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Ananworanich J.,Red Cross | Ananworanich J.,Chulalongkorn University | Ananworanich J.,University of New South Wales | Bunupuradah T.,Red Cross | And 144 more authors.
AIDS Research and Therapy | Year: 2014

Background: This study assesses the relationships between lymphocyte and monocyte subsets and intelligence quotient (IQ) scores in antiretroviral therapy (ART)-naive, HIV-infected Thai children without advanced HIV disease.Findings: Sixty-seven ART-naive Thai children with CD4 between 15-24% underwent cognitive testing by Weschler intelligence scale and had 13 cell subsets performed by flow cytometry including naive, memory and activated subsets of CD4+ and CD8+ T cells, activated and perivascular monocytes and B cells. Regression modelling with log10 cell count and cell percentage transformation was performed.Median age (IQR) was 9 (7-10) years, 33% were male, CDC stages N:A:B were 1:67:31%, median CD4% and count (IQR) were 21 (18-24)%, 597 (424-801) cells/mm3 and HIV RNA (IQR) was 4.6 (4.1-4.9) log10 copies/ml. Most (82%) lived at home, 45% had a biological parent as their primary caregiver, and 26 (49%) had low family income. The mean (SD) scores were 75 (13) for full scale IQ (FIQ), 73 (12) for verbal IQ (VIQ) and 80 (14) for performance IQ (PIQ). Adjusted multivariate regression analysis showed significant negative associations between B cell counts and FIQ, VIQ and PIQ (p < 0.01 for all); similar associations were found for B cell percentages (p < 0.05 for all).Conclusions: High B cell counts and percentages were strongly associated with poorer FIQ, VIQ and PIQ scores. Prospective, long-term assessment of cell subsets and determination of relevant B cell subpopulations could help further elucidate associations between lymphocyte subsets and neurocognitive development. © 2014 Ananworanich et al.; licensee BioMed Central Ltd.


Lambert S.R.,Emory University | Buckley E.G.,Duke University | Drews-Botsch C.,Emory University | DuBois L.,Emory University | And 72 more authors.
Archives of Ophthalmology | Year: 2010

Objective: To compare the use of contact lenses and intraocular lenses (IOLs) for the optical correction of unilateral aphakia during infancy. Methods: In a randomized, multicenter (12 sites) clinical trial, 114 infants with unilateral congenital cataracts were assigned to undergo cataract surgery with or without IOL implantation. Children randomized to IOL treatment had their residual refractive error corrected with spectacles. Children randomized to no IOL treatment had their aphakia treated with a contact lens. Main Outcome Measures: Grating acuity at 12 months of age and HOTV visual acuity at 41/2 years of age. Application to Clinical Practice: This study should determine whether either treatment for an infant with a visually significant unilateral congenital cataract results in a better visual outcome. Results: Enrollment began December 23, 2004, and was completed January 16, 2009. The median age at the time of cataract surgery was 1.8 months. Fifty patients were 4 to 6 weeksofageatthetimeofenrollment;32,7weeksto3months ofage;andtheremaining32, morethan3tolessthan7months of age. Fifty-seven children were randomized to each treatment group. Eyes with cataracts had shorter axial lengths and steeper corneas on average than the fellow eyes. Conclusions: The optimal optical treatment of aphakia in infants is unknown. However, the Infant Aphakia Treatment Study was designed to provide empirical evidence of whether optical treatment with an IOL or a contact lens after unilateral cataract surgery during infancy is associated with a better visual outcome. Trial Registration: clinicaltrials.gov Identifier: NCT00212134. ©2010 American Medical Association. All rights reserved.


Suarez-Garcia I.,Infanta Sofia Hospital | Sobrino-Vegas P.,National Epidemiology Center | Tejada A.,Ramon y Cajal Hospital | Viciana P.,Virgen del Rocio Hospital | And 28 more authors.
HIV Medicine | Year: 2014

