State Scientific Research Institute Center for Physical science and Technology

Vilnius, Lithuania

State Scientific Research Institute Center for Physical science and Technology

Vilnius, Lithuania
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State Scientific Research Institute Center For Physical Science And Technology | Date: 2017-08-23

The present invention relates to a bioactive compound delivery assembly, a method for stabilization and/or encapsulation of bioactive compound compositions, a method for solid-supported transfection of living cells as well as a use of the bioactive compound delivery assembly.


Uglov V.V.,Belarusian State University | Uglov V.V.,Tomsk Polytechnic University | Abadias G.,University of Poitiers | Zlotski S.V.,Belarusian State University | And 5 more authors.
Journal of Surface Investigation | Year: 2015

The influence of ion irradiation (180-keV Xe2+ and doses of 1 × 1016 and 5 × 1016 cm–2) on the structure and phase composition of thin (300 nm) nanocrystalline (Ti,Zr)1–xSixNy films deposited via reactive magnetron sputtering (Si content x ≤ 0.22) is investigated. It is found that an increase in the Si concentration of the coating stimulates successive structure conversions from nanocrystalline (x < 0.07; grain size is about 18 nm) to nanocomposite (0.07 ≤ x ≤ 0.11; grain size is about 8 nm) and amorphous (x ≥ 0.18) states. The phase composition of the coatings varies from diphase (c-(Ti,Zr)N + a-TiSiNx) to amorphous (a-TiZrSiN). The nanocomposite coating consists of c-(Ti,Zr)N solid-solution grains (their size is ~8 nm) surrounded by an amorphous a-TiSiN matrix. Ion irradiation exerts no influence on the structural-phase state of the nanocrystalline and amorphous films. The diffraction peaks of the (Ti,Zr)N solid solution is revealed to be split because a double-layer structure is formed. This is associated with Xe-ion implantation into the coating. (Ti,Zr)N solid-solution grains are found to crystallize if amorphous coatings (0.18 ≤–≤ 0.22) are irradiated with xenon ions. © 2015, Pleiades Publishing, Ltd.


Makaraviciute A.,Vilnius University | Ruzgas T.,Malmö University | Ramanavicius A.,Vilnius University | Ramanavicius A.,State Scientific Research Institute Center for Physical science and Technology | Ramanaviciene A.,Vilnius University
Key Engineering Materials | Year: 2014

An immunosensor is an analytical system consisting of specific immune system molecules coupled to a signal transducer. Immunosensor sensitivity depends on the type of immunorecognition ligands used, immobilization influence on their activity and orientation on the surface. Quartz crystal microbalance with dissipation (QCM-D) was employed to investigate the immobilization of antibodies against bovine leukemia virus antigen gp51 (gp51). Disulphide bridges of antibody hinge region were reduced chemically to yield two "half" antibody fragments (Frag-Ab), each having a single antigen binding site and free sulfhydryl groups that were used for immobilization. Frag-Ab were immobilized on planar gold and gold nanoparticle (AuNP) modified QCM-D sensor surfaces from initial solutions of different concentrations. Higher Frag-Ab surface density values were obtained on AuNP modified surfaces at all tested antibody concentrations. Frag-Ab/gp51 specific interaction was registered and it was determined that the highest sensitivity was exhibited by Frag-Ab immobilized at the lowest surface desities on both types of investigated surfaces. Specific gp51 interaction with Frag-Ab and non-specific binding to bovine serum albumin modified surfaces were compared by employing Δf/ΔD plots, which could serve as "fingerprints" of different processes. © (2014) Trans Tech Publications.


