivity and specificity.

PubMed | Infosys and stitute of Medical science and Research Center
Type: Journal Article | Journal: Indian journal of anaesthesia | Year: 2016

Hypotensive anaesthesia reduces intra-articular bleed and promotes visualisation during arthroscopy. The haemodynamic effects of inhalational agents isoflurane and sevoflurane were studied extensively, and both were found to reduce mean arterial pressures (MBP) to an equivalent magnitude. We investigated the relative ability of isoflurane vis-a-vis sevoflurane to maintain the target systolic blood pressure (SBP) in patients undergoing shoulder arthroscopic procedures.In a prospective randomised study, 59 patients in two groups of 30 and 29 patients each received concomitant general anaesthesia (1.2-1.5 MAC of isoflurane and sevoflurane) and interscalene brachial plexus block. Nitrous oxide was used in both groups. Intraoperatively, serial blood pressure recordings of SBP, diastolic blood pressure (DBP), MBP and heart rates were done at every 3Lower mean SBP and DBPs were recorded for isoflurane patients as compared to sevoflurane (Isoflurane provides better intraoperative haemodynamic status vis-a-vis sevoflurane in patients undergoing shoulder arthroscopic surgery with preliminary interscalene blockade. The PCI can be a useful additional medical data analysis tool.

Vasudeva Murthy C.R.,stitute Of Medical Science And Research Center
Journal of Chinese Clinical Medicine | Year: 2011

This study was conducted to document the frequency ABO & rhesus blood groups in potential male blood donor belong to south area of Karnataka. Design: Observational cross sectional study. Settings: Blood transfusion center at Davangere, Karnataka. Methods The data of blood donors from July 2009 to December 2009. Results Total number of donors studied was 3,048. The commonest blood group was 0 present in 37. 87% followed by B in 29. 98%, A in 23. 88% and AB in 8. 29%. While 95. 41% donors were Rh positive and 4. 59% was Rh negative. The maximum donors were between in age group 20-39 years. The maximum prevalence of hemoglobin % ranges from 13. 0-13. 9 about 2,983 (75. 11%). The maximum prevalence of weight among the donors was between 60 to 69 kg about 1,201 (39. 40%) and the least weight appears between 80 to 90 kg about 254 (8. 4%). Conclusion Blood group 0 is the commonest ABO blood group and 95. 41% are Rh + in this area, the maximum prevalence of donors in age group, Hb% and Weight are 20. 39 years, 13. 0-13. 5 gm% and 50-69 kg respectively.

Adinarayan M.,stitute Of Medical Science And Research Center | Krishnamurthy S.P.,stitute Of Medical Science And Research Center
Indian Journal of Dermatology | Year: 2011

Background: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), in combination, are referred to as nonmelanoma skin cancers (NMSCs). NMSC is not as extensively studied in the Asian population as it is in the Caucasian population. Aim: This study sought to evaluate the clinical and histopathologic aspects of NMSC from cases of cutaneous malignancies. Materials and Methods: The present study is a descriptive analysis of NMSC specimens seen at Department of Pathology, SSIMS and RC, Davangere. Histologically diagnosed NMSC, i.e. BCC and SCC specimens from January 2005 to December 2009 were analyzed according to site distribution, risk factors and histological variants. Results: Of the various specimens received during the 5year study period, 60 were histologically categorized as skin malignancies, of which 31(51.6%) cases were of NMSC. SCC was the most common NMSC constituting 26 (83.9%) cases and 5 NMSC cases (16.1%) were of BCC. The most common incidence was among the age group 60-80 years (80%) for BCC and 40-60 years (50%) for SCC. Head and neck was the most common site of presentation with predilection for face. Forty-six percent of SCC was histologically categorized as well differentiated, 42.3% as moderately differentiated and 11.5% as poorly differentiated. Most common histological variant of BCC was solid (nodular) type. Conclusion: NMSC often associated with greater morbidity, necessitating increased efforts to assess risk factors in individuals, to encourage periodic self-examination and professional evaluation of skin and to optimize strategies for earlier diagnosis and treatment.

