State Research Institute of Medicinal and Aromatic Plants

Moscow, Russia

State Research Institute of Medicinal and Aromatic Plants

Moscow, Russia
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Moustafine R.I.,Kazan State Medical University | Bukhovets A.V.,Kazan State Medical University | Garipova V.R.,Kazan State Medical University | Sitenkov A.Y.,Kazan State Medical University | And 4 more authors.
Pharmaceutical Chemistry Journal | Year: 2012

New interpolyelectrolyte complexes (IPECs) between oppositely charged Eudragit® EPO and Eudragit® L100 were investigated with a view to the development of oral controlled drug delivery systems (DDS). Structural features of the samples were evaluated by modulated-temperature differential scanning calorimetry (MTDSC). The results confirmed that all IPECs were chemically homogeneous and were characterized by only one glass-transition temperature. Evaluation of the diffusion-transport properties of the investigated IPECs revealed the basic mechanisms responsible for the controlled delivery of drugs with different physicochemical properties. The results showed that the synthesized IPECs have great potential to be used as pH-sensitive oral controlled DDS. © 2012 Springer Science+Business Media New York.


Mustafin R.I.,Kazan State Medical University | Bodrov A.V.,Kazan State Medical University | Kemenova V.A.,State Research Institute of Medicinal and Aromatic Plants | Rombaut P.,Catholic University of Leuven | Van Den Mooter G.,Catholic University of Leuven
Pharmaceutical Chemistry Journal | Year: 2012

Interpolymer interaction between countercharged copolymers Eudragit® RL30D (polycation) and Eudragit® FS30D (polyanion) was studied under simulated gastrointestinal tract conditions using FT-IR spectroscopy and modulated-temperature differential scanning calorimetry (MT-DSC) in order to find a mechanism for modifying diclofenac sodium release from an oral matrix delivery system. © 2012 Springer Science+Business Media, Inc.


Mustafin R.I.,Kazan State Medical University | Bobyleva V.L.,Kazan State Medical University | Kemenova V.A.,State Research Institute of Medicinal and Aromatic Plants
Pharmaceutical Chemistry Journal | Year: 2010

New interpolyelectrolyte complexes (IPECs) between oppositely charged types of Eudragit® EPO and Eudragit® L100-55 were investigated with a view to their application in oral controlled drug delivery systems. Monitoring of microenvironmental changes of polycomplex matrices in simulated gastro-intestinal fluids showed that all IPECs could have different pH-sensitivity characteristics. Evaluation of the diffusion transport properties of the investigated IPECs with diclofenac sodium confirmed that their swellability and release characteristics were closely correlated. The main possible mechanisms of control over the delivery of drugs to the desired regions of the gastro-intestinal tract are found. The results confirm that the proposed IPEC matrices have great potential to be used for controlled drug delivery. © 2010 Springer Science+Business Media, Inc.


Mustafin R.I.,Kazan State Medical University | Bilan A.B.,Kazan State Medical University | Bukhovets A.V.,Kazan State Medical University | Kemenova V.A.,State Research Institute of Medicinal and Aromatic Plants
Pharmaceutical Chemistry Journal | Year: 2011

New interpolyelectrolyte complexes (IPECs) between oppositely charged types of Eudragit EPO and Eudragit L100 were synthesized at pH 6.0, 6.5, and 7.0 with a view to their application in oral controlled drug delivery systems. Differences among the obtained IPECs were evaluated by FTIR spectroscopy and elemental analysis. The results confirm that the polycomplexes are stabilized by intermacromolecular ionic bonds and have compositions Z = 1.02, 1.49, and 2, respectively. Monitoring of microenvironmental changes in the polycomplex matrices during swelling in model gastrointestinal fluids indicates that all IPECs can be considered as potential pH-sensitive carriers due to structural and compositional transformations. The established properties of the synthesized IPECs suggest that they have high potential to be used as pH-dependent oral drug delivery systems. © 2011 Springer Science+Business Media, Inc.


Mustafin R.I.,Kazan State Medical University | Semina I.I.,Kazan State Medical University | Bukhovets A.V.,Kazan State Medical University | Sitenkov A.Yu.,Kazan State Medical University | And 3 more authors.
Pharmaceutical Chemistry Journal | Year: 2014

Drug delivery systems (DDSs) based on interpolyelectrolyte complexes (IPECs) of chemically complementary Eudragit® copolymers (EPO, L100, L100 - 55, and S100) and diclofenac sodium (DS) were compared with the original drug Voltaren® retard (VR) in a biopharmaceutical study in order to seek potential carriers for peroral DDSs. The proposed series of carriers were promising both in designing generic drugs (bioequivalent to VR) and in creating sustained-release and colon-specific targeting DDSs. © 2014 Springer Science+Business Media.


Rebrova G.A.,State Research Institute of Medicinal and Aromatic Plants | Bykov V.A.,State Research Institute of Medicinal and Aromatic Plants | Osipova L.A.,State Research Institute of Medicinal and Aromatic Plants | Rebrov L.B.,State Research Institute of Medicinal and Aromatic Plants | Vasilevsky V.K.,State Research Institute of Medicinal and Aromatic Plants
Biomeditsinskaya Khimiya | Year: 2011

In work chemical modification of collagen during action visible spectrum sunlight. These changes of collagen were found to indicate a photodegradation and photooxidation processes in collagen.

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