Stavropol State Medical Academy

Stavropol’, Russia

Stavropol State Medical Academy

Stavropol’, Russia
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Blagodatskikh K.A.,State Research Center Gosenetika | Agapkina Y.V.,State Research Center Gosenetika | Nikitin A.G.,State Research Center Gosenetika | Brovkin A.N.,State Research Center Gosenetika | And 25 more authors.
Molecular Biology | Year: 2010

Association between the rates of poor outcomes in the patient cohort with acute coronary syndrome and polymorphisms G(-174)C in the IL6 gene and G(-1082)A in the IL10 gene were determined. In total, 1145 patients hospitalized for coronary artery disease to cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don were examined. The mean observation period was 9.10 ± 5.03 months (maximal, 18 months). Analysis of the survival of the patients with acute coronary syndrome that carried allele A has demonstrated that the presence of IL10 gene polymorphism G(-1082)A is associated with more frequent poor outcomes as compared with GG genotype. The survival time to endpoint for the carriers of GA and AA genotypes was 11.68 ± 0.67 months versus 12.69 ± 0.65 months for the carriers of GG genotype in IL10 gene (χ2 = 4.13, p = 0.042). As for the IL6 gene polymorphism G(-174)C, survival rate analysis did not detect any significant association with the risk for poor outcome. However, joint analysis of these polymorphisms in both genes has demonstrated that characteristic of the patients with acute coronary syndrome that carry GG genotype of IL6 gene and GA and AA genotypes of IL10 is a higher rate of poor outcomes (time to endpoint, 11.01 ± 1.24 months) as compared with the carriers of IL6 gene CC and CG genotypes and IL10 gene GG genotype (time to endpoint, 13.28 ± 0.83 months (ξ2 = 10.23, p = 0.017). These data suggest that the genes IL6 and IL10, whose products are involved in the control of inflammatory response, play an important role by increasing the probability of poor outcomes in the patients with acute coronary syndrome. © 2010 Pleiades Publishing, Ltd.

Pushkov A.A.,State Research Center Gosgenetika | Blagodatskikh K.A.,State Research Center Gosgenetika | Nikitin A.G.,State Research Center Gosgenetika | Agapkina Y.V.,State Research Center Gosgenetika | And 27 more authors.
Russian Journal of Genetics | Year: 2011

The polymorphic markers Ala455Val of the THBD gene and Arg353Gln of the F7 gene were tested for association with the frequency of unfavorable outcomes in patients with a history of acute ischemic heart disease. The study involved 1145 patients hospitalized in cardiology clinics of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don because of acute ischemic heart disease. The patients were followed up for up to 62.5 months. None of the markers displayed a significant association with the time to an endpoint. The patients were then grouped by sex. In females, the frequency of unfavorable outcomes (fatal or nonfatal myocardial infarction and fatal or nonfatal stroke) was higher in carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and carriers of genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene, but the difference was not statistically significant. Such an increase in frequency was not observed in males. To study the combined effect of the polymorphic markers of the THBD and F7 genes, the course of ischemic heart disease was compared for two female subgroups. One included carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene; the other subgroup included carriers of genotype Ala/Ala of the Ala455Val polymorphic marker of the THBD gene and allele Gln of the Arg353Gln polymorphic marker of the F7 gene. The frequency of unfavorable outcomes in the first subgroup was higher than in the second one. The time to an endpoin was 40.5 months (95% confidence interval (CI) 33.5-47.6) in the first subgroup and 51.6 months (95% CI 45.0-58.1) in the second subgroup (χ 2 = 4.15, P = 0.042). The results made it possible to assume that the F7 and THBD genes play an important role in genetic predisposition to unfavorable outcomes in patients with a history of acute ischemic heart disease. © 2011 Pleiades Publishing, Inc.

Agapkina Y.V.,State Research Center Gos Genetika | Nikitin A.G.,State Research Center Gos Genetika | Brovkin A.N.,State Research Center Gos Genetika | Pushkov A.A.,State Research Center Gos Genetika | And 24 more authors.
Molecular Biology | Year: 2010

Associations of polymorphisms of genes FGB G(-455)A and PROC C(-1654)T with the frequency of poor outcomes in patients with the history of acute coronary syndrome (ACS) were studied in the Russian population. A total of 1145 patients admitted to cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don with ischemic heart disease exacerbation were examined. The mean follow-up time was 1.14 ± 0.33 years, and the maximum follow-up time was 3.2 years. The risk of poor outcome did not depend on the carriership of genotypes of the polymorphic G(-455)A marker in the FGB gene. However, the PROC C(-1654)T polymorphism patients with ACS history and allele T of the PROC gene had a poor outcome more often than patients homozygous for allele C. The survival time to the endpoint for carriers of the TT and CT genotypes of the PROC gene was 2.19 ± 0.18 years vs. 2.46 ± 0.16 years for carriers of the CC genotype. On the base of these results it is suggested that hemostasis-related genes play an important role in early failures in patients with ACS history. © 2010 Pleiades Publishing, Ltd.