Abromavicius G.,State Scientific Research Institute Center for Physical science and Technology | Abromavicius G.,Optida Co Ltd | Buzelis R.,State Scientific Research Institute Center for Physical science and Technology | Drazdys R.,State Scientific Research Institute Center for Physical science and Technology | And 7 more authors.
Lithuanian Journal of Physics | Year: 2011

The nonlinear LBO (LiB 3O 5) crystal is widely used in many Nd: YAG, Yb: KGW and Nd: YLF lasers in order to generate higher optical harmonics. However, the most limiting factor in such applications is the optical resistance of their coated surfaces described by the so-called Laser Induced Damage Threshold (LIDT) parameter. In this work we investigate the "fatigue" (multi-pulse) behaviour of LIDTs in LBO crystals coated with different types of (single AR@355 nm and triple AR@355+532+1064 nm wavelength) anti-reflective coatings while optimising the refractive index designs and selecting appropriate sub-layer materials. All the coatings were produced of different oxide materials (ZrO 2, Al 2O 3, SiO 2) and ZrO 2-SiO 2 mixtures by using the ion beam sputtering (IBS) deposition technique. The optical damage resistance of both fixed and transient refractive index coatings is of special interest. Besides the spectral properties, the resistance to laser irradiation is characterized at the wavelength of 355 nm with laser pulses of nanosecond duration. The conclusions are drawn about the AR coated LBO with the most successful designs by the means of optical resistance. © lietuvos mokslu{ogonek} akademija, 2011.


Remeikis V.,State Scientific Research Institute Center for Physical science and Technology | Juodis L.,State Scientific Research Institute Center for Physical science and Technology | Plukis A.,State Scientific Research Institute Center for Physical science and Technology | Vycinas L.,State Scientific Research Institute Center for Physical science and Technology | And 2 more authors.
Nuclear Engineering and Design | Year: 2012

The accumulation of long-lived 135Cs isotope in the ventilation system components of the Ignalina NPP Unit 2 was investigated by spectrometric measurements and mathematical modeling. Volumetric activities of fission noble gas and other short-lived isotopes ( 41Ar, 85mKr, 87Kr, 88Kr, 88Rb, 133Xe, 133mXe, 135Xe, 138Xe, 138Cs) have been measured by gamma spectrometric technique. Modeling of radionuclide transport in the ventilation system provides possibility of determining essential transport parameters: effective gas flow, mean gas retention time, deposition rate of aerosols. Estimated parameters were used for indirect evaluation of difficult to measure 135Cs isotope activity in the ventilation system components: a delay chamber and aerosol filters. The results show that the major part of 135Cs activity is accumulated in aerosol filters, whereas the total surface activity of the delay chamber is considerably lower. Specific activities of the ventilation system components of the Ignalina NPP Unit 2 are below the clearance levels for 135Cs. © 2011 Elsevier B.V. All rights reserved.


Kezionis A.,Vilnius University | Petrulionis D.,Vilnius University | Kazakevicius E.,Vilnius University | Kazlauskas S.,Vilnius University | And 2 more authors.
Electrochimica Acta | Year: 2016

Unique 2-electrode (100 mHz–10 GHz) and 4-electrode (100 mHz–2 MHz) impedance spectroscopy equipment enables investigation of the fine structure of oxygen ion conductive La2Mo2O9 (LMO) solid electrolytes ceramics’ impedance response in temperatures ranging from 300 to 950 K. Temperature dependencies of the electrical parameters show abrupt jumps associated with the α↔β-LMO phase transition, which is also detected by X-ray powder diffraction and differential scanning calorimetry analyses. Electrical relaxation phenomena are analyzed in terms of the relaxation time distribution function. Four different relaxation processes are identified and attributed to processes in the ceramics’ grains and grain boundary media. Detailed analysis of these processes reveals surprising findings about the nature of the α ↔ β-LMO phase transition, indicating that the abrupt change in LMO compound's resistivity is associated not only with a change in the relative volume of the different phases, but also with an alteration of the β-LMO phase itself; thus the α↔β-LMO phase transition is found to have properties of I and II order phase transitions. The methods applied in this paper could have wide application to the investigation of ionically conductive materials. © 2016 Elsevier Ltd


Masys S.,Vilnius University | Jonauskas V.,Vilnius University | Grebinskij S.,State Scientific Research Institute Center for Physical science and Technology | Mickevicius S.,State Scientific Research Institute Center for Physical science and Technology | And 2 more authors.
Lithuanian Journal of Physics | Year: 2013

