Zhu Q.,State Key Laboratory of Natural Medicines and |
Zhu Q.,China Pharmaceutical University |
Ji D.,State Key Laboratory of Natural Medicines and |
Ji D.,China Pharmaceutical University |
And 4 more authors.
Organic Letters | Year: 2015
A novel and facile process for direct fluorination of unactivated C(sp3)-H bonds at the β position of carboxylic acids was accomplished by a palladium(II)-catalyzed C-H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of β-fluorinated carboxylic acids. © 2015 American Chemical Society.