Gusenitsa S.G.,Stavropol State Medical Academy | Barachevsky Yu.E.,Northern State University | Ivanov A.O.,Mechnikov Saint Petersburg State Medical Academy | Groshilin S.M.,Rostov State Medical University | Yurieva M.Yu.,Northern State University
Human Ecology | Year: 2012

The goal of the work was to reason complex applications of contrast temperature effects for promotion of physical efficiency in healthy men. 35 healthy volunteers with low physical endurance were examined. For restoration of their physical endurance, we used cyclic infrared and cryothermic effects. The interactive physical endurance was estimated with the use of the increasing veloergometry test. It has been determined that after the five-day course of infrared treatment, the low spare capacities and physical endurance were recovered. The five-day course of aerocryothermic treatment was accompanied by long-time adaptation shifts in the organisms. This nonmedical physiotherapeutic method allows to protract our positive treatment effects.

Shebzukhova I.G.,Kabardino-Balkarian State University | Arefieva L.P.,Stavropol State Medical Academy | Khokonov Kh.B.,Kabardino-Balkarian State University
Bulletin of the Russian Academy of Sciences: Physics | Year: 2012

Dimensional and orientational dependences of the surface energy of thin cadmium films are com- puted by means of electron-statistical theory. The surface energy of different crystal faces is calculated, including the contributions from temperature, oscillation, and dispersion corrections. © Allerton Press, Inc., 2012.

Yagoda A.V.,Stavropol State Medical Academy | Gladkikh N.N.,Stavropol State Medical Academy | Gladkikh L.N.,City Polyclinic No. 1 | Novikova M.V.,Stavropol Region Clinical Cardiology Dispanser | Saneeva G.A.,Stavropol State Medical Academy
Russian Journal of Cardiology | Year: 2013

Aim. To study the selected mediators of intracellular interactions and endothelial function in patients with myxomatous mitral valve prolapse (MVP). Material and methods. In total, 25 patients with myxomatous MVP, aged 18–29 years, were examined. The comparison groups included patients with MVP but no echocardiographic signs of myxomatosis and healthy individuals. The blood levels of the following mediators were measured: interleukin 1β (IL-1β), IL-4, IL-10, tumour necrosis factor α (TFN-α), interferon γ (IFN-γ), basic fibroblast growth factor (FGF-b), transforming growth factor β1 (TGF-1β), endopteline-1 (ET-1), nitric oxide (NO), thromboxane B2 (TxB2), 6-keto-prostagladine F1α (6-keto- PGF1α), and von Willebrand (vWF) factor activity. Results. MVP patients, regardless of the presence of myxomatosis, had elevated serum levels of TGF-β1 and FGF-b and decreased levels of TNF-α and vWF activity. In patients with myxomatous MVP, elevated levels of IL-1β and ET-1 and decreased levels of IFN-γ were registered, while the changes in the levels of FGF-b and vWF were the most pronounced. In both groups of participants with MVP, the levels of IL-6 and IL-10 were similar and close to the ones in controls. Among patients with myxomatous MVP, there was a tendency towards an increase in TxB2 and a decrease in NO and 6-keto- PGF1α levels. Conclusion. The most pronounced changes in the levels of mediators of intracellular interaction and endothelial function were observed in patients with echocardiographic signs of myxomatous MVP. © 2013, Silicea-Poligraf. All rights reserved.

Arushanyan E.B.,Stavropol State Medical Academy | Beier E.V.,Stavropol State Medical Academy
Eksperimental'naya i Klinicheskaya Farmakologiya | Year: 2015

Chronic stress produces some morphological changes in rats, including thymus weight reduction, adrenal hypertrophy, and peptic ulcers in stomach. Repeated administration of phytoadaptogenic drugs (ginseng and bilobil) decreased these stress-induced disorders. The antistressor activity of drugs was attenuated upon by removal of the pineal gland. Histochemical and morphometric investigation of pineal tissues in stressed animals showed that that the pharmacological effect was accompanied by increasing functional activity of the pineal gland. It is suggested that pineal mobilization may participate in antistressor activity of phytoadaptogenic drugs.

Evsevyeva M.E.,Stavropol State Medical Academy | Nikulina G.P.,Stavropol State Medical Academy | Sergeeva O.V.,Stavropol State Medical Academy | Baturina M.V.,Stavropol State Medical Academy | And 3 more authors.
Cardiovascular Therapy and Prevention (Russian Federation) | Year: 2011

Aim: To assess the correlations between office and ambulatory blood pressure (BP) levels and some cardiovascular risk factors (RFs) in healthy young people and young people with BP dysregulation.Material and methods: In total, 234 male and female students of the Stavropol State Medical Academy were examined (73 men, 161 women; age 18-23 years, mean age 21,4±0,2 years). The standard questionnaire included items on family history and behavioural risk factors. The examination also included anthropometry, psychological symptom questionnaire survey, office BP measurement, and ambulatory BP monitoring.Results: RFs of cardiovascular disease (CVD) were widely prevalent in the students examined, with the rates in males being 2-3 times higher than in females. Arterial hypertension (AH) was presented by its labile forms - isolated office AH and masked AH. Participants with these AH forms, compared to healthy students, were characterized by a greater number and greater strength of the correlations between office or ambulatory BP parameters and some CVD RFs.Conclusion: The association between labile AH and leading CVD RFs in young people points to the need for regarding individuals with labile AH as a risk group and for optimising preventive programs in students.

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