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Villar L.,Industrial University of Santander | Dayan G.H.,Sanofi S.A. | Rivera D.M.,Organizacion para el Desarrollo y la Investigacion Salud en Honduras ODISH | Cunha R.,State University of Mato Grosso do Sul | And 15 more authors.
New England Journal of Medicine | Year: 2015

immunogenicity subgroup of 1944 children had seropositive status for one or more dengue serotypes. In the per-protocol population, there were 176 VCD cases (with 11,793 person-years at risk) in the vaccine group and 221 VCD cases (with 5809 person-years at risk) in the control group, for a vaccine efficacy of 60.8% (95% confidence interval [CI], 52.0 to 68.0). In the intention-to-treat population (those who received at least one injection), vaccine efficacy was 64.7% (95% CI, 58.7 to 69.8). Serotype-specific vaccine efficacy was 50.3% for serotype 1, 42.3% for serotype 2, 74.0% for serotype 3, and 77.7% for serotype 4. Among the severe VCD cases, 1 of 12 was in the vaccine group, for an intention-to-treat vaccine efficacy of 95.5%. Vaccine efficacy against hospitalization for dengue was 80.3%. The safety profile for the CYD-TDV vaccine was similar to that for placebo, with no marked difference in rates of adverse events. Conclusions The CYD-TDV dengue vaccine was efficacious against VCD and severe VCD and led to fewer hospitalizations for VCD in five Latin American countries where dengue is endemic. (Funded by Sanofi Pasteur; ClinicalTrials.gov number, NCT01374516.) Copyright © 2015 Massachusetts Medical Society. All rights reserved.

Brazilian Preventive Healthcare Policy has implemented important strategies to combat the spread of HIV/AIDS. However, there are some individuals that are theoretically not part of society who are catching and transmitting disease, namely prisoners. This population interacts with the community by means of relatives, visitors, prison wardens and repeat incarceration. The scope of this research is to establish the strategies developed to prevent the transmission and dissemination of STD/AIDS in Civil Police stations. A qualitative study was conducted with interns of the public prisons of four cities of the region of Naviraí in Mato Grosso do Sul State, and analysis was applied using the collective subject discourse technique. Results showed that despite acknowledging the importance of prevention, the male condom is only used in the first sexual encounter, and condoms are not used when intercourse is with a steady partner. The lack of orientation in relation to prevention of STD/ AIDS is well-known as is the lack of attention to the healthcare of prisoners, due mainly to prejudice and discrimination by society. It was revealed that a healthcare policy for prisoners also needs to be implemented in public prisons.

Ferreira A.C.,State University of Mato Grosso do Sul
Genetics and molecular research : GMR | Year: 2012

Insects use pheromones as a means of chemical communication. Pheromones act on individual receptors and produce specific behavioral or physiological responses that are fundamental to intra- and interspecific recognition. The objective of this study was to evaluate the interspecific differences among the linear hydrocarbon profiles of the cuticles of 3 wasp species of the genus Mischocyttarus. The chemical strategy that permits an interaction among 2 of these species was also examined about their hydrocarbon profiles. The cuticular hydrocarbons present on the abdomen of each individual were extracted with hexane in an ultrasonic bath and analyzed using gas chromatography with a flame ionization detector. The results suggested that the wasp species have distinct chemical signatures as the linear hydrocarbons of their cuticles. However, these signatures are more alike in those with similar morphological and behavioral aspects. These similarities facilitate an interaction of facultative parasitism observed among these species, in which the invaders acquire parts of the chemical signature of the host colony, possibly as a chemical strategy to increase the likelihood that an invader will be accepted by the females of a host colony. Both invader and host have their own chemical signature changed by the first contact between the species.

The objective of this study was to evaluate the effect of different concentrations (0; 50; 100 and 150 mg L-1) of paclobutrazol (PBZ) on growth, side shoot emission and yield of two tomato hybrids (Jennifer and AF 7631), cultivated in open field and in protected environment. The work was conducted from April to October of 2007, at UNESP - Campus of Ilha Solteira, State of São Paulo. The PBZ was applied to seedlings 15 days after sowing, and its effects were evaluated, considering the tested concentrations, for tomato plants after the transplant. A randomized blocks design was used, in a factorial scheme, with analysis for series of experiments, in a fixed model, consisting of 4 replicates for environment and 9 plants per plot. As results, the hybrid Jennifer showed higher rates of absolute growth, resulting in higher plants than AF 7631, on the 60th day after the transplantation, but, with no differences between them regarding side shooting and crop yield. In the greenhouse, higher plants were obtained, with higher side shooting and higher yield than that observed in the open field. The use of increasing concentrations of paclobutrazol reduced the height of plants and their growth rate, decreased side shooting, and reduced the crop yield.

Narciso V.,State University of Mato Grosso do Sul
Mathematical Methods in the Applied Sciences | Year: 2015

This paper is concerned with the existence of a global attractor for the nonlinear viscoelastic beam equation with past history memory utt + kΔ2u - ∫-∞ tμ(t - τ)Δ2u(τ) dτ + f(u) + g(ut) = h, where g(ut) is a damping like |ut|rut and f(u) is a source term like |u|αu - |u|βu, by considering 0 ≤ β < α and r > 0. Copyright © 2014 John Wiley & Sons, Ltd.

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