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Atlanta, GA, United States

Fonjungo P.N.,STD and TB Laboratory Research | Fonjungo P.N.,Centers for Disease Control and Prevention | Kalish M.L.,STD and TB Laboratory Research | Schaefer A.,STD and TB Laboratory Research | And 6 more authors.
PLoS ONE | Year: 2014

We analyzed genetic diversity and phylogenetic relationships among 124 HIV-1 and 19 HIV-2 strains in sera collected in 1986 from patients of the state hospital in Ouagadougou, Burkina Faso. Phylogenetic analysis of the HIV-1 env gp41 region of 65 sequences characterized 37 (56.9%) as CRF06-cpx strains, 25 (38.5%) as CRF02-AG, 2 (3.1%) as CRF09-cpx, and 1 (1.5%) as subtype A. Similarly, phylogenetic analysis of the protease (PR) gene region of 73 sequences identified 52 (71.2%) as CRF06-cpx, 15 (20.5%) as CRF02-AG, 5 (6.8%) as subtype A, and 1 (1.4%) was a unique strain that clustered along the B/D lineage but basal to the node connecting the two lineages. HIV-2 PR or integrase (INT) groups A (n = 17 [89.5%]) and B (n = 2 [10.5%]) were found in both monotypic (n = 11) and heterotypic HIV-1/HIV-2 (n = 8) infections, with few HIV-2 group B infections. Based on limited available sampling, evidence suggests two recombinant viruses, CRF06-cpx and CRF02-AG, appear to have driven the beginning of the mid-1980s HIV-1 epidemic in Burkina Faso. Source

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