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Chen J.-C.,CAS Kunming Institute of Botany | Lau C.B.-S.,Chinese University of Hong Kong | Lau C.B.-S.,State Key Laboratory of Phytochemistry and Plant Resources in West China CUHK | Chan J.Y.-W.,Chinese University of Hong Kong | And 9 more authors.
Planta Medica | Year: 2015

Five new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5β,19-epoxycucurbit-23-en-7-on-3β,25-diol (1), 5β,19-epoxycucurbit-7,23-dion-3β,25-diol (2), 5β,19-epoxycucurbit-6-en-19,23-dion-3β,25-diol (3), 5β,19-epoxy-23,24,25,26,27-pentanorcucurbit-6-en-7,19-dion-3β,22-diol (4), and cucurbit-5-en-7,23-dion-3β,19,25-triol (5) by extensive spectroscopic and single-crystal X-ray diffraction analyses. Some cucurbitane compounds from this species were screened for their potential antidiabetic properties in terms of antigluconeogenic activity. As a result, compounds 1, 10, 11, and 12 (at 25-100 μM) showed concentration-dependent inhibition on glucose production from liver cells. In addition, compounds 11 and 12 (at 100 μM) showed around 20-30% inhibition on PEPCK activity. © Georg Thieme Verlag KG Stuttgart New York. Source

Lai P.,Chinese University of Hong Kong | Lai P.,State Key Laboratory of Phytochemistry and Plant Resources in West China CUHK | To M.-H.,Chinese University of Hong Kong | To M.-H.,State Key Laboratory of Phytochemistry and Plant Resources in West China CUHK | And 12 more authors.
Journal of Traditional and Complementary Medicine | Year: 2012

This study aimed to investigate and compare the fibroblast-proliferating activities of different Rehmanniae Radix (RR) samples and its chemical components using human normal fibroblast cells Hs27. Those active components were quantified in differently treated RR samples using UPLC so as to correlate activity with component content. Our results showed that dried RR aqueous extract exhibited the most potent fibroblast-proliferating activity. Stronger effect was observed when ethanol with heating was applied in the extraction process. Stachyose and verbascoside were demonstrated for their first time to exhibit significant stimulatory effects on fibroblast proliferation. However, the proliferating effect of dried RR extract did not correlate with the stachyose content, and verbascoside was not responsible for the fibroblast proliferative effect of RR since it was undetectable in all samples. In conclusion, stachyose only contributed in part to the activity of RR, suggesting that other active components might be present and yet to be found. Copyright © 2011 Committee on Chinese Medicine and Pharmacy, Taiwan. Source

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