Founded in 1887, SUNY Buffalo Law School, the State University of New York is a graduate professional school at the University at Buffalo. It is part of the State University of New York system and is the SUNY system's only law school. U.S. News & World Report ranks the University at Buffalo Law School 100th in the nation for 2014. However, many lesser known sites rank the Law School much higher. The University at Buffalo Law School is No. 1 in Thomson Reuter's "Super Lawyers" ranking of law graduates practicing in Upstate New York, which includes 54 of the 62 counties in New York State. This is in addition to the UB Law School's 2010 national ranking, where it placed 48th out of the 180 law schools in the country that produced Super Lawyers, a measure which examines "twelve indicators of professional achievement". Also, Malcolm Gladwell, in the New Yorker Magazine, devised a formula that ranks UB within the top 50 whereas Reuters ranks UB Law as 48th overall in the nation.According to SUNY Buffalo Law School's 2013 ABA-required disclosures, 60.5% of the Class of 2013 obtained full-time, long-term, JD-required employment nine months after graduation. Wikipedia.
Auerbach A.,State University of New York at Buffalo
Neuropharmacology | Year: 2015
Abstract How does an agonist activate a receptor? In this article I consider the activation process in muscle nicotinic acetylcholine receptors (AChRs), a prototype for understanding the energetics of binding and gating in other ligand-gated ion channels. Just as movements that generate gating currents activate voltage-gated ion channels, movements at binding sites that generate an increase in affinity for the agonist activate ligand-gated ion channels. The main topics are: i) the schemes and intermediate states of AChR activation, ii) the energy changes of each of the steps, iii) the sources of the energies, iv) the three kinds of AChR agonist binding site and v) the correlations between binding and gating energies. The binding process is summarized as sketches of different conformations of an agonist site. The results suggest that agonists lower the free energy of the active conformation of the protein in stages by establishing favorable, local interactions at each binding site, independently. This article is part of the Special Issue entitled 'The Nicotinic Acetylcholine Receptor: From Molecular Biology to Cognition'. © 2014 Elsevier Ltd.
Li J.-X.,State University of New York at Buffalo
Behavioural Brain Research | Year: 2015
Pain and depression are two highly prevalent and deleterious disorders with significant socioeconomic impact to society. Clinical observations have long recognized the co-existence and interactions of pain and depression. However, the underlying mechanisms of pain-depression comorbidity and their dynamic interactions remain largely unknown. Preclinical animal studies may provide critical information for the understanding of this important comorbidity. This review analyzed the current preclinical evidence of interactions between pain and depression, which generally supports the causative relationship of the two conditions. In addition, the analysis proposed to apply domain interplay concept in future model development of pain-depression comorbidity and mechanism studies. The application of spectrum-centered animal models will better the understanding of pain-depression dyad and foster the development of more effective therapeutic strategies. © 2014 Elsevier B.V.
Gao W.,State University of New York at Buffalo
Advanced Drug Delivery Reviews | Year: 2010
Androgens function as sex hormone primarily via activation of a single androgen receptor (AR, or NR3C4). AR is an important therapeutic target for the treatment of diseases such as hypogonadism and prostate cancer. AR ligands of different chemical structures and/or pharmacological properties are widely used for these therapeutic applications, and all of the AR ligands currently available for therapy modulate AR function via direct binding to the ligand-binding pocket (LBP) of the receptor. In the past ten years, our understanding of AR structure and molecular mechanism of action has progressed extensively, which has encouraged the rapid development of newer generation of AR ligands, particularly tissue-selective AR ligands. With improved tissue selectivity, future generations of AR ligands are expected to greatly expand the therapeutic applications of this class of drugs. This review will provide an overview of the common therapeutic applications of currently available AR ligands, and discussion of the major challenges as well as novel therapeutic strategies proposed for future drug development. © 2010 Elsevier B.V.
