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Tenhaven C.,Stiftung Tierarztliche Hochschule Hanover
GMS Zeitschrift für medizinische Ausbildung | Year: 2013

Introduction: Informal and formal lifelong learning is essential at university and in the workplace. Apart from classical learning techniques, Web 2.0 tools can be used. It is controversial whether there is a so-called net generation amongst people under 30. Aims: To test the hypothesis that a net generation among students and young veterinarians exists. Methods: An online survey of students and veterinarians was conducted in the German-speaking countries which was advertised via online media and traditional print media. Results: 1780 people took part in the survey. Students and veterinarians have different usage patterns regarding social networks (91.9% vs. 69%) and IM (55.9% vs. 24.5%). All tools were predominantly used passively and in private, to a lesser extent also professionally and for studying. Outlook: The use of Web 2.0 tools is useful, however, teaching information and media skills, preparing codes of conduct for the internet and verification of user generated content is essential. Source


Milberg P.,University of Munster | Milberg P.,Universitatsklinikum Munster | Klocke R.,University of Munster | Frommeyer G.,University of Munster | And 12 more authors.
Basic Research in Cardiology | Year: 2011

G-CSF (granulocyte colony-stimulating factor) treatment has been shown to cause beneficial effects including a reduction of inducible arrhythmias in rodent models of ischemic cardiomyopathy. The aim of the present study was to test whether these effects do also apply to pacing-induced non-ischemic heart failure. In 24 female rabbits, heart failure was induced by rapid ventricular pacing. 24 rabbits were sham operated. The paced rabbits developed a significant decrease of ejection fraction. 11 heart failure rabbits (CHF) and 11 sham-operated (S) rabbits served as controls, whereas 13 sham (S-G-CSF) and 13 heart failure rabbits (CHF-G-CSF) were treated with 10 μg/kg G-CSF s.c. over 17 ± 4 days. G-CSF treatment caused a ∼25% increased arterial and capillary density and a ∼60% increased connexin 43 expression in failing hearts. In isolated, Langendorff-perfused rabbit hearts eight monophasic action potential recordings showed prolongation of repolarization in CHF as compared with controls in the presence of the QT prolonging agent erythromycin (+33 ± 12 ms; p < 0.01). Moreover, a significant increase in dispersion of repolarization contributed to a significantly higher rate of ventricular tachyarrhythmias in CHF. G-CSF-pre-treated hearts showed a further increase in prolongation of repolarization as compared with S and CHF. The further increase in dispersion of repolarization [S-G-CSF: +23 ± 9 ms (spatial), +13 ± 7 ms (temporal); CHF-G-CSF: +38 ± 14 ms (spatial), +10 ± 4 ms (temporal); p<0.05 as compared with S and CHF], increased the incidence of ventricular tachyarrhythmias. In summary, chronic G-CSF treatment has moderate beneficial effects on parameters potentially related to hemodynamic function in the nonischemic rabbit CHF model. However, a significant reduction of repolarization reserve might seriously challenge its suitability as a therapeutic agent for chronic CHF therapy. © Springer-Verlag 2011. Source


Hamedy A.,University of Leipzig | Fehlhaber K.,Heideweg 10 | Glunder G.,Stiftung Tierarztliche Hochschule Hanover | Alter T.,Free University of Berlin
Fleischwirtschaft | Year: 2013

Today, thermophilic Campylobacter spp. (besides Salmonella] represent one of the most common sources of human bacterial gastrointestinal infection. The main source of human C. jejuni infections is the consumption of insufficient heated chicken meat. The aims of the investigations presented here were to detect the Campylobacter genotype distribution in poultry flocks by applying AFLP analysis and to describe a potential carry-over of Campylobacter strains among sequential and adjacent poultry flocks. For the above mentioned purposes, 19 flocks of four poultry species were monitored to investigate the distribution and spread of Campylobacter genotypes between sequential and adjacent flocks. Caecal and liver samples were obtained at frequent intervals from birds of all flocks and these samples were examined for Campylobacter. The amplified fragment length polymorphism (AFLP) analysis was performed to genotype Campylobacter isolates. Of the 1643 caecal and liver samples investigated, 452 (27.5%) caecal samples and 11 (0.7%) liver samples contained Campylobacter. Of the caecal isolates 76.3% were identified as C. jejuni and 23.7% were identified as C. coli. Poultry flocks were largely colonised by more than one AFLP type and an intense exchange of Campylobacter genotypes between different poultry flocks occurred. The results show clearly that poultry and poultry meat are regarded as one of the main sources of thermophilic Campylobacter spp. infection in humans in the food chain. This is evident not only from the high rate of occurrence of these pathogens, but also from the often-high quantitative exposure samples. The risk of a foodborne infection is also enhanced by the comparatively very low minimum infectious dose for humans. At present, a complete elimination of thermophilic Campylobacter spp. from the food chain appears practically unreachable. This difficulty is reduced by the results of genetic strain diversity, because they suggest the existence of a variety of input sources. Source


Linke I.,Hannover Medical School | Fadeeva E.,Laser Zentrum Hannover e.V. | Scheper V.,Hannover Medical School | Esser K.-H.,Stiftung Tierarztliche Hochschule Hanover | And 4 more authors.
Physica Status Solidi (A) Applications and Materials Science | Year: 2015

A cochlear implant is a surgically implanted device that helps to restore hearing for most severe hearing impaired patients. During the first 2-3 weeks after implantation of a cochlear implant electrode array, the electrical impedance at the electrode contacts increases. This increase is typically explained by the formation of fibrous tissue around the electrode array. To improve the electrode nerve interface in these patients, it is aimed at a reduction of tissue formation around the electrode array after implantation. Previously we have demonstrated that nanostructuring of platinum surfaces can inhibit fibroblast growth in vitro. In the current study we generated nanostructures directly on the surfaces of cochlear implant electrodes and tested their potential to reduce connective tissue formation around the electrode array in vivo by means of electrophysiological measurements. Guinea pigs were implanted with unstructured control or surface structured electrode arrays for 4 weeks. Impedance measurements were performed during the first 2 weeks daily, later weekly. Recorded impedances were typically lower for surface functionalized electrodes. Nanostructuring of the surface of the stimulating contacts of CI electrodes additionally resulted in a delayed increase in impedance showing that this modification has the potential for in vivo applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Tenhaven C.,Stiftung Tierarztliche Hochschule Hanover | Tipold A.,Stiftung Tierarztliche Hochschule Hanover | Fischer M.R.,Klinikum der LMU Munich | Ehlers J.P.,Stiftung Tierarztliche Hochschule Hanover
GMS Zeitschrift fur Medizinische Ausbildung | Year: 2013

Introduction: Informal and formal lifelong learning is essential at university and in the workplace. Apart from classical learning techniques, Web 2.0 tools can be used. It is controversial whether there is a so-called net generation amongst people under 30. Aims: To test the hypothesis that a net generation among students and young veterinarians exists. Methods: An online survey of students and veterinarians was conducted in the German-speaking countries which was advertised via online media and traditional print media. Results: 1780 people took part in the survey. Students and veterinarians have different usage patterns regarding social networks (91.9% vs. 69%) and IM (55.9% vs. 24.5%). All tools were predominantly used passively and in private, to a lesser extent also professionally and for studying. Outlook: The use of Web 2.0 tools is useful, however, teaching information and media skills, preparing codes of conduct for the internet and verification of user generated content is essential. © 2013 Tenhaven et al. Source

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