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PubMed | U.S. Food and Drug Administration and Stiftung Tierarztliche Hochschule Hanover
Type: Journal Article | Journal: Genome announcements | Year: 2016

We introduce draft genome sequences of strains CDC1121-73 (human bronchial wash isolate) and GK1025 (powdered infant formula manufacturing facility isolate), which are both malonate-positive Cronobacter sakazakii serogroup O:2, sequence type 64. Assemblies for these strains have sizes of 4,442,307 and 4,599,266bp and % G+C contents of 56.9 and 56.7, respectively.


PubMed | Friedrich - Schiller University of Jena and Stiftung Tierarztliche Hochschule Hanover
Type: | Journal: BMC veterinary research | Year: 2015

Sonographic ophthalmic examinations have become increasingly important in veterinary medicine. If the velocity of ultrasound in ocular tissues is known, the A-mode ultrasound method may be used to determine the axial intraocular distances, such as anterior chamber depth, lens thickness, axial length of the vitreous and axial globe length, which are required for intraocular lens (IOL) power calculations. To the authors knowledge, the velocity of ultrasound in the ocular tissues of the horse was not previously determined. In the present study, 33 lenses, 29 samples of aqueous and 31 of vitreous from 35 healthy equine eyes have been examined. The corresponding ultrasound velocities are reported in dependence of age, temperature, gender and elapsed time after enucleation.The velocity of ultrasound at 36C in equine aqueous, lens and vitreous are 1529 10 m/s, 1654 29 m/s and 1527 16 m/s respectively, and the corresponding conversion factors are 0.998 0.007, 1.008 0.018 and 0.997 0.010. A linear increase of the speed of ultrasound with increasing temperature has been determined for aqueous and vitreous. No temperature dependence was found for the speed of ultrasound in the lens. The ultrasound velocity did not significantly differ (95%) on the basis of gender, age or time after enucleation during the first 72 hours after death.Compared to human eyes, the ultrasound velocity in equine lental tissue deviates by one percent. Therefore, axial length measurements obtained with ultrasound velocities for the human eye must be corrected using conversion factors. For the aqueous and vitreous, deviations are below one percent and can be neglected in clinical settings.


Osigus H.-J.,Stiftung Tierarztliche Hochschule Hanover | Eitel M.,Stiftung Tierarztliche Hochschule Hanover | Eitel M.,University of Hong Kong | Bernt M.,University of Leipzig | And 3 more authors.
Molecular Phylogenetics and Evolution | Year: 2013

Unraveling the base of metazoan evolution is of crucial importance for rooting the metazoan Tree of Life. This subject has attracted substantial attention for more than a century and recently fueled a burst of modern phylogenetic studies. Conflicting scenarios from different studies and incongruent results from nuclear versus mitochondrial markers challenge current molecular phylogenetic approaches. Here we analyze the presently most comprehensive data sets of mitochondrial genomes from non-bilaterian animals to illuminate the phylogenetic relationships among early branching metazoan phyla. The results of our analyses illustrate the value of mitogenomics and support previously known topologies between animal phyla but also identify several problematic taxa, which are sensitive to long branch artifacts or missing data. © 2013 Elsevier Inc.


Rehm P.,Biozentrum Grindel and Zoologisches Museum | Borner J.,Biozentrum Grindel and Zoologisches Museum | Meusemann K.,Zoologisches Forschungsmuseum Alexander Koenig | von Reumont B.M.,Zoologisches Forschungsmuseum Alexander Koenig | And 4 more authors.
Molecular Phylogenetics and Evolution | Year: 2011

Molecular sequences do not only allow the reconstruction of phylogenetic relationships among species, but also provide information on the approximate divergence times. Whereas the fossil record dates the origin of most multicellular animal phyla during the Cambrian explosion less than 540. million. years. ago. (mya), molecular clock calculations usually suggest much older dates. Here we used a large multiple sequence alignment derived from Expressed Sequence Tags and genomes comprising 129. genes (37,476 amino acid positions) and 117. taxa, including 101. arthropods. We obtained consistent divergence time estimates applying relaxed Bayesian clock models with different priors and multiple calibration points. While the influence of substitution rates, missing data, and model priors were negligible, the clock model had significant effect. A log-normal autocorrelated model was selected on basis of cross-validation. We calculated that arthropods emerged ~600. mya. Onychophorans (velvet worms) and euarthropods split ~590. mya, Pancrustacea and Myriochelata ~560. mya, Myriapoda and Chelicerata ~555. mya, and 'Crustacea' and Hexapoda ~510. mya. Endopterygote insects appeared ~390. mya. These dates are considerably younger than most previous molecular clock estimates and in better agreement with the fossil record. Nevertheless, a Precambrian origin of arthropods and other metazoan phyla is still supported. Our results also demonstrate the applicability of large datasets of random nuclear sequences for approximating the timing of multicellular animal evolution. © 2011 Elsevier Inc.


Tenhaven C.,Stiftung Tierarztliche Hochschule Hanover
GMS Zeitschrift für medizinische Ausbildung | Year: 2013

Introduction: Informal and formal lifelong learning is essential at university and in the workplace. Apart from classical learning techniques, Web 2.0 tools can be used. It is controversial whether there is a so-called net generation amongst people under 30. Aims: To test the hypothesis that a net generation among students and young veterinarians exists. Methods: An online survey of students and veterinarians was conducted in the German-speaking countries which was advertised via online media and traditional print media. Results: 1780 people took part in the survey. Students and veterinarians have different usage patterns regarding social networks (91.9% vs. 69%) and IM (55.9% vs. 24.5%). All tools were predominantly used passively and in private, to a lesser extent also professionally and for studying. Outlook: The use of Web 2.0 tools is useful, however, teaching information and media skills, preparing codes of conduct for the internet and verification of user generated content is essential.


Dilly M.,Clinical Skills Laboratory | Gruber C.,Stiftung Tierarztliche Hochschule Hanover
GMS Zeitschrift fur Medizinische Ausbildung | Year: 2016

Since 2012, skills labs have been set up to teach practical skills at veterinary training facilities in the German-speaking world. In addition to didactic considerations, ethical points of view in terms of animal protection form the basis of the increasing significance of skills labs in veterinary medicine. Not least because of the quality standards in veterinary medicine training which apply across Europe, the link between veterinary medicine training facilities is particularly significant when it comes to the setting up and development of skills labs. The Committee on Veterinary Medicine is therefore not only interested in exchange and cooperation within veterinary medicine, but also sees an opportunity for mutual gain in the link with the Society for Medical Education Committee “Practical Skills”. © 2016 Dilly et al.


Short-time variations in the concentration of airborne bacteria and mould spores were investigated at different locations (urban, rural, forest, hayfield) in the northern part of Germany using different sampling techniques (filter, Impinger, Coriolis®-Sampler, impactor, Bio-aerosol spectrometer). The bacteria concentrations changed sometimes by the third power of ten within one hour. Even from one minute to another the number of bacteria (colony forming units, cfu) increased 500-fold as observed at the sampling place in the forest. In contrast, concentrations of mould spores varied by a factor 3 only. These sudden fluctuations clearly influenced the results obtained by different sampling methods when short-term air samples were taken. They seem to have also a significant influence on long-term sampling, as e. g. the numbers of cfu obtained by impingement can differ between two 30-minutes samplings up to the power of ten. These reported large fluctuations should be taken into account when investigating and assessing the so-called natural background concentrations of airborne bacteria in a certain region.


Eitel M.,Stiftung Tierarztliche Hochschule Hanover | Guidi L.,Life and Environment science | Hadrys H.,Stiftung Tierarztliche Hochschule Hanover | Hadrys H.,Yale University | And 3 more authors.
PLoS ONE | Year: 2011

Unraveling animal life cycles and embryonic development is basic to understanding animal biology and often sheds light on phylogenetic relationships. A key group for understanding the evolution of the Metazoa is the early branching phylum Placozoa, which has attracted rapidly increasing attention. Despite over a hundred years of placozoan research the life cycle of this enigmatic phylum remains unknown. Placozoa are a unique model system for which the nuclear genome was published before the basic biology (i.e. life cycle and development) has been unraveled. Four organismal studies have reported the development of oocytes and one genetic study has nourished the hypothesis of sexual reproduction in natural populations at least in the past. Here we report new observations on sexual reproduction and embryonic development in the Placozoa and support the hypothesis of current sexual reproduction. The regular observation of oocytes and expressed sperm markers provide support that placozoans reproduce sexually in the field. Using whole genome and EST sequences and additional cDNA cloning we identified five conserved sperm markers, characteristic for different stages in spermatogenesis. We also report details on the embryonic development up to a 128-cell stage and new ultrastructural features occurring during early development. These results suggest that sperm and oocyte generation and maturation occur in different placozoans and that clonal lineages reproduce bisexually in addition to the standard mode of vegetative reproduction. The sum of observations is best congruent with the hypothesis of a simple life cycle with an alternation of reproductive modes between bisexual and vegetative reproduction. © 2011 Eitel et al.


Tenhaven C.,Stiftung Tierarztliche Hochschule Hanover | Tipold A.,Stiftung Tierarztliche Hochschule Hanover | Fischer M.R.,Klinikum der LMU Munich | Ehlers J.P.,Stiftung Tierarztliche Hochschule Hanover
GMS Zeitschrift fur Medizinische Ausbildung | Year: 2013

Introduction: Informal and formal lifelong learning is essential at university and in the workplace. Apart from classical learning techniques, Web 2.0 tools can be used. It is controversial whether there is a so-called net generation amongst people under 30. Aims: To test the hypothesis that a net generation among students and young veterinarians exists. Methods: An online survey of students and veterinarians was conducted in the German-speaking countries which was advertised via online media and traditional print media. Results: 1780 people took part in the survey. Students and veterinarians have different usage patterns regarding social networks (91.9% vs. 69%) and IM (55.9% vs. 24.5%). All tools were predominantly used passively and in private, to a lesser extent also professionally and for studying. Outlook: The use of Web 2.0 tools is useful, however, teaching information and media skills, preparing codes of conduct for the internet and verification of user generated content is essential. © 2013 Tenhaven et al.


PubMed | Clinical Skills Laboratory and Stiftung Tierarztliche Hochschule Hanover
Type: Journal Article | Journal: GMS journal for medical education | Year: 2016

Since 2012, skills labs have been set up to teach practical skills at veterinary training facilities in the German-speaking world. In addition to didactic considerations, ethical points of view in terms of animal protection form the basis of the increasing significance of skills labs in veterinary medicine. Not least because of the quality standards in veterinary medicine training which apply across Europe, the link between veterinary medicine training facilities is particularly significant when it comes to the setting up and development of skills labs. The Committee on Veterinary Medicine is therefore not only interested in exchange and cooperation within veterinary medicine, but also sees an opportunity for mutual gain in the link with the Society for Medical Education Committee Practical Skills.

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