Grenoble, France
Grenoble, France

Stendhal University, Grenoble III is a French university located in the outskirts of Grenoble offering courses in foreign languages and cultures, ancient and modern literature, language and communication science. Having traditionally focused on training educators, it has more recently become known for preparing students for careers in journalism, communication and culture.Each year, the CUEF educates over 3,000 foreign students through various exchange programs in fields covering the entire spectrum of French studies.The current president is Lise Dumasy. Wikipedia.


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Xue K.-H.,Stendhal University | Blaise P.,CEA Grenoble | Fonseca L.R.C.,University of Campinas | Nishi Y.,Stanford University
Physical Review Letters | Year: 2013

Tetragonal semimetallic phases are predicted for Hf2O 3 and Zr2O3 using density functional theory. The structures belong to space group P4̄m2 and are more stable than their corundum counterparts. Many body corrections at first order confirm their semimetallic character. The carrier concentrations are very similar for both materials, and are estimated as 1.8×1021 cm-3 for both electrons and holes, allowing for electric conduction. This could serve as a basic explanation for the low resistance state of hafnia-based resistive random access memory. © 2013 American Physical Society.


Cadet J.,Stendhal University | Cadet J.,CEA Grenoble | Douki T.,Stendhal University
Journal of Investigative Dermatology | Year: 2011

Exposure of cells and human skin to UVA radiation oxidatively induces damage to DNA that consists mostly of 8-oxo-7,8-dihydroguanine (8-oxoGua), together with relatively minor amounts of oxidized pyrimidine bases and oligonucleotide strand breaks. Singlet oxygen generated by the type II photosensitization mechanism forms 8-oxoGua, with a small contribution by hydroxyl radicals. The mechanisms of UVA-mediated formation of DNA oxidation products indicate the absence of induction of double-strand breaks. © 2011 The Society for Investigative Dermatology.


Delangle P.,Stendhal University | Mintz E.,CNRS Chemistry and Biology of Metals Laboratory
Dalton Transactions | Year: 2012

Wilson's disease is an orphan disease due to copper homeostasis dysfunction. Mutations of the ATP7B gene induces an impaired functioning of a Cu-ATPase, impaired Cu detoxification in the liver and copper overload in the body. Indeed, even though copper is an essential element, which is used as cofactor by many enzymes playing vital roles, it becomes toxic when in excess as it promotes cytotoxic reactions leading to oxidative stress. In this perspective, human copper homeostasis is first described in order to explain the mechanisms promoting copper overload in Wilson's disease. We will see that the liver is the main organ for copper distribution and detoxification in the body. Nowadays this disease is treated life-long by systemic chelation therapy, which is not satisfactory in many cases. Therefore the design of more selective and efficient drugs is of great interest. A strategy to design more specific chelators to treat localized copper accumulation in the liver will then be presented. In particular we will show how bioinorganic chemistry may help in the design of such novel chelators by taking inspiration from the biological copper cell transporters. © 2012 The Royal Society of Chemistry.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2013-IRSES | Award Amount: 222.60K | Year: 2014

The programme brings into collaborative work four research teams (one from France, one from Italy, two from South Africa as third country), whose expertise is on multimodality in human interaction, language acquisition, gesture and cognition. It is grounded on past and present scientific collaboration on the development of narrative abilities in children. The main goal is to share methods, data and multimodal annotation tools for the study of language and gesture, as well as to cooperate at a high scientific level. It also includes the training of young researchers and the enhancement of new professional practices in the field of speech therapy and related fields. On the scientific level, the programme tests the validity of a gesture task to assess early lexical abilities in children of different countries, explores the cognitive aspect of representational gesture in early and late childhood, and investigates the effect of linguistic and cultural constraints on multimodal language production in comparing two Romance and two Bantu languages. These are key issues in the field of language and gesture studies; a field that has developed rapidly within the last ten years and which is now at the cutting edge of the research on human communication. The exchange programme will extend the expertise of each one of the four research units involved. The outcome of the exchange is the introduction of a new language assessment tool for young children in South Africa and France, and the training of young researchers to do psycholinguistics and research on gesture and multimodality in human interaction, in South Africa as well as in Europe. The exchange also aims at establishing a sustained collaboration with the third country partners in Johannesburg and Cape Town, and at reinforcing the cooperation between the two European partners in Rome and Grenoble.


Fries P.H.,Stendhal University | Belorizky E.,Joseph Fourier University
Journal of Chemical Physics | Year: 2010

We present a theoretical model for calculating the relaxivity of the water protons due to Gd3+ complexes trapped inside nanovesicles, which are permeable to water. The formalism is applied to the characterization of apoferritin systems [S. Aime, Angew. Chem., Int. Ed. 41, 1017 (2002); O. Vasalatiy, Contrast Media Mol. Imaging 1, 10 (2006)]. The very high relaxivity due to these systems is attributed to an increase of the local viscosity of the aqueous solution inside the vesicles and to an outer-sphere mechanism which largely dominates the inner-sphere contribution. We discuss how to tailor the dynamic parameters of the trapped complexes in order to optimize the relaxivity. More generally, the potential of relaxivity studies for investigating the local dynamics and residence time of exchangeable molecules in nanovesicles is pointed out. © 2010 American Institute of Physics.