Objectives: The aim of the study was to assess the adequacy of initial antiretroviral therapy (ART), in terms of its timing and the choice of regimens, according to the Spanish national treatment guidelines [Spanish AIDS Study Group-National Plan for AIDS (GeSIDA-PNS) Guidelines] for treatment-naïve HIV-infected patients. Methods: A prospective cohort study of HIV-positive ART-naïve subjects attending 27 centres in Spain from 2004 to 2010 was carried out. Regimens were classified as recommended, alternative or nonrecommended according to the guidelines. Delayed start of treatment was defined as starting treatment later than 12 months after the patient had fulfilled the treatment criteria. Multivariate logistic and Cox regression analyses were performed. Results: A total of 6225 ART-naïve patients were included in the study. Of 4516 patients who started treatment, 91.5% started with a recommended or alternative treatment. The use of a nonrecommended treatment was associated with a CD4 count>500 cells/μL [odds ratio (OR) 2.03; 95% confidence interval (CI) 1.14-3.59], hepatitis B (OR 2.23; 95% CI 1.50-3.33), treatment in a hospital with <500 beds, and starting treatment in the years 2004-2006. Fourteen per cent of the patients had a delayed initiation of treatment. Delayed initiation of treatment was more likely in injecting drug users, patients with hepatitis C, patients with higher CD4 counts and during the years 2004-2006, and it was less likely in patients with viral loads>5 log HIV-1 RNA copies/ml. The use of a nonrecommended regimen was significantly associated with mortality [hazard ratio (HR) 1.61; 95% CI 1.03-2.52; P=0.035] and lack of virological response. Conclusions: Compliance with the recommendations of Spanish national guidelines was high with respect to the timing and choice of initial ART. The use of nonrecommended regimens was associated with a lack of virological response and higher mortality. © 2013 British HIV Association.


PubMed | Steering Committee, The River Project, Lamont Doherty Earth Observatory and Columbia University
Type: | Journal: The Science of the total environment | Year: 2016

To protect recreational water users from waterborne pathogen exposure, it is crucial that waterways are monitored for the presence of harmful bacteria. In NYC, a citizen science campaign is monitoring waterways impacted by inputs of storm water and untreated sewage during periods of rainfall. However, the spatial and temporal scales over which the monitoring program can sample are constrained by cost and time, thus hindering the construction of databases that benefit both scientists and citizens. In this study, we first illustrate the scientific value of a citizen scientist monitoring campaign by using the data collected through the campaign to characterize the seasonal variability of sampled bacterial concentration as well as its response to antecedent rainfall. Second, we examine the efficacy of the HyServe Compact Dry ETC method, a lower cost and time-efficient alternative to the EPA-approved IDEXX Enterolert method for fecal indicator monitoring, through a paired sample comparison of IDEXX and HyServe (total of 424 paired samples). The HyServe and IDEXX methods return the same result for over 80% of the samples with regard to whether a water sample is above or below the EPAs recreational water quality criteria for a single sample of 110 enterococci per 100mL. The HyServe method classified as unsafe 90% of the 119 water samples that were classified as having unsafe enterococci concentrations by the more established IDEXX method. This study seeks to encourage other scientists to engage with citizen scientist communities and to also pursue the development of cost- and time-efficient methodologies to sample environmental variables that are not easily collected or analyzed in an automated manner.


