Dos Santos A.F.,Centro Universitario Cesmac |
Dos Santos A.F.,State University of Alagoas |
Fonseca S.A.,Centro Universitario Cesmac |
Cesar F.A.,Federal University of Pernambuco |
And 3 more authors.
Parasitology Research | Year: 2014
Jatropha elliptica is a shrub distributed throughout the north and west of Brazil and reputedly possesses a wide range of therapeutical properties. The roots of this plant possess molluscicidal activity and contain terpenoids, coumarin, lignoid, steroids and alkaloid. In the present study, we assessed the schistosomicidal, miracicidal and cercaricidal activities (against Schistosoma mansoni) and molluscicidal activities (against adults and egg masses of Biomphalaria glabrata) of the alkaloid diethyl 4-phenyl-2,6-dimethyl-3,5- pyridinedicarboxylate, isolated from the ethanol extract of the rhizome of J. elliptica, have been determined. The alkaloid was 100 % lethal to adult schistosomes within 4 days at a concentration of 50 μg/mL. Alterations were observed in the schistosome tegument occasioned by treatment with the alkaloid, such as formation of vesicles and vacuolisation. The extent of tegumental damage of the worm was proportional to the time of incubation and to the concentration of compound. The alkaloid also exhibited a potent cercaricidal activity (LC100 = 2 μg/mL); it was totally ineffective against miracicidal forms of the parasite. Moreover, the alkaloid presented strong activity against adult snails (LC90 = 36.43 μg/mL) but was inactive against their egg masses. It is observed then the potential of this compound for the development of new therapies for the treatment of schistosomiasis. © 2014 The Author(s).
PubMed | Federal University of Rio de Janeiro, Institute Cardiologia Of Porto Alegre, State University of Alagoas, Federal University of Goais and 2 more.
Type: Journal Article | Journal: Arquivos brasileiros de cardiologia | Year: 2016
A registry assessing the care of hypertensive patients in daily clinical practice in public and private centers in various Brazilian regions has not been conducted to date. Such analysis is important to elucidate the effectiveness of this care.To document the current clinical practice for the treatment of hypertension with identification of the profile of requested tests, type of administered treatment, level of blood pressure (BP) control, and adherence to treatment.National, observational, prospective, and multicenter study that will include patients older than 18 years with hypertension for at least 4 weeks, following up in public and private centers and after signing a consent form. The study will exclude patients undergoing dialysis, hospitalized in the previous 30 days, with class III or IV heart failure, pregnant or nursing, with severe liver disease, stroke or acute myocardial infarction in the past 30 days, or with diseases with a survival prognosis < 1 year. Evaluations will be performed at baseline and after 1 year of follow-up. The parameters that will be evaluated include anthropometric data, lifestyle habits, BP levels, lipid profile, metabolic syndrome, and adherence to treatment. The primary outcomes will be hospitalization due to hypertensive crisis, cardiocirculatory events, and cardiovascular death, while secondary outcomes will be hospitalization for heart failure and requirement of dialysis. A subgroup analysis of 15% of the sample will include noninvasive central pressure evaluation at baseline and study end. The estimated sample size is 3,000 individuals for a prevalence of 5%, sample error of 2%, and 95% confidence interval.The results will be presented after the final evaluation, which will occur at the end of a 1-year follow-up.The analysis of this registry will improve the knowledge and optimize the treatment of hypertension in Brazil, as a way of modifying the prognosis of cardiovascular disease in the country.
PubMed | Federal University of Alagoas, State University of Alagoas, Center for Research and Rehabilitation of Lip and Palate Lesions, University of Campinas and 5 more.
Type: Journal Article | Journal: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery | Year: 2016
The aim of this study was to use the TaqMan OpenArray system to evaluate associations between 39 genes and the etiology of nonsyndromic cleft lip and palate (NSCLP) in a Brazilian population.This case-control association study was designed with 80.11% statistical power according to logistic regression (GPOWER software). The case group had 182 patients with NSCLP enrolled in the Brazilian Database on Orofacial Clefts. The controls included 355 healthy individuals with no history of oral clefting in the past three generations. All samples were genotyped for 253 tag single nucleotide polymorphisms (tagSNPs) in 39 genes, including two that had recently been associated with this process. The association analysis was performed using logistic regression and stepwise regression. The results were corrected for multiple testing [Bonferroni correction and False Discovery Rate (FDR)].Twenty-four SNPs in 16 genes were significantly associated with the etiology of NSCLP, including MSX1, SPRY1, MSX2, PRSS35, TFAP2A, SHH, VAX1, TBX10, WNT11, PAX9, BMP4, JAG2, AXIN2, DVL2, KIF7, and TCBE3. Stepwise regression analysis revealed that 11 genes contributed to 15.5% of the etiology of NSCLP in the sample.This is the first study to associate KIF7 and TCEB3 with the etiology of NSCLP. New technological approaches using the same design should help to identify further etiological susceptibility variants.
