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Zhu Q.,State Key Laboratory of Natural Medicines and | Zhu Q.,China Pharmaceutical University | Ji D.,State Key Laboratory of Natural Medicines and | Ji D.,China Pharmaceutical University | And 4 more authors.
Organic Letters | Year: 2015

A novel and facile process for direct fluorination of unactivated C(sp3)-H bonds at the β position of carboxylic acids was accomplished by a palladium(II)-catalyzed C-H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of β-fluorinated carboxylic acids. © 2015 American Chemical Society.

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