Seery M.D.,State University of New York at Buffalo
Neuroscience and Biobehavioral Reviews | Year: 2011
Humans continually face situations that require actions to achieve valued goals with meaningful consequences at stake. Although the pursuit of such goals can be a negatively "stressful" experience, it is not necessarily so. According to the biopsychosocial model of challenge and threat, evaluations of personal resources and situational demands determine to what extent individuals experience a relatively positive (challenge) versus negative (threat) psychological state in this context. Challenge occurs when evaluated resources meet or exceed demands, whereas threat occurs when demands exceed resources. The challenge response thus reflects resilience in the face of potential stress. Because challenge and threat reliably result in distinct patterns of physiological changes, assessing cardiovascular responses in particular can provide valuable insight into underlying psychological processes. Research applying this methodology to individual differences (e.g., self-esteem level and stability and cumulative lifetime exposure to adversity) has implications for understanding how early life experience could contribute to resilience versus vulnerability to potential stress in daily life. © 2011 Elsevier Ltd.
Sachs F.,State University of New York at Buffalo
Physiology | Year: 2010
Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the cochlea require elaborate mechanical impedance matching to couple the channels to the external stress. In contrast, MSCs in nonspecialized cells appear activated by stress in the bilayer local to the channel-within about three lipids. Local mechanical stress can be produced by far-field tension, amphipaths, phase separations, the cytoskeleton, the extracellular matrix, and the adhesion energy between the membrane and a patch pipette. Understanding MSC function requires understanding the stimulus. ©2010 Int. Union Physiol. Sci/Am. Physiol. Soc.
Liu X.,State University of New York at Buffalo |
Swihart M.T.,State University of New York at Buffalo
Chemical Society Reviews | Year: 2014
The creation and study of non-metallic nanomaterials that exhibit localized surface plasmon resonance (LSPR) interactions with light is a rapidly growing field of research. These doped nanocrystals, mainly self-doped semiconductor nanocrystals (NCs) and extrinsically-doped metal oxide NCs, have extremely high concentrations of free charge carriers, which allows them to exhibit LSPR at near infrared (NIR) wavelengths. In this tutorial review, we discuss recent progress in developing and synthesizing doped semiconductor and metal oxide nanocrystals with LSPR, and in studying the optical properties of these plasmonic nanocrystals. We go on to discuss their growing potential for advancing biomedical and optoelectronic applications. © 2014 the Partner Organisations.
Free S.J.,State University of New York at Buffalo
Advances in Genetics | Year: 2013
The composition and organization of the cell walls from Saccharomyces cerevisiae, Candida albicans, Aspergillus fumigatus, Schizosaccharomyces pombe, Neurospora crassa, and Cryptococcus neoformans are compared and contrasted. These cell walls contain chitin, chitosan, β-1,3-glucan, β-1,6-glucan, mixed β-1,3-/β-1,4-glucan, α-1,3-glucan, melanin, and glycoproteins as major constituents. A comparison of these cell walls shows that there is a great deal of variability in fungal cell wall composition and organization. However, in all cases, the cell wall components are cross-linked together to generate a cell wall matrix. The biosynthesis and properties of each of the major cell wall components are discussed. The chitin and glucans are synthesized and extruded into the cell wall space by plasma membrane-associated chitin synthases and glucan synthases. The glycoproteins are synthesized by ER-associated ribosomes and pass through the canonical secretory pathway. Over half of the major cell wall proteins are modified by the addition of a glycosylphosphatidylinositol anchor. The cell wall glycoproteins are also modified by the addition of O-linked oligosaccharides, and their N-linked oligosaccharides are extensively modified during their passage through the secretory pathway. These cell wall glycoprotein posttranslational modifications are essential for cross-linking the proteins into the cell wall matrix. Cross-linking the cell wall components together is essential for cell wall integrity. The activities of four groups of cross-linking enzymes are discussed. Cell wall proteins function as cross-linking enzymes, structural elements, adhesins, and environmental stress sensors and protect the cell from environmental changes. © 2013 Elsevier Inc.