Ghibaudo G.,Stendhal University
Solid-State Electronics | Year: 2012

The variability performance of JAM devices is studied owing to an analytical formula for V t variance and to 2D numerical simulation doping sensitivity analysis. Both approaches clearly indicate that JAM devices exhibit 2-5 times larger V t and drain current variability than in inversion mode Trigates. This suggests that the optimization of JAM transistors should carefully take into account this aspect in their technological design. © 2012 Elsevier Ltd. All rights reserved.


Fries P.H.,Stendhal University
Journal of Chemical Physics | Year: 2010

We present a two-particle Monte Carlo method for computing the outer-sphere (OS) dipolar time correlation function (DTCF) of the relative position of a nuclear spin I on a diamagnetic molecule MI with respect to a nuclear or electronic spin S on a molecule MS when both molecules are anisotropic and undergo translational and rotational diffusion. As a first application, we question the validity of the appealing interspin procedure [L. P. Hwang, Mol. Phys. 51, 1235 (1984); A. Borel, Chem. Eur. J. 7, 600 (2001)] based on the solutions of a Smoluchowski diffusion equation, which conserve the interspin radial distribution function in the course of time. We show that the true random spatial motion of the interspin vector obtained by simulation can be very different from that given by the Smoluchowski solutions and lead to notable retardation of the time decay of the OS-DTCF. Then, we explore the influence of the solvation properties of MS on the decay rate of the DTCF. When MS is significantly larger than MI, its rotation accelerates the decay only weakly, even if MI follows M S in its Brownian tumbling. By contrast, viscous solvation layers in OS pockets of MS can yield an important local slowdown of the relative translational diffusion of MI, leading to a decay retardation of the DTCF, which adds to that due to the shape anisotropy of MS. When MS is a Gd3+ -based contrast agent, this retardation leads to a notable increase of the OS contribution to relaxivity even at rather high imaging field. © 2010 American Institute of Physics.


Fries P.H.,Stendhal University
European Journal of Inorganic Chemistry | Year: 2012

In a molecular frame rigidly bound to the contrast agent, the instantaneous zero-field splitting (ZFS) Hamiltonian acting on the Gd 3+ electronic spin, S, has a constant mean value, named static ZFS (Hamiltonian). Expressed in the laboratory frame, the static ZFS has a random variation with time, which stems from the Brownian rotation of the complex and can be the source of a fast electronic spin relaxation that significantly quenches the relaxivity at low field. Except in a few cases, the static ZFS is too large and the Brownian rotation is too slow for the electronic relaxation to be described by Redfield analytical equations. Here, we present a formalism for simulating the quantum time correlation functions (TCFs) of the electronic spin operators, which properly account for relaxivity quenching by electronic relaxation. Though the formalism can be used at all field values, the interpretation of the high-field relaxivity with the help of simple justified analytical equations is recommended. The simulation procedure is illustrated by the case study of a model of the complex Gddtpa {[Gd 3+(dtpa)(H 2O)] 2- (dtpa 5- = diethylenetriamine pentaacetate)}. The numerical implementation of the simulation at several levels of parallel computing is examined. Simulated time correlation functions of the fluctuating intramolecular local dipolar field created by Gd 3+ in a Gddtpa-like complex giving rise to inner sphere relaxivity at 0 and 1.25 T. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu X.Q.,Stendhal University | Picart C.,Stendhal University
Advanced Materials | Year: 2016

The layer-by-layer (LbL) technique was introduced in the early 1990s. Since then, it has undergone a series of technological developments, making it possible to engineer various theranostic platforms, such as films and capsules, with precise control at the nanometer and micrometer scales. Recent progress in the applications of LbL assemblies in the field of cancer therapy, diagnosis, and fundamental biological study are highlighted here. The potential of LbL-based systems as drug carriers is discussed, especially with regard to the engineering of innovative stimuli-responsive systems, and their advantageous multifunctionality in the development of new therapeutic tools. Then, the diagnostic functions of LbL assemblies are illustrated for detection and capture of rare cancer cells. Finally, LbL-mimicking extracellular environments demonstrate the emerging potential for the study of cancer cell behavior in vitro. The advantages of LbL systems, important challenges that need to be overcome, and future perspectives in clinical practice are then highlighted. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


We propose an easily applicable method for investigating the pair distribution function of a lanthanide Ln 3 complex LnL (L ligand) with respect to any solvent or solute molecule A carrying observable nuclear spins. Let r be the distance of Ln 3 to the observed nuclear spin I. We derive a simple expression of the experimental value of the configurational average of 1r 6 in terms of longitudinal paramagnetic relaxation (rate) enhancements (PREs) of the spin I measured on a standard high-resolution NMR spectrometer and due to well-chosen concentrations of LnL complexes in which Ln 3 is a fast-relaxing paramagnetic lanthanide or the slowly-relaxing gadolinium Gd 3. The derivation is justified in the general case of a molecule A which is by turns in a bound state where it follows the complex and a free state where it moves independently. It rests on the expression of the underlying PRE theory in terms of the angle-dependent pair distribution function of LnL and A. The simplifications of this theory in the high-field regime and under the condition of fast exchange between bound and free states are carefully discussed. We also show that original information on the angle dependence of the molecular pair distribution function can be gained from the measured paramagnetic dipolar shifts induced by complexed fast-relaxing Ln 3 ions. The method is illustrated by the case study of the anionic Lnttha 3- Ln 3(ttha) 3- (ttha 6- triethylene tetraamine hexacetate) complex interacting with the biologically important tripeptide Arg-Gly-Asp (RGD) which carries peripheral ionic groups. The usefulness of an auxiliary reference outer sphere probe solute is emphasized. © 2012 American Institute of Physics.

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