Cavalcanti D.R.,Federal Rural University of Pernambuco |
Cavalcanti D.R.,State University of Alagoas |
Cavalcanti D.R.,Federal Institute of Education |
Albuquerque U.P.,Federal Rural University of Pernambuco
Evidence-based Complementary and Alternative Medicine | Year: 2013
Increases in ethnobotanical studies and knowledge in recent decades have led to a greater and more accurate interpretation of the overall patterns related to the use of medicinal plants, allowing for a clear identification of some ecological and cultural phenomena. "Hidden diversity" of medicinal plants refers in the present study to the existence of several species of medicinal plants known by the same vernacular name in a given region. Although this phenomenon has previously been observed in a localized and sporadic manner, its full dimensions have not yet been established. In the present study, we sought to assess the hidden diversity of medicinal plants in northeastern Brazil based on the ethnospecies catalogued by local studies. The results indicate that there are an average of at least 2.78 different species per cataloged ethnospecies in the region. Phylogenetic proximity and its attendant morphological similarity favor the interchangeable use of these species, resulting in serious ecological and sanitary implications as well as a wide range of options for conservation and bioprospecting. © 2013 Deyvson Rodrigues Cavalcanti and Ulysses Paulino Albuquerque.
Pequeno I.D.,Federal University of Vale do São Francisco |
Almeida N.M.,State University of Alagoas |
Filho J.A.S.,Federal University of Vale do São Francisco
Rodriguesia | Year: 2016
In Brazil, the genus Pseudobombax is represented by some 120 species occurring in different vegetation types. Bombacoideae species have nocturnal flowers and are bat and hawkmoth visited. The aim of the work was to investigate the reproductive biology of P. marginatum, and to describe the plant-floral visitors relationships. The study was carried out in a Caatinga area in Afrânio municipality, Pernambuco state. Phenology, floral biology, flower-visitor behavior and reproductive system were analyzed. P. marginatum has chiropterophilous flowers, although it is not visited by bats, a fact possibly related to the forest fragmentation process in the study area. The flowering period of the species was from May to July, - floral visitors were hawkmoths, bees, wasps and birds. Nectar production was high with low sugar concentration. Reproductive success was obtained only in cross pollination, due to the incompatibility mechanism. P. marginatum presents a critical situation for regeneration due to the lack of efficient pollination services, caused probably by forest fragmentation in the study area and the lack of chiropterans visitors.
PubMed | Federal University of Health Sciences, Porto Alegre, Federal University of Mato Grosso do Sul, State University of Alagoas and Nove de Julho University
Type: Journal Article | Journal: PloS one | Year: 2015
Previous studies have proposed only one prediction equation for respiratory muscle strength without taking into consideration differences between ages in pediatric population. In addition, those researches were single-center studies. The objective of this study was to establish reference equations for maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax) in children and teenagers. In a multicenter study, 450 healthy volunteers were evaluated (aged 6-18yrs). There were included volunteers with normal lung function. We excluded volunteers who could not perform the tests; participated in physical activity more than twice a week; were born prematurely; smokers; chronic respiratory, cardiologic, and/or neurologic diseases; had acute respiratory disease during the prior three weeks. The volunteers were divided into two groups: Group 6-11 (6-11yrs) and Group 12-18 (12-18yrs). PImax and PEmax were measured according to statement. The mean PImax value was 85.6 (95%IC 83.6-87.6 cmH2O), and PEmax 84.6 (95%IC 85.5-86.2 cmH2O). The prediction equations for PImax and PEmax for Group 6-11 were 37.458-0.559 + (age * 3.253) + (BMI * 0.843) + (age * gender * 0.985); and 38.556 + 15.892 + (age * 3.023) + (BMI * 0.579) + (age * gender * 0.881), respectively (R2 = 0.34 and 0.31, P<0.001). The equations for Group 12-18 were 92.472 + (gender * 9.894) + 7.103, (R2 = 0.27, P = 0.006) for PImax; and 68.113 + (gender * 17.022) + 6.46 + (BMI * 0.927), (R2 = 0.34, P<0.0001) for PEmax. This multicenter study determined the respiratory muscle strength prediction equations for children and teenagers.