One of New Jersey’s Top Orthopedic Spine Surgeons Talks about the Latest Trends. Morristown, NJ, December 23, 2016 --( He is no stranger to innovation. He was the first orthopedic spine surgeon in New Jersey to use SYNTHESIS Cervical Total Disc Replacement and an early adopter of O-Arm Surgical Imaging System, which provides real-time, intraoperative imaging of a patient's anatomy with high quality images to make surgery safer. In each case there was compelling data and published reports with favorable results about these innovations to support their usage, and they made sense. This is part of the methodical process he uses any time he adopts a new technique or uses a new instrument for surgery. As a spine surgeon with more than 15 years of experience in all disorders of the spine, he doesn’t jump on the bandwagons of trends. By using methods that he’s used to perform countless surgeries, he’s saved lives and restored patients’ quality of life, whether it be chronic back pain or life-changing-or-threatening trauma. “There is no epiphany on how to treat back pain,” Richard Nachwalter, M.D., said. “Doctors know the most effective way to perform which procedure for which ailment based on a history of efficacy and safety. At Atlantic Spine Specialists, we always stay updated on what’s happening in orthopedic spine surgery. We only use gold standards of surgery, so we adopt a new technique once there is sufficient evidence that proves its effectiveness and safety.” Richard Nachwalter, M.D., served as the first chairman of the Spine New Technology Committee at Atlantic Health. He also serves on the Spine Steering committee and served on the Orthopedic advisory committee. He has recently been appointed to the Operating Room Committee at Morristown Medical Center. As a member of Atlantic Spine Specialists, he [and partner Carl Giordano, M.D.] utilize minimally invasive techniques, microscopic surgical techniques, and traditional surgery as well. For more information about Richard Nachwalter, M.D., you can visit http://atlanticspinespecialists.com/meet-richard-nachwalter-md/. About Atlantic Spine Specialists Atlantic Spine Specialists features board-certified, fellowship-trained spine surgeons. Located in Morristown, NJ, with a satellite office in Westfield, NJ; Atlantic Spine Specialists perform their procedures in Morristown Medical Center, a spine center of excellence. This facility is one of the few to earn this distinction from the Joint Commission on Accreditation of Healthcare Organizations (JCAHO). For more information about Atlantic Spine Specialists, you can visit their website at http://atlanticspinespecialists.com/ or call 973-971-3500. About GWP Inc GWP Inc., founded in 1991, is a full-service advertising agency in the heart of Montclair, NJ with a focus in Rebranding, Rebuilding and Revitalizing businesses. Among our in-house capabilities, are online and traditional media planning and buying, video production, online marketing, TV, radio and print creative and production. GWP is a boutique agency with five divisions, working independently and/or in concert to deliver strategically sound, creatively crafted, targeted campaigns. For more information about GWP Inc., visit their website at http://gwpinc.com/ or call 973-746-0500. Morristown, NJ, December 23, 2016 --( PR.com )-- Richard Nachwalter, M.D., a leading orthopedic spine surgeon and part of Atlantic Spine Specialists in Morristown, NJ; appreciates innovation, but when it comes to innovation for surgery, it’s not about being the first.He is no stranger to innovation. He was the first orthopedic spine surgeon in New Jersey to use SYNTHESIS Cervical Total Disc Replacement and an early adopter of O-Arm Surgical Imaging System, which provides real-time, intraoperative imaging of a patient's anatomy with high quality images to make surgery safer. In each case there was compelling data and published reports with favorable results about these innovations to support their usage, and they made sense. This is part of the methodical process he uses any time he adopts a new technique or uses a new instrument for surgery.As a spine surgeon with more than 15 years of experience in all disorders of the spine, he doesn’t jump on the bandwagons of trends. By using methods that he’s used to perform countless surgeries, he’s saved lives and restored patients’ quality of life, whether it be chronic back pain or life-changing-or-threatening trauma.“There is no epiphany on how to treat back pain,” Richard Nachwalter, M.D., said. “Doctors know the most effective way to perform which procedure for which ailment based on a history of efficacy and safety. At Atlantic Spine Specialists, we always stay updated on what’s happening in orthopedic spine surgery. We only use gold standards of surgery, so we adopt a new technique once there is sufficient evidence that proves its effectiveness and safety.”Richard Nachwalter, M.D., served as the first chairman of the Spine New Technology Committee at Atlantic Health. He also serves on the Spine Steering committee and served on the Orthopedic advisory committee. He has recently been appointed to the Operating Room Committee at Morristown Medical Center. As a member of Atlantic Spine Specialists, he [and partner Carl Giordano, M.D.] utilize minimally invasive techniques, microscopic surgical techniques, and traditional surgery as well. For more information about Richard Nachwalter, M.D., you can visit http://atlanticspinespecialists.com/meet-richard-nachwalter-md/.About Atlantic Spine SpecialistsAtlantic Spine Specialists features board-certified, fellowship-trained spine surgeons. Located in Morristown, NJ, with a satellite office in Westfield, NJ; Atlantic Spine Specialists perform their procedures in Morristown Medical Center, a spine center of excellence. This facility is one of the few to earn this distinction from the Joint Commission on Accreditation of Healthcare Organizations (JCAHO). For more information about Atlantic Spine Specialists, you can visit their website at http://atlanticspinespecialists.com/ or call 973-971-3500.About GWP IncGWP Inc., founded in 1991, is a full-service advertising agency in the heart of Montclair, NJ with a focus in Rebranding, Rebuilding and Revitalizing businesses. Among our in-house capabilities, are online and traditional media planning and buying, video production, online marketing, TV, radio and print creative and production. GWP is a boutique agency with five divisions, working independently and/or in concert to deliver strategically sound, creatively crafted, targeted campaigns. For more information about GWP Inc., visit their website at http://gwpinc.com/ or call 973-746-0500. Click here to view the list of recent Press Releases from Atlantic Spine Specialists

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