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Dhaka, Bangladesh

State University of Bangladesh or SUB is a private university in Dhanmondi, Dhaka, Bangladesh. It was established in 2002 under the Private University Act 1992. Wikipedia.

Tasmin S.,University of Tokyo | Furusawa H.,University of Tokyo | Ahmad S.A.,Bangladesh Institute of Health Science | Faruquee M.H.,State University of Bangladesh | Watanabe C.,University of Tokyo
Environmental Research | Year: 2015

Background and objective: Lead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and individual susceptibility. As children are more susceptible to lead-induced toxicity, this study investigated whether the ALAD genotype influenced urinary excretion of delta-aminolevulinic acid (U-ALA) among children exposed to environmental lead in Bangladesh. Methods: Subjects were elementary schoolchildren from a semi-urban industrialized area in Bangladesh. A total of 222 children were studied. Blood and urine were collected to determine ALAD genotypes, blood lead levels and urinary aminolevulinic acid (U-ALA). Results: The mean BPb level was 9.7. μg/dl for the study children. BPb was significantly positively correlated with hemoglobin (p<0.01). In total, allele frequency for ALAD 1 and 2 was 0.83 and 0.17 respectively. The mean U-ALA concentration was lower in ALAD1-2/2-2 carriers than ALAD1-1 carriers for boys (p=0.001). But for girls, U-ALA did not differ significantly by genotype (p=0.26). When U-ALA was compared by genotype at the same exposure level in a multiple linear regression analysis, boys who were ALAD1-2/2-2 carriers still had a lower level of U-ALA compared to ALAD1-1carriers. Conclusion: This study provides information about the influence of ALAD polymorphism and its association with U-ALA in Bangladeshi children. Our results indicate that the ALAD1-2/2-2 genotype may have a protective effect in terms of U-ALA for environmentally lead exposed boys. © 2014 Elsevier Inc. Source

Amin M.N.,Noakhali Science and Technology University | Liza K.F.,Noakhali Science and Technology University | Sarwar M.S.,Southeast University of Bangladesh | Ahmed J.,Noakhali Science and Technology University | And 4 more authors.
Archives of Dermatological Research | Year: 2015

The exact etiology and pathogenesis of eczema are not yet fully understood, although different factors are considered as pathogenic mechanisms in the development of eczema. Our study was designed to determine extent of serum lipid peroxidation, antioxidants, macro minerals and trace elements in patients with eczema, and thereby, find any pathophysiological correlation. The study was conducted as a case–control study with 65 eczema patients as cases and 65 normal healthy individuals as controls. Lipid peroxidation was assessed by measuring the serum level of malondialdehyde (MDA). Antioxidants- vitamin A and E concentration was determined by RP-HPLC method whereas vitamin C was evaluated for serum ascorbic acid by UV spectrophotometric method. Serum macro minerals (Na, K, Ca) and trace elements (Zn, Fe) were determined by Atomic Absorption Spectroscopy (AAS). This study found significantly higher level of MDA (p < 0.001) and lower level of antioxidants (p < 0.05) in patients in comparison to the control subjects. Analysis of serum macro minerals (Na, K and Ca) and trace elements (Zn, Fe) found that the mean values of Na, K, Ca, Zn and Fe were 2771.60 ± 75.64, 66.33 ± 3.03, 48.41 ± 2.50, 0.30 ± 0.02 and 0.29 ± 0.009 mg/L for the patient group and 3284.81 ± 34.51, 162.18 ± 3.72, 87.66 ± 2.10, 0.75 ± 0.06 and 0.87 ± 0.06 mg/L for the control group, accordingly. There was a significant difference for all the minerals between the patients and controls (p < 0.001). This study suggests a strong association between the pathogenesis of eczema with the elevated level of MDA and depleted level of antioxidants, macro minerals, and trace elements. © 2015, Springer-Verlag Berlin Heidelberg. Source

Islam M.R.,State University of Bangladesh | Ahamed R.,Southeast University of Bangladesh | Rahman M.O.,University of Dhaka | Akbar M.A.,University of Dhaka | And 3 more authors.
European Journal of Scientific Research | Year: 2010

