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Khadeev R.G.,State Research and Test Institute of Military Medicine
Russian Engineering Research | Year: 2010

A smooth starting mechanism such that the motor operates immediately in the intended conditions is proposed. This mechanism also eliminates current overloads. Thermal losses are small, and the torque at startup and at the onset of acceleration is much increased. © 2010 Allerton Press, Inc.


Vasin M.V.,State Research and Test Institute of Military Medicine | Antipov V.V.,State Research and Test Institute of Military Medicine | Komarova S.N.,State Research and Test Institute of Military Medicine | Semenova L.A.,State Research and Test Institute of Military Medicine | Galkin A.A.,State Research and Test Institute of Military Medicine
Biophysics | Year: 2011

The radioprotective properties of indralin when it is used in combination with cystamine and mexamine are studied in inbred mice and rats. The mice and rats are irradiated with γ rays emitted by 60Co at doses of 9.0 and 9.5 Gy, respectively. A combined parenteral administration of indralin and cystamine in mice at doses of 25 mg/kg each is revealed to potentiate the radioprotective properties of indralin up to a level close to the ED50 effect, while the separate application of these drugs in doses of 25 mg/kg each has no or a very weak radioprotective effect. Indralin (50 mg/kg) and mexamine (12 mg/kg) injected intraperitoneally in rats are found to almost completely eliminate the animal mortality caused by gastrointestinal acute radiation syndrome; the mortality in the control radiation group reaches 60% on the seventh day after the animals have been exposed to radiation at a dose of 9.5 Gy. However, if bone-marrow acute radiation syndrome develops under the above condition of super-lethal dose, the radioprotectors have a low radioprotective effect. Under the this condition, the combined application of indralin and mexamine in the same doses has 50% of radioprotective effect reached by applying these radioprotectors separately in double doses. © 2011 Pleiades Publishing, Ltd.


Vasin M.V.,State Research and Test Institute of Military Medicine | Ushakov I.B.,State Research and Test Institute of Military Medicine | Kovtun V.Y.,State Research and Test Institute of Military Medicine | Komarova S.N.,State Research and Test Institute of Military Medicine | And 4 more authors.
Biophysics | Year: 2011

Hybrid F1 mice (CBA × C57Bl/6) were subjected to irradiation at a nonlethal dose of 6. 7 Gy that brought on acute radiation sickness. In the experiments performed, we observed the beneficial effect of combined application of quercetin injected 30-60 min prior to irradiation with γ rays and the emergent radioprotector indralin injected after irradiation on development of postradiation repair in hematopoietic tissue. This effect was expressed as accelerated formation of endogenous spleen colonies and recovery of spleen weight and attenuation of leucopenia 12 and 16 days after acute irradiation. Treatment with only quercetin was not radioprotective. © 2011 Pleiades Publishing, Ltd.


Ushakov I.B.,Russian Academy of Sciences | Bednenko V.S.,State Research and Test Institute of Military Medicine
Human Physiology | Year: 2010

A project of an onboard medical support system (OMSS) for future aerospace system (ASS) flights is proposed. The following systems are suggested to be the main components of the OMSS: the basic system for automated estimation of blood redistribution (BSAEBR) in the body, protection and prophylactic means (PPM) for crew members, and the automated PPM control loop. The proposed BSAEBR includes four measurement channels for recording the basic physiological parameters (electrocardiogram, rheoencephalogram, venous-arterial pulsogram of neck blood vessels, and pulsogram of earlobe vessels), the changes in which are used to calculate, by means of a computer, the integrated parameter. The creation of lower body negative pressure (LBNP) was selected as a PPM. The automated PPM control loop individually selects the LBNP modes according to (1) the intensity of the body reactions and (2) individual characteristics of the physiological state. A working laboratory bench model of the OMSS has been manufactured and tested in two series of experiments simulating the conditions of a space flight. In the first series, 29 volunteers were exposed to -10 deg antiorthostatic hypokinesia (ANOH) for 6-8 h, as well as ANOH + LBNP. In the second series, 26 volunteers were exposed to the combination of ANOH, Coriolis acceleration, and optokinetic stimulation every 5-7 h for three days. The results have demonstrated that the use of the given OMSS ensures, on average, a 17-32% improvement of the psychophysiological parameters of an operator, with the changes in the head circulatory parameters being more favorable. © 2010 Pleiades Publishing, Ltd.

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