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Zare N.,Shiraz University of Medical Sciences | Shahsavari S.,Shiraz University of Medical Sciences | Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Mehrabani D.,Shiraz University of Medical Sciences | Saberi-Firoozi M.,Tehran University of Medical Sciences
Pakistan Journal of Medical Sciences | Year: 2012

Objectives: To determine the migraine risk factors in Qashqai migrating nomads using an adjusted multiple correspondence analysis approach. Methodology: In summer 2006, 750 Qashqai migrating nomads aged 25 years or older in Fars Province, Southern Iran were enrolled using a multiple-stage cluster random sampling. A questionnaire consisting of demographic characteristics, lifestyle and migraine diagnosis was used for each subject. The association of each risk factor was assessed using an adjusted multiple correspondence analysis. Results: The prevalence of migraine was 18% in males and 28% in females. It was higher in overweight and obese subjects, those who consumed roasted foods, widows, female gender and in the age group of 35-50 years old. Conclusion: Multiple correspondence analyses were suitable choices to determine detailed results of complex categorical data in migraine risk factors.


Sarhadi S.,Research Center for Traditional Medicine and History of Medicine | Safari A.,Research Center for Traditional Medicine and History of Medicine | Borhani-Haghighi A.,Stem Cell and Transgenic Technology Research Center | Borhani-Haghighi A.,Shiraz University of Medical Sciences
International Journal of Rheumatic Diseases | Year: 2012

Aim: To investigate MRI findings that may predict unfavorable outcomes in the patients with neuro-Behçet's disease. Subjects and Methods: All consecutive patients referred from 2002 to 2009 to the Behçet Clinic at Nemazee Hospital, Shiraz, Iran, who fulfilled International Study Group criteria for Behçet's disease and diagnosed as having neuro-Behçet's disease, were enrolled into this study. Characteristics of initial brain MRI were studied in patients with different courses of neuro-Behçet's disease. Results: Initial MRIs of 58 patients (31 women) with a mean ± SD age of 38.9 ± 9.7 years were reviewed. Forty-nine (84%) patients had parenchymal and nine (16%) had non-parenchymal neuro-Behçet's disease. Of those patients with parenchymal neuro-Behçet's disease, 15 (31%) had monophasic, 13 (27%) polyphasic and 10 (20%) progressive courses; 11 (22%) had only headache attributed to Behçet's disease. The most common sites of involvement in patients with parenchymal neuro-Behçet's disease were periventricular and superficial cerebral white matter, midbrain and pons, respectively. Of those with parenchymal involvement, 12 (24%) had extension of lesions, seven (14%) had contrast enhancement, 12 (24%) had black holes and five (10%) had brainstem atrophy. Patients with a progressive course had a significantly (P = 0.017; OR = 18, 95% CI: 1.7-19.1) higher rate of brainstem atrophy than those with a non-progressive course (monophasic or polyphasic). Conclusion: Presence of brainstem atrophy in the initial MRIs may predict a progressive course in patients with neuro-Behçet's disease. © 2012 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.


Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Asgari Q.,Stem Cell and Transgenic Technology Research Center | Owji S.M.,Shiraz University of Medical Sciences
Pakistan Journal of Medical Sciences | Year: 2011

Objectives: This study identifies the infected rodent hosts to Leishmania major in Estahban town, southern Iran during 2004-2005. Methodology: The rodents were caught alive from April 2004 to April 2005 in Estahban town, south of Iran and examined for any skin lesion. An impression was provided from the tissues of feet, tail, ears and any patent lesion, stained with Giemsa and studied microscopically for the presence of amastigotes. All samplings were cultured at 25°C in rabbit blood agar and considered negative if no promastigotes were visible during a two months period. The parasites from any positive culture were cryopreserved in liquid nitrogen pending their identification in PCR and isoenzyme electrophoresis. The femoral bones were histologically and ultrastrucrurally studied. Results: Among 13 captured rodents, 8 were Tatera indica (5 male and 3 female Indian gerbils) and 5 were Rattus rattus (3 males and 2 females). Just one female T. indica was smear-positive for amastigotes in Mohmmad Abad village. This rodent was also found culture positive for leishmanial infection which was confirmed by PCR and enzyme electrophoresis. At histological and ultrastructural levels, many clusters of amastigotes were noticed in the foamy macrophages of the femoral bone bone marrow. Conclusion: T. indica was found for the first time in the area and can be one of the rodents to be a potential reservoir host of L. major. It was also shown that femoral bone marrow was the tissue of choice to confirm the presence of macrophages containing the amastigote form of the parasite.


Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Hosseini S.V.,Laparascopy Research Center | Rezaianzadeh A.,Gastroenterohepatology Research Center | Amini M.,Laparascopy Research Center | And 2 more authors.
Journal of Research in Medical Sciences | Year: 2013

Background: Worldwide, cancer of stomach is still the fourth common cancer and the second cause of mortality among all cancers affecting annually 870, 000 subjects. This study aims to determine the frequency and the characteristics of gastric cancer in southern Iran. Materials and Methods: 10, 800 of all cancers registered in Fars Hospital-based Cancer Registry were surveyed among which 574 cases were gastric cancer in both genders and all age groups. From January 2002 to December 2007, all hospital-based data were recorded according to International Classification of Disease for Oncology (ICD-O) and registered cases included all invasive cancers in ICD-10 categories of C-00 to C-80 and all duplicate cases were eliminated. Results: Among all registered cancers, there were 574 cases of gastric cancer including 69.3% males. The mean age of patients was 58.1 ± 14.8 years, 25.4% with a history of in their first relatives and most of them were smokers (50.9%) and from low socioeconomic class (45.5%). Metastasis was visible in 182 patients and majority of them underwent surgery (64.3%). The majority of gastric cancer patients were older than 50 years, smokers, low socioeconomic class, and female in favor of adenocarcinoma. Conclusion: Our results showed that in our area, treatment programs and health plans should focus on men, patients older than 50 years and with adenocarcinoma, smokers, and those in a low income level.


Masoumi S.J.,Shiraz University of Medical Sciences | Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Moradi F.,Shiraz Geriatric Research Center | Zare N.,Shiraz University of Medical Sciences | And 2 more authors.
Pakistan Journal of Medical Sciences | Year: 2015

Objectives: To determine the prevalence of dyspepsia and its correlation with quality of life in Fars Qashqai Turkish migrating nomads from Southern Iran. Methods: During 2010 we enrolled 397 Qashqai migrating nomads from Southern Iran who were 25 years of age or older. Participants completed a questionnaire that consisted of demographic factors, lifestyle data, gastrointestinal symptoms, and the Short-Form 36 Health Survey (SF-36) questionnaire. Results: There was a 48% prevalence of dyspepsia symptoms among participants. The prevalence was higher among females, those less than 35 years of age, married participants, and those with a low body mass index (BMI). The correlation between dyspepsia and quality of life was significant. Dyspeptic patients were classified into ulcer-like (27.9%), dysmotility-like (26.2%), and unspecified (45.9%) groups. A significant correlation existed between dyspepsia symptoms and consumption of dairy products, drinking water and tea before and after meals, smoking, dysphagia, reflux, heartburn, and use of non-steroid antiinflammatory drugs and acetaminophen. Conclusion: The high prevalence of dyspepsia in Qashqai nomads necessitates educational health programs for the migrating tribes in order to decrease prevalence of this disease. © 2015, Pak J Med Sci. All Rights Reserved.


Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Shamsdin S.A.,Shiraz University of Medical Sciences | Dehghan A.,Shiraz University of Medical Sciences | Safarpour A.,Shiraz University of Medical Sciences
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: Colon cancer (CRC) is perhaps the second most common cause of cancer mortality. This study determined the clinical significance of serum vascular endothelial growth factor (VEGF) and serum complement 3a (C3a) levels in patients with CRC in Fars province, southern Iran. Materials and Methods: Between June 2010 and June 2012, 110 patients with CRC of both genders and different age groups were divided into 3 groups. Group A included patients who had just undergone surgery; Group B had undergone chemotherapy after surgery; and Group C had undergone chemotherapy and radiotherapy after surgery. Twenty one healthy subjects with normal colonoscopy were considered as a control group. ELISA was undertaken to determine VEGF and C3a levels before and after treatment measures. Results: The mean age of patients was 53.9 ± 14.1 years. Considering VEGF level, a significant decrease was visible after treatment measures in groups A and B, but not Group C. For VEGF level, the difference was not statistically significant between two genders and various age groups before and after treatment. No significant difference was found for VEGF level between patients and normal group before any treatment. Regarding C3a levels in 101 subjects, they significantly decreased after treatment measures. Before and after treatment, the difference was statistically significant between two genders, but was not statistically significant among various age groups. Conclusions: As VEGF and C3a levels were significantly lower in patients after treatment, these may be beneficial markers in assessment of CRC therapy especially in early stages.


PubMed | Stem Cell and Transgenic Technology Research Center
Type: Journal Article | Journal: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences | Year: 2013

Worldwide, cancer of stomach is still the fourth common cancer and the second cause of mortality among all cancers affecting annually 870,000 subjects. This study aims to determine the frequency and the characteristics of gastric cancer in southern Iran.10,800 of all cancers registered in Fars Hospital-based Cancer Registry were surveyed among which 574 cases were gastric cancer in both genders and all age groups. From January 2002 to December 2007, all hospital-based data were recorded according to International Classification of Disease for Oncology (ICD-O) and registered cases included all invasive cancers in ICD-10 categories of C-00 to C-80 and all duplicate cases were eliminated.Among all registered cancers, there were 574 cases of gastric cancer including 69.3% males. The mean age of patients was 58.1 14.8 years, 25.4% with a history of in their first relatives and most of them were smokers (50.9%) and from low socioeconomic class (45.5%). Metastasis was visible in 182 patients and majority of them underwent surgery (64.3%). The majority of gastric cancer patients were older than 50 years, smokers, low socioeconomic class, and female in favor of adenocarcinoma.Our results showed that in our area, treatment programs and health plans should focus on men, patients older than 50 years and with adenocarcinoma, smokers, and those in a low income level.

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