In this study, methanolic crude extracts and their different fractions i.e. petroleum ether, carbon tetrachloride, chloroform and aqueous soluble fractions of the Allamanda cathartica (Family: Apocynaceae), Stereospermum personatum (Family: Bignoniaceae), Curcuma zedoaria (Family: Zingiberaceae), and Callistemon citrinus (Family: Myrtaceae) were subjected for antimicrobial activity. All the fractions were tested against different gram positive and gram negative bacteria and fungi to find out their antimicrobial activity using disc diffusion technique for bacteria and food poison method for fungi. Leaves' extract of Allamanda cathartica and Rhizome extract of Curcuma zedoaria showed mild to moderate antimicrobial activity where highest activity was observed by chloroform soluble fraction of Allamanda cathartica against Shigella dysenteriae (13 mm) and same activity of rhizome methanolic extract of Curcuma zedoaria was against Bacillus cereus (12 mm) and Vibrio parahemolyticus (12 mm). Chloroform solvent extract of Stereospermum personatum showed marked antibacterial activity against gram positive bacteria of Sarcina lutea (13 mm) and gram negative bacteria of Pseudomonas aeruginosa (13 mm). Leaves' carbon tetrachloride soluble fraction of Callistemon citrinus showed significant antimicrobial activity ranging from 11-16 mm zone of inhibition in diameter and its antimicrobial activity was highly significant especially against Vibrio parahemolyticus (16 mm), Vibrio mimicus (15 mm) and Sacharomyces cerevaceae (14 mm). Kanamycin at a concentration of 30 μg/disc was used as positive control in this study. © EuroJournals Publishing, Inc. 2010. Source

Maleque M.,State University of Bangladesh | Hasan M.R.,University of Dhaka | Hossen F.,University of Dhaka | Safi S.,University of Dhaka
Journal of Pharmaceutical Analysis | Year: 2012

A rapid, specific and economic UV spectrophotometric method has been developed using a solvent composed of water:methanol:acetonitrile (9:0.5:0.5) to determine the levofloxacin content in bulk and pharmaceutical dosage formulations. At a pre-determined λmax of 292 nm, it was proved linear in the range of 1.0-12.0 μg/mL, and exhibited good correlation coefficient (R2=0.9998) and excellent mean recovery (99.00-100.07%). This method was successfully applied to the determination of levofloxacin content in five marketed brands from Bangladesh and the results were in good agreement with the label claims. The method was validated statistically and by recovery studies for linearity, precision, repeatability, and reproducibility. The obtained results proved that the method can be employed for the routine analysis of levofloxacin in bulks as well as in the commercial formulations. © 2012 Xi'an Jiaotong University. Source

Sikder M.A.A.,University of Dhaka | Sharmin T.,State University of Bangladesh | Rahman A.F.M.M.,University of Dhaka | Haque M.R.,University of Dhaka | And 2 more authors.
Dhaka University Journal of Pharmaceutical Sciences | Year: 2013

The methanol extracts of leaves of Nephelium lappaceum L., Pandanus foetidus Roxb., Ludwigia repens Rubin. and the whole plant of Adiantum philippense L. were subjected to assays of antioxidant, cytotoxic, thrombolytic and membrane stabilizing activities. The antioxidant activity was evaluated by DPPH free radical scavenging activity using butylated hydroxytolune and ascorbic acid as standards. The crude extract of N. lappaccam exhibited the highest free radical scavenging activity (LC50= 3.93±0.25μg/ml). On the other hand, the crude methanol extracts of A. philippense and P. foetidus demonstrated significant brine shrimp lethality with LC50 values 0.50±0.84 μg/ml and 0.58±0.73 μg/ml, respectively as compared to the standard anti-neoplastic drug, vincristine sulfate (LC50= 0.45 μg/ml). Weak thrombolytic activity was observed for the test samples. The crude methanol extracts of P. foetidus and N. lappaceum showed 17.31±0.82 % and 17.29±0.91 % clot lysis while standard streptokinase and water, used as positive and negative controls, demonstrated 66.77 % and 3.79 % lysis of clot, respectively. The methanol extract of whole plant of A. philippense inhibited hypotonic solution and heat induced haemolysis of RBCs by 53.09±1.01 % and 35.36±1.60 % as compared to 71.77 % and 42.20 % by acetyl salicylic acid, respectively. Source

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