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Sarhadi S.,Research Center for Traditional Medicine and History of Medicine | Safari A.,Research Center for Traditional Medicine and History of Medicine | Borhani-Haghighi A.,Stem Cell and Transgenic Technology Research Center | Borhani-Haghighi A.,Shiraz University of Medical Sciences
International Journal of Rheumatic Diseases

Aim: To investigate MRI findings that may predict unfavorable outcomes in the patients with neuro-Behçet's disease. Subjects and Methods: All consecutive patients referred from 2002 to 2009 to the Behçet Clinic at Nemazee Hospital, Shiraz, Iran, who fulfilled International Study Group criteria for Behçet's disease and diagnosed as having neuro-Behçet's disease, were enrolled into this study. Characteristics of initial brain MRI were studied in patients with different courses of neuro-Behçet's disease. Results: Initial MRIs of 58 patients (31 women) with a mean ± SD age of 38.9 ± 9.7 years were reviewed. Forty-nine (84%) patients had parenchymal and nine (16%) had non-parenchymal neuro-Behçet's disease. Of those patients with parenchymal neuro-Behçet's disease, 15 (31%) had monophasic, 13 (27%) polyphasic and 10 (20%) progressive courses; 11 (22%) had only headache attributed to Behçet's disease. The most common sites of involvement in patients with parenchymal neuro-Behçet's disease were periventricular and superficial cerebral white matter, midbrain and pons, respectively. Of those with parenchymal involvement, 12 (24%) had extension of lesions, seven (14%) had contrast enhancement, 12 (24%) had black holes and five (10%) had brainstem atrophy. Patients with a progressive course had a significantly (P = 0.017; OR = 18, 95% CI: 1.7-19.1) higher rate of brainstem atrophy than those with a non-progressive course (monophasic or polyphasic). Conclusion: Presence of brainstem atrophy in the initial MRIs may predict a progressive course in patients with neuro-Behçet's disease. © 2012 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd. Source

Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Hosseini S.V.,Laparascopy Research Center | Rezaianzadeh A.,Gastroenterohepatology Research Center | Amini M.,Laparascopy Research Center | And 2 more authors.
Journal of Research in Medical Sciences

Background: Worldwide, cancer of stomach is still the fourth common cancer and the second cause of mortality among all cancers affecting annually 870, 000 subjects. This study aims to determine the frequency and the characteristics of gastric cancer in southern Iran. Materials and Methods: 10, 800 of all cancers registered in Fars Hospital-based Cancer Registry were surveyed among which 574 cases were gastric cancer in both genders and all age groups. From January 2002 to December 2007, all hospital-based data were recorded according to International Classification of Disease for Oncology (ICD-O) and registered cases included all invasive cancers in ICD-10 categories of C-00 to C-80 and all duplicate cases were eliminated. Results: Among all registered cancers, there were 574 cases of gastric cancer including 69.3% males. The mean age of patients was 58.1 ± 14.8 years, 25.4% with a history of in their first relatives and most of them were smokers (50.9%) and from low socioeconomic class (45.5%). Metastasis was visible in 182 patients and majority of them underwent surgery (64.3%). The majority of gastric cancer patients were older than 50 years, smokers, low socioeconomic class, and female in favor of adenocarcinoma. Conclusion: Our results showed that in our area, treatment programs and health plans should focus on men, patients older than 50 years and with adenocarcinoma, smokers, and those in a low income level. Source

Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Asgari Q.,Stem Cell and Transgenic Technology Research Center | Owji S.M.,Shiraz University of Medical Sciences
Pakistan Journal of Medical Sciences

Objectives: This study identifies the infected rodent hosts to Leishmania major in Estahban town, southern Iran during 2004-2005. Methodology: The rodents were caught alive from April 2004 to April 2005 in Estahban town, south of Iran and examined for any skin lesion. An impression was provided from the tissues of feet, tail, ears and any patent lesion, stained with Giemsa and studied microscopically for the presence of amastigotes. All samplings were cultured at 25°C in rabbit blood agar and considered negative if no promastigotes were visible during a two months period. The parasites from any positive culture were cryopreserved in liquid nitrogen pending their identification in PCR and isoenzyme electrophoresis. The femoral bones were histologically and ultrastrucrurally studied. Results: Among 13 captured rodents, 8 were Tatera indica (5 male and 3 female Indian gerbils) and 5 were Rattus rattus (3 males and 2 females). Just one female T. indica was smear-positive for amastigotes in Mohmmad Abad village. This rodent was also found culture positive for leishmanial infection which was confirmed by PCR and enzyme electrophoresis. At histological and ultrastructural levels, many clusters of amastigotes were noticed in the foamy macrophages of the femoral bone bone marrow. Conclusion: T. indica was found for the first time in the area and can be one of the rodents to be a potential reservoir host of L. major. It was also shown that femoral bone marrow was the tissue of choice to confirm the presence of macrophages containing the amastigote form of the parasite. Source

Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Motazedian M.H.,Shiraz University of Medical Sciences | Hatam G.R.,Shiraz University of Medical Sciences | Asgari Q.,Shiraz University of Medical Sciences | And 2 more authors.
Asian Journal of Animal and Veterinary Advances

This study was undertaken to identify rodents infected with Leishmania in Fasa town, Fars Province, Southern Iran. From April 2004 to April 2005, a total of 17 rodents were collected in live traps in the area. Microscopical examination of stained tissue smears and the culture of tissue samples, PCR, isoenzyme electrophoresis and morphological review were used for detection of the parasite. The captured rodents were 10 Rathus rathus and 7 Tatera indica. One male T. indica was infected with L. major in Zahedshahr District of Fasa town. In histological and ultrastructural studies, numerous clusters of amastigotes were seen in the foamy macrophages of bone marrow of the femoral bone. We can conclude that T. indica is one of the rodents that may be a potential reservoir host of L. major in the region and femoral bone marrow is morphologically the tissue of choice to confirm the presence of macrophages containing the amastigote form of the parasite. © 2011 Academic Journals Inc. Source

Masoumi S.J.,Shiraz University of Medical Sciences | Mehrabani D.,Stem Cell and Transgenic Technology Research Center | Moradi F.,Shiraz Geriatric Research Center | Zare N.,Shiraz University of Medical Sciences | And 2 more authors.
Pakistan Journal of Medical Sciences

Objectives: To determine the prevalence of dyspepsia and its correlation with quality of life in Fars Qashqai Turkish migrating nomads from Southern Iran. Methods: During 2010 we enrolled 397 Qashqai migrating nomads from Southern Iran who were 25 years of age or older. Participants completed a questionnaire that consisted of demographic factors, lifestyle data, gastrointestinal symptoms, and the Short-Form 36 Health Survey (SF-36) questionnaire. Results: There was a 48% prevalence of dyspepsia symptoms among participants. The prevalence was higher among females, those less than 35 years of age, married participants, and those with a low body mass index (BMI). The correlation between dyspepsia and quality of life was significant. Dyspeptic patients were classified into ulcer-like (27.9%), dysmotility-like (26.2%), and unspecified (45.9%) groups. A significant correlation existed between dyspepsia symptoms and consumption of dairy products, drinking water and tea before and after meals, smoking, dysphagia, reflux, heartburn, and use of non-steroid antiinflammatory drugs and acetaminophen. Conclusion: The high prevalence of dyspepsia in Qashqai nomads necessitates educational health programs for the migrating tribes in order to decrease prevalence of this disease. © 2015, Pak J Med Sci. All Rights Reserved. Source

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