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Stana A.,University of Medicine and Pharmacy, Cluj-Napoca | Tiperciuc B.,University of Medicine and Pharmacy, Cluj-Napoca | Duma M.,State Veterinary Laboratory for Animal Health and Food Safety | Vlase L.,University of Medicine and Pharmacy, Cluj-Napoca | And 3 more authors.
Journal of Heterocyclic Chemistry | Year: 2014

A total of 17 new N-substituted derivatives (2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k and 3b, 3c, 3d, 3e, 3f, 3g, 3h) of 5-((2-phenylthiazol-4-yl) methylene) thiazolidine-2,4-dione (2a) and 5-(2,6-dichloro- benzylidene) thiazolidine-2,4-dione (3a) were synthesized. The structural elucidation of the newly synthesized compounds was based on elemental analysis and spectroscopic data (MS, 1H NMR, 13C NMR), and their antimicrobial activities were assessed in vitro against several strains of Gram-positive and Gram-negative bacteria and one fungal strain (Candida albicans) as growth inhibition diameter. Some of them showed modest to good antibacterial activity against Gram-negative Escherichia coli and Salmonella typhimurium and Gram-positive Staphylococcus aureus, Bacillus cereus, and Enterococcus fecalis bacterial strains, whereas almost all the compounds were inactive against Listeria monocytogenes. All of the synthesized compounds showed moderate to very good activity against C. albicans. © 2013 HeteroCorporation.


Rozsa T.,University of Medicine and Pharmacy, Cluj-Napoca | Duma M.,State Veterinary Laboratory for Animal Health and Food Safety | Vlase L.,University of Medicine and Pharmacy, Cluj-Napoca | Ionut I.,University of Medicine and Pharmacy, Cluj-Napoca | And 3 more authors.
Journal of Heterocyclic Chemistry | Year: 2015

Thiazole and bisthiazole derivatives represent a prevalent scaffold in the antimicrobial drug discovery. Therefore, we have decided to synthesize some new series of 4,5′-bisthiazoles. A total of 17 compounds were synthesized, their structural elucidation being based on elemental analysis (C,H,N,S) and spectroscopic data (MS and 1H NMR). Their in vitro antimicrobial activities were assessed against several Gram-positive and Gram-negative bacteria strains and also against one fungal strain (Candida albicans) using the difusimetric method. Some of the compounds showed modest to good antibacterial activity against Gram-negative Escherichia coli and Salmonella typhimurium and Gram-positive Staphylococcus aureus and Bacillus cereus bacterial strains. All of the synthesized compounds showed moderate to very good antifungal activity against C. albicans. © 2014 HeteroCorporation.


Tiperciuc B.,University of Medicine and Pharmacy, Cluj-Napoca | Zaharia V.,University of Medicine and Pharmacy, Cluj-Napoca | Colosi I.,University of Medicine and Pharmacy, Cluj-Napoca | Moldovan C.,University of Medicine and Pharmacy, Cluj-Napoca | And 5 more authors.
Journal of Heterocyclic Chemistry | Year: 2012

A series of new 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives have been synthesized starting from 2-aryl-4-methylthiazol-5-carbohydrazides and isonicotinic acid hydrazide. All the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and mass spectrometry. The synthesized compounds were screened for their antibacterial and antifungal activity, assessed as growth inhibition diameter. Some of them showed good antibacterial activity against gram positive Staphylococcus aureus, while the antibacterial activity against Listeria monocytogenes, Escherichia coli, and Salmonella typhymurium and antifungal activity against Candida albicans was modest. None of the tested compounds showed inhibitory activity against gram positive bacteria Enterococcus faecalis and Bacillus cereus and against gram negative bacteria Pseudomonas aeruginosa. © 2012 HeteroCorporation.


Stana A.,University of Medicine and Pharmacy, Cluj-Napoca | Tiperciuc B.,University of Medicine and Pharmacy, Cluj-Napoca | Duma M.,State Veterinary Laboratory for Animal Health and Food Safety | Pirnau A.,Romanian Institute of Isotopic And Molecular Technology | And 2 more authors.
Journal of the Serbian Chemical Society | Year: 2014

A series of new 5-(2,6-dichlorobenzylidene)thiazolidine-2,4-dione and 5-(4-methoxybenzylidene)thiazolidine-2,4-dione derivatives (3a-h and 5a-h, respectively) were synthesized starting from 5-arylidenethiazolidine- -2,4-dione and α-halo-ketones. The structural elucidation of the newly synthesized compounds was based on elemental analysis and spectroscopic data (MS, 1H-NMR and 13C-NMR). The synthesized compounds were screened in vitro for their antimicrobial activities against several pathogenic strains of Gram-positive and Gram-negative bacteria and one fungal strain (Candida albicans), as growth inhibition diameters. Some of the compounds displayed better inhibitory activities than that of the reference drug against the Gram- -positive Staphylococcus aureus, Bacillus cereus and Listeria monocytogenes bacterial strains, and showed good antifungal activity against C. albicans, while the antibacterial activity against the Gram-negative Escherichia coli and Salmonella typhimurium bacterial strains was moderate. © 2014 (CC) SCS.


Rad O.,University of Medicine and Pharmacy, Cluj-Napoca | Tibor R.,University of Medicine and Pharmacy, Cluj-Napoca | Duma M.,State Veterinary Laboratory for Animal Health and Food Safety | Vlase L.,University of Medicine and Pharmacy, Cluj-Napoca | And 4 more authors.
Studia Universitatis Babes-Bolyai Chemia | Year: 2016

Starting from 5-amino-2-mercapto-1,3,4-thiadiazole, 23 compounds, Schiff bases and S-mercapto-substituted derivatives, were synthesized. Their structural elucidation was based on elemental analysis, mass spectrometry and proton nuclear magnetic resonance spectroscopy (1H NMR). The screening of the antimicrobial activity of the title compounds was realized using the diffusimetric method against several strains of Gram-positive and Gramnegative bacteria and one fungal strain (Candida albicans). Some of the molecules showed moderate to good antibacterial activity against Gramnegative (S. typhimurium, E. coli) and better activity against Gram-positive (B. cereus, L. monocytogenes, S. aureus) bacterial strains. All compounds exhibited moderate to very good activity against C. albicans. Qualitative relationships (SAR) were also established between the chemical structures and the antimicrobial activity of these compounds. © 2016, Universitatea Babes-Bolyai, Catedra de Filosofie Sistematica. All Rights Reserved.

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