We present a theoretical and experimental study of the electronic structure of SrRuO3 after introduction of vacancies. Theoretically, the modeling of non-stoichiometric variations of SrRuO3 was performed by removing appropriate atoms or their combinations, whereas in the experiments the annealing treatment at moderate temperatures in ultra-high vacuum was applied. At comparison of the obtained results allows us to draw an important conclusion that the formation of oxygen vacancies may be closely related to the manifestation of strong correlation effects in SrRuO3. © Lietuvos mokslu{ogonek} akademija, 2013.


Makaraviciute A.,Vilnius University | Ruzgas T.,Malmö University | Ramanavicius A.,Vilnius University | Ramanavicius A.,State Scientific Research Institute Center for Physical science and Technology | Ramanaviciene A.,Vilnius University
Analytical Methods | Year: 2014

Immunosensors are bioaffinity sensors incorporating immune system molecules that are utilized for analyte recognition and signal transduction yielding a measurable signal upon analyte detection. A lot of effort has been made to optimize the immobilization matrix on the sensor surface since the outcome of the ligand immobilization procedure determines sensitivity, specificity and longevity of the developed immunosensor. In this work, antibodies against bovine leukemia virus antigen gp51 were chemically reduced to "half" antibody fragments that were later employed as recognition ligands. Antibody fragments at different concentrations were immobilized via thiolate bonds on planar gold and gold nanoparticle modified surfaces of a quartz crystal microbalance with dissipation sensor. Antibody fragment immobilization and interaction with antigen were investigated. Antibody fragment surface mass densities after the immobilization on planar gold and gold nanoparticle modified sensor surfaces were directly dependent on the initial antibody concentration. The highest analytical response was exhibited by antibody fragments immobilized at the smallest surface mass density on planar gold and gold nanoparticle modified surfaces. Bovine leukemia virus antigen gp51 interaction with antibody fragments was compared with non-specific gp51 interaction with bovine serum albumin on planar gold and gold nanoparticle modified surfaces by employing ΔD/Δf plots. This journal is © the Partner Organisations 2014.


Juskevicius K.,State Scientific Research Institute Center for Physical science and Technology | Audronis M.,University of Sheffield | Subacius A.,State Scientific Research Institute Center for Physical science and Technology | Drazdys R.,State Scientific Research Institute Center for Physical science and Technology | And 3 more authors.
Applied Physics A: Materials Science and Processing | Year: 2014

ZrO2 exhibits low optical absorption in the near-UV range and is one of the highest laser-induced damage threshold (LIDT) materials; it is, therefore, very attractive for laser optics applications. This paper reports explorations of reactive sputtering technology for deposition of ZrO2 films with low extinction coefficient k values in the UV spectrum region at low substrate temperature. A high deposition rate (64 % of the pure metal rate) process is obtained by employing active feedback reactive gas control which creates a stable and repeatable deposition processes in the transition region. Substrate heating at 200 °C was found to have no significant effect on the optical ZrO2 film properties. The addition of nitrogen to a closed-loop controlled process was found to have mostly negative effects in terms of deposition rate and optical properties. Open-loop O2 gas-regulated ZrO2 film deposition is slow and requires elevated (200 °C) substrate temperature or post-deposition annealing to reduce absorption losses. Refractive indices of the films were distributed in the range n = 2.05-2.20 at 1,000 nm and extinction coefficients were in the range k = 0.6 × 10-4 and 4.8 × 10-3 at 350 nm. X-ray diffraction analysis showed crystalline ZrO2 films consisted of monoclinic + tetragonal phases when produced in Ar/O2 atmosphere and monoclinic + rhombohedral or a single rhombohedral phase when produced in Ar/O2 + N2. Optical and physical properties of the ZrO2 layers produced in this study are suitable for high-power laser applications in the near-UV range. © 2014 Springer-Verlag Berlin Heidelberg.

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