State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine

Linyi, China

State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine

Linyi, China
SEARCH FILTERS
Time filter
Source Type

Liu S.,Wuhan University of Science and Technology | Lv X.,State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine | Lv X.,Lunan Pharmaceutical Group Co. | Sun Z.,State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine | And 3 more authors.
Journal of Chinese Pharmaceutical Sciences | Year: 2015

Scutellaria baicalensis is widely cultivated in eastern Asia, particularly in China. In the present study, we isolated baicalin from this plant and studied for its hepatoprotective activity against CCl4-induced oxidative damage in rats. Our findings revealed that baicalin exhibited strong antioxidant activity in vitro. In established in vivo tests, baicalin showed effective protective effects by reducing the elevated levels of glutamate pyruvate transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB) and malondialdehyde (MDA) against CCl4-induced damage, and it restored the activities antioxidant defense substances, such as superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH), toward their normal levels. These data were supplemented with histopathological examination of rat liver sections. The results demonstrated that baicalin could be proposed to protect the liver against CCl4-induced oxidative damage in rats, and the possible underlying mechanism of the activity could be due to its free radical-scavenging and antioxidant activity. © 2015 Journal of Chinese Pharmaceutical Sciences, School of Pharmaceutical Sciences, Peking University.


Sun Z.,State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine | Su R.,State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine | Qiao J.,State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine | Zhao Z.,State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine | And 2 more authors.
Journal of Chemistry | Year: 2014

The Box-Behnken design combined with response surface method was employed to optimize ultrasonic-assisted extraction of flavonoids from Taraxacum officinale. The optimized results showed that the highest extraction yield with ultrasonic-assisted extