State Scientific Research Institute of Chemical Reagents and High Purity Chemical Substances IREA

Ul’yanovka, Russia

State Scientific Research Institute of Chemical Reagents and High Purity Chemical Substances IREA

Ul’yanovka, Russia
SEARCH FILTERS
Time filter
Source Type

Balaev A.N.,Pharm Sintez | Osipov V.N.,State Scientific Research Institute of Chemical Reagents and High Purity Chemical Substances IREA | Okhmanovich K.A.,Pharm Sintez | Ruchko E.A.,Pharm Sintez | And 2 more authors.
Russian Chemical Bulletin | Year: 2016

New Boc-protected pentapeptide amides of the general formula Boc—Cys(Boc)—Phe—d-Trp—Lys(Boc)—Thr—NHR, which are analogs of the natural hormone somatostatin, were synthesized. The cytotoxic activity of the new compounds was evaluated against the cancer cell lines MCF-7, PC 3, and HCT-116 by the MTT test, and some of these compounds were found to exhibit activity at micromolar concentrations. © 2016, Springer Science+Business Media New York.


Peregudov A.S.,RAS Nesmeyanov Institute of Organoelement Compounds | Artyushin O.I.,RAS Nesmeyanov Institute of Organoelement Compounds | Tcarkova K.V.,State Scientific Research Institute of Chemical Reagents and High Purity Chemical Substances IREA | Bondarenko N.A.,State Scientific Research Institute of Chemical Reagents and High Purity Chemical Substances IREA
Russian Chemical Bulletin | Year: 2015

Homoand heteronuclear NMR experiments (COSY, HSQC, and HMBC) were used for the attribution of the proton and carbon atom signals in the 1H and 13C NMR spectra of N-(ωalkoxyethyl)-N-(2-hydroxyethyl-)N, N-dimethylammonium chlorides Me2(HOCH2CH2)N+(CH2CH2O)nRCl– (n = 1, R = C9H19, C12H25; n = 2, R = C6H13, C12H25; n = 3, R = C3H7) bearing either one, two or three ethylene glycol units in 12-, 15-, and 18-membered substituents at the nitrogen atom. Performed experiments unambiguously confirmed the structures of the ammonium chloride studied. © 2015, Springer Science+Business Media New York.

Loading State Scientific Research Institute of Chemical Reagents and High Purity Chemical Substances IREA collaborators
Loading State Scientific Research Institute of Chemical Reagents and High Purity Chemical Substances IREA collaborators