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Seidel A.C.,State University of MaringaParana | Cavalari P.,State University of MaringaParana | Rossi R.M.,State University of MaringaParana | Miranda F.,Federal University of Sao Paulo
Annals of Vascular Surgery | Year: 2016

Background The lack of the great saphenous vein (GSV) in its compartment is rarely mentioned in literature, although it happens in individuals with or without insufficiency of it. With the help of the B-mode ultrasound examination this vein can be easily identified. The aim of this study was to propose a classification for the findings. Methods Prospective study carried out for a period of 6 months in a sample of 2,665 lower limbs with ages ranging from 17 to 85, being that 1,286 patients are female. These patients underwent B-mode ultrasound examination as recommended by the literature. This evaluation determined whether there was a GSV aplasia by the analysis of its location in the saphenous compartment. Results After images were taken they were classified as: type I–aplasia only along the thigh, type II–aplasia only along the calf, type III–aplasia in the distal section of the thigh and proximal calf, type IV–vein in the saphenous compartment in the thigh and aplasia in the whole calf, type V–vein in the saphenous compartment only in a short segment in the proximal thigh, and type VI–vein with short segment in the saphenous compartment in the distal calf. From the total of 2,665 limbs, aplasia was found in 442 (16.6%). Conclusions These anatomic findings attain an important role in daily practice, influencing the surgical decision, particularly with the arrival of endovascular procedures, such as the use of laser and thermoablation. © 2016 Source

Spironello R.A.,State University of MaringaParana | Botura-Amado C.,State University of MaringaParana | Balensiefer T.K.,State University of MaringaParana | de Barros Carvalho M.D.,State University of MaringaParana | And 2 more authors.
Tropical Journal of Pharmaceutical Research | Year: 2015

This is a report on a case of neonatal sepsis and clinical management with multiple antibiotic therapy in a neonatal intensive care unit (NICU) in Brazil. A preterm baby boy was born by caesarean section at 34 weeks and two days of gestation from an oligodramnious pregnancy with intrauterine growth restriction. After respiratory failure detection, the baby was intubated and placed on mechanical ventilation for respiratory failure and was shifted to NICU. Ampicillin and gentamicin were instituted empirically. Enterobacter spp-induced severe sepsis was diagnosed. Included in the antibiotic therapy were oxacycline, amikacin, cefepime, tazocin, meropen and teicoplanin. After sixty days in NICU, clinical and laboratory parameters were normalized and the baby recovered. The empirical long-term antibiotic treatment and the use of broad spectrum antibiotics, as observed in the present case, should be carefully considered in newborns admitted to NICU. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved. Source

Koehnlein E.A.,Federal University of Parana | Koehnlein E.A.,State University of Maringa | Koehnlein E.M.,State University of MaringaParana | Correa R.C.G.,State University of Maringa | And 6 more authors.
International Journal of Food Sciences and Nutrition | Year: 2016

This work compares the phenolic contents and the total antioxidant capacity of the 36 most popular Brazilian foods submitted to aqueous extraction or in vitro digestion. The purpose was to evaluate the extent by which digestion differs from the simple aqueous extraction procedures of several food matrices. After in vitro digestion, cereals, legumes, vegetables, tuberous vegetables, chocolates and fruits showed higher phenolic contents and higher antioxidant activities than those obtained by aqueous extraction. Contrarily, the digestion caused a reduction in the phenolic contents and antioxidant activities of beverages (red wine, coffee and yerba mate). Our results suggest that the phenolics of food groups with solid and complex matrix are protected against enzymatic action and alteration in pH during the digestion, what does not occur in liquid food matrices such as the beverages. This fact would overestimate the antioxidant activities of beverages submitted solely to aqueous extraction. © 2016 Informa UK Limited, trading as Taylor & Francis Group. Source

Caleffi-Ferracioli K.R.,Health Science University | Caleffi-Ferracioli K.R.,State University of MaringaParana | Amaral R.C.R.,State University of MaringaParana | Demitto F.O.,State University of MaringaParana | And 8 more authors.
Tuberculosis | Year: 2016

Summary The aim of the present study was to (i) evaluate the in vitro action of rifampicin (RIF), ethambutol or isoniazid with efflux pumps inhibitors (EPIs) in Mycobacterium tuberculosis (Mtb) H37Rv and (ii) evaluate the morphological and efflux pumps (EPs) transcriptional changes by the action of rifampicin + verapamil combination (RIF + VP). The minimal inhibitory concentration and synergic effect of drug combinations were determined by Resazurin Microtiter Plate Assay and Resazurin Drugs Combination Microtiter Assay, respectively. VP showed greater capacity of ethidium bromide accumulation and RIF + VP had the lower fractional inhibitory concentration index. The RIF + VP exerted a similar reduction of viable cell counts to RIF by time-kill curve, but decreases in the expression of EPs genes were observed by Real time PCR at 72 h of RIF + VP exposure. Accumulative morphological changes (wrinkled and rounding) caused by each drug were observed by scanning electron microscopy after RIF + VP exposure. The downexpression of EPs related genes exposed to RIF + VP, suggest an effective inhibitory activity of VP in Mtb H37Rv. The role of EPs and the use of EPIs open up a powerful approach and the RIF + VP combination should be studied in Mtb more thoroughly. © 2016 Elsevier Ltd. All rights reserved. Source

Sfaciotte R.A.P.,Federal University of Parana | Bordin J.T.B.,State University of MaringaParana | Vignoto V.K.C.,State University of MaringaParana | Munhoz P.M.,State University of MaringaParana | And 5 more authors.
American Journal of Animal and Veterinary Sciences | Year: 2015

Otitis is one of the most frequent infections in dogs. This is attributed to the misuse of drugs enabling generation of multi-resistant micro-organisms. The emergence of multiresistant bacterial strains in veterinary medicine is a reality that must be studied and evaluated by the professionals. The objective of this study was to isolate and evaluate the antimicrobial susceptibility of bacterial pathogens of otitis in dogs. Otologic swabs were collected from 36 dogs with clinical otitis. 41 bacterial strains were isolated and antimicrobial susceptibility tests were performed by disk diffusion method with 34 antimicrobial agents. Presence of the resistance gene mecA of Staphylococcus was examined for 22 strains of staphylococci by PCR. A total of 1108 ratings antimicrobial agents were performed. The percentage of drug resistance was 34.66% (n = 384) of the assessments with partial or total resistance. Major bacterial pathogens were Staphylococcus spp. (65.85%), Pseudomonas spp. (12.19%) and Enterobacteria species (19.51%). 53.66% of the isolates were considered multiresistant. Antimicrobial agents considered most resistant in the strains studied were penicillin (75.00%), tetracyclin (50.00%), amoxicillin (48.78%), trimethoprimsulfamethoxazole (46.15%), clindamycin and rifampicin (43.24%). 11 strains were phenotypically characterized as MRS, 4 genotypically as MRS, 2 as MLSB-MRS and 2 as gram negative ESBL-producing. © 2015 Ricardo Antonio Pilegi Sfaciotte, Jéssica Taina Bordin Bordin, Vanessa Kelly Capoia Vignoto, Patrícia Marques Munhoz, Adriana Aparecida Pinto, Maria José Baptista Barbosa, Rejane Machado Cardozo, Sílvia Cristina Osaki and Sheila Rezler Wosiacki. Source

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