Albuquerque P.D.,State University of Alagoas
Revista da Associação Médica Brasileira (1992) | Year: 2011
To identify what information is provided to the patients by oncologists, assess what they take into account in the process of informing the patient, and to ascertain whom the information is provided to. The study subjects were oncologists recruited among those registered at the Brazilian Society of Clinical Oncology - SBOC. All material was mailed to the Society, which was then forwarded to the participant oncologists. The previously stamped envelopes contained: a questionnaire, the questionnaire instructions, and the informed consent form to be signed. The data obtained was statistically treated, following a 95% confidence interval. 876 questionnaires were sent (total number of physicians registered at SBOC) and a 16.55% response rate was achieved. Regarding the information provided, 81% of the physicians responded they informed patients about diagnosis, treatment and prognosis; however, 73% reported that in most cases the patient is already aware of his/her disease. Nevertheless, the information is provided to the patient and his(her) family by 81% of doctors. Among the relevant aspects in the information process, the patient's gender has little influence on the information for 95% of doctors. Considering the results achieved, we conclude that in the study population, physicians are concerned about providing information according to the patient's profile. We could also notice that oncologists try to provide patients with the information they are entitled to - the truth, although they often resort to the family's assistance in providing that information.
Costa L.M.,Fisiocerapia da FAL |
Higino W.J.F.,Fisiocerapia da FAL |
De Jesus Leal F.,Federal University of São Paulo |
De Jesus Leal F.,State University of Alagoas |
And 2 more authors.
Jornal Vascular Brasileiro | Year: 2012
Background: Chronic venous disease (CVD) is to change the system causing a venous valvular incompetence associated with obstruction of flow or not. It affects 10 to 20% of world population, with higher prevalence in females. It presents as the most common symptoms and pain and swelling in advanced form, venous ulcer, and brings functional limitations, social isolation, affecting quality of life. Objective: Profiling of patients with CVD, the survey data indicate that clinical and socio-demographic characteristics that may contribute to possible change of habit in the life, who for reasons of work, lack of knowledge and/or instructions had affected their routine by the disease, with consequent decline in their quality of life. Methods: A descriptive, observational, cross-sectional study that evaluated patients with CVD treated at health centers in Maceió (AL) Brazil, applying a form for collecting data, such as CEAP, Brazil Criterion of Economic Classification Questionnaire and SF-36. Results: The sample consisted of 66 patients with CVD, 83% were female and 17% male. The patients had predominantly aged between 50 and 60 years who were sedentary, assuming prolonged standing, low educational level and economic status, severe clinical disease (symptomatic C6), and quality of life variable. Conclusion: The results showed a predominance of females, 50 to 60 years old, with triggering factors and/or aggravating factors for development of CVD as lack of physical activity, low education and low economic income, affecting quality of life.
Lima I.E.O.,State University of Alagoas |
Nascimento L.A.M.,State University of Alagoas |
Silva M.S.,State University of Alagoas
Revista Brasileira de Plantas Medicinais | Year: 2016
Medicinal Plants commercialization in the city of Arapiraca-AL. The marketing of medicinal plants in street fairs is part of the culture of many cities in the Northeast of Brazil. The aim of this study was to identify the marketing patterns of medicinal plants in Arapiraca-AL city. The methodologies involved semi-structured interviews, givento the merchants of medicinal plants, t after a Free and Clear Consent Form, by which the survey participants were aware of the risks and benefits of it and can stop it if necessary to judge, the interviews were recorded. Snow-ball and free list techniques were also used. The informants indicated 42 species; Fabaceae had the highest number of species. From the total of identified medicinal plants, 80% were native and the predominant habitat was arboreous. This study revealed that the production and marketing of medicinal plants has a local pattern, with the plants being acquired through outsourcing, and there is no minimum quality standard, requiring the implementation of public policies for the training of these professionals, adding value to the common knowledge of medicinal plants. © 2016, Instituto de Biociencias. All rights reserved.
da Silva A.A.S.,Maceio |
Trindade Filho E.M.,State University of Alagoas
Revista Neurociencias | Year: 2015
Objective. To compare the cerebral topographic mapping during divergent thinking. Method. The sample consisted of 11 volunteers and 11 volunteers accurate human, aged between 18 and 40 years. The participants underwent tests of divergent thinking, being designed by date show and electroencephalographic recording during playback. Results. During the activity of inventing names, there was predominance of rhythm in range of human group in the left anterior areas, right front and left rear area. Already in the activity of the alternative use of rhythm predominated in the group of exact range in the left rear area. Since the activity was higher mathematical processing of mental activity in the left anterior area in both groups. There was also an increased brain processing in the right rear area of the spot group. The group used human will over right anterior area during the activity of inventing names, while the group used more accurate the left rear area, this evidenced in the activity of the alternative use of objects. Conclusion. Showing the combination of rhythm with the range states of greater activation of the cerebral cortex during the planning and execution of cognitive activities .association gamma of rhythm with the range states of greater activation of the cerebral cortex during the programming and implementation of cognitive activities. © 2015, Universidade Federal de Sao Paulo. All rights reserved.