Sushil Kumar Sompur V.,stitute of Medical science and Research Center
African Journal of Psychiatry (South Africa) | Year: 2014

Depression is the leading cause of disability among women in the world, frequently under recognized and inadequately treated. In spite of the different antidepressants available at the present time, they are far from ideal and show a similar slow & frequently incomplete response. This case report describes a 75 yr. old woman with persistent depressive disorder with intermittent major depressive episodes lasting for almost 40 years who was inadequately treated. It highlights the effectiveness of augmentation of low dose Aripiprazole in long standing persistent depressive disorder with intermittent major depressive episodes. After optimization of treatment with a known anti-depressant the augmentation strategy can produce a therapeutic response as early as 2 weeks with more than 50% reduction in symptoms on PHQ-9 scores. © 2014, Sushil KSV.

Vasudeva M.C.R.,stitute Of Medical Science And Research Center
Journal of Chinese Clinical Medicine | Year: 2010

Objective To study the antinociceptive activity of four selective serotonin reuptake inhibitors (SSRIs) viz., fluoxetine, fluoxamine, peroxetine and sertraline. Methods Antinociceptive activity was studied using hot water immersion test, tail flick method and hot plate method in albino rats. Drugs and normal saline (control) were given intraperitonially and the results were analyzed with suitable statistical application. Results Fluoxetine (10 mg/kg), fluoxamine (25 mg/kg), peroxetine (10 mg/kg) and sertraline (10 mg/kg) produced significant antinociceptive ffect in all the three experimental models (P < 0.001). Fluoxamine produced maximum effect among the four SSRIs. Conclusion As serotonin is an important mediator of pain, these SSRIs have shown considerable antinociceptive activity. These may be used as co-analgesics in diabetic neuropathy, diafferentiation pain, migraine and also in the patients of depression with pain. Further studies may widen the horizon of usage of SSRIs in the management of pain.

Mantur V.S.,KLE University | Vasudeva M.C.R.,stitute Of Medical Science And Research Center
Journal of Chinese Clinical Medicine | Year: 2010

Objective There is a large and relative consistent literature on the effects of psychological stress on immune function in humans. The effect of psychological stress can alter the blood cells parameters such as white blood cell in healthy individuals. The assay of leukocyte in the peripheral blood may provide information on the immune status. Estimations of white blood cell were carried out in both absence and presence of examination stress. Comparison of pre-examination results to the results taken during exams was done in both males and females. It was observed that academic examination stress induces changes in the distribution of white blood cell, which indicate immune activation and which are probably due to stress-induced production of cytokines. In this present article, an effort is made to study the effect of psychological stress on leukocyte distribution in both males and females were studied by means of peripheral blood cell counts. Methods Out of 200 students enrolled, 150 students were selected. The study was conducted at department of physiology, S. S. Institute of Medical Sciences and Research Center, Davangere, India. Selection was done 5 months prior to the first terminal examination; they were subjected to preliminary medical checkup including blood pressure and temperature recordings. The students receiving long term medications are excluded from the study. Results When the differential counts in both males and female were compared, students showed significantly higher number of all the subsets of leucocytes. There is definite raise in the lymphocytes, neutrophil, monocytes, basophils and eosinophil during the examination period than earlier. Conclusion The present data indicate psychological stress increases leucocytes counts.

Vasudeva Murthy C.R.,stitute Of Medical Science And Research Center
Journal of Chinese Clinical Medicine | Year: 2011

Objective Hepatitis B is one of the transmissible diseases. The prevalence of this infection varies across the different geographies. Thus by studying the incidence and its relation to blood groups helps in planning strategies to prevent its further transmission. This study was aims to determine the frequency of the ABO and rhesus blood group among potential male blood donors belonging to Davangere, south Karnataka. Methods All donors are pre screened by questionnaire provided the institution and passed the physical examinations conducted by the physi -cian in charge. Blood donor' s data results of HBsAg were obtained using the blood banks records of donors and al -so collected blood groups of all the donors. These results then distributed in different age groups, blood groups and Rh factors were calculated. Results In our study the HBsAg occur in the age range was between 20-29 about 159 (54. 26%) and least between 40-49 about 31 (10%) and high prevalence of HBsAg was found in O group about 111(37. 88%) and least blood group AB about 26 (08. 87%). Prevalence of Rh positive factors was 283 (96. 58%) and negative factors were 10(3. 42%). Conclusion In Conclusion,the study showed that no particu-lar blood group type could be linked to the occurrence of HBsAg infections and it also emphasized the necessary to screen HBsAg among all blood donors.

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