Chung D.D.L.,State University of New York at Buffalo
Carbon | Year: 2012
This paper reviews carbon materials for significant emerging applications that relate to structural self-sensing (a structural material sensing its own condition), electromagnetic interference shielding (blocking radio wave) and thermal interfacing (improving thermal contacts by using thermal interface materials). These applications pertain to electronics, lighting (light emitting diodes), communication, security, aircraft, spacecraft and civil infrastructure. High-performance and cost-effective materials in various forms of carbon have been developed for these applications. The forms of carbon materials include carbon fiber, carbon nanofiber, exfoliated graphite, carbon black and composite materials. Short carbon fiber cement-matrix composites and continuous carbon fiber polymer-matrix composites are particularly effective for structural self-sensing, with the attributes sensed including strain, stress, damage and temperature. Flexible graphite as a monolithic material and nickel-coated carbon nanofiber as a filler are particularly effective for electromagnetic shielding. Carbon black paste, graphite nanoplatelet paste and flexible graphite (filled with carbon black paste) are particularly effective for thermal interfacing; carbon nanotube arrays are less effective than these pastes. The associated science pertains to the relationship among processing, structure and properties in relation to the abovementioned applications. The criteria behind the design of materials for these applications and the mechanisms of the associated phenomena are also addressed. © 2011 Elsevier Ltd. All rights reserved.
Agency: NSF | Branch: Standard Grant | Program: | Phase: ITEST | Award Amount: 1.20M | Year: 2017
This project will advance efforts of the Innovative Technology Experiences for Students and Teachers (ITEST) program to better understand and promote practices that increase students motivations and capacities to pursue careers in fields of science, technology, engineering, or mathematics (STEM) by its focus on geotechnology (also called GIS or geospatial information systems) careers. The programmatic goal of this project is to prepare teachers to engage middle and high schools students in high-needs and high-potential school districts with cutting-edge web GIS knowledge and skills in order to motivate students to pursue formal school-based and informal out-of-school educational experiences. Project research, guided by social-cognitive career development theory and other work, will investigate what programmatic experiences contribute to student motivation and cognitive gains and what factors contribute to teacher integration of GIS content into the school curriculum.
During three years of the project, the project will offer a summer teacher workshop and a student GIS summer camp each year, The camp will include field trips to GIS-related industry and government agencies, supported by mentors from these organizations. The workshop and camp will support teachers and students in learning GIS concepts and skills. Teachers will also learn approaches to integrate GIS- and career-related in STEM and social studies classes. Students who attended the summer camp will be supported in organizing a GIS after-school club. This project will research one of the guiding questions of the ITEST program: What coherent sets of experiences effectively and efficiently support student competency, motivation and persistence for productive participation in the STEM-related workforce of today and the future? The project will use mixed methods research design including a quasi-experimental study. Research findings from this project will help educators better understand and address the context and factors that influence integration of GIS in middle and high school curricula.
Agency: NSF | Branch: Standard Grant | Program: | Phase: DATANET | Award Amount: 2.73M | Year: 2017
Big Data promises to have a positive impact on many aspects of our lives, but assembling the data to answer questions or derive predictive models can be challenging. Data scientists must typically go through multiple rounds of curation, or wrangling, where data are organized, refined, cleaned up, and merged together before they can be analyzed. Curation is often slow and costly, but is essential for obtaining useful and trustworthy answers. This project develops a software tool called Vizier that aims to streamline data curation and enable domain experts who do not have computer science expertise to curate their own data. Easier curation magnifies the value of big data by enabling a wide range of users to improve data quality, and in doing so benefits numerous types of data-driven work in government, industry, and science.
Vizier features an intuitive interface combining elements of notebooks and spreadsheets, allowing analysts to quickly see, edit, and revise data. This capability is complemented by a framework for automated data cleaning steps that are seamlessly integrated with manual curation operations. The heart of Vizier is a system for managing uncertainty and provenance of curation workflows and data, enabling the user to keep track of higher-level curation operations as well as track the lineage of data. By transparently maintaining the history of all the users actions and their effect on the curated data, Vizier enables regret-free exploration and curation where any changes to the data and their transitive effects can be undone. By learning from past curation histories, the system will also be able to provide users with context-dependent recommendations for additional curation actions.
This award by the Advanced Cyberinfrastructure Division is jointly supported by the NSF Directorate for Social, Behavioral and Economic Sciences (Division of Social and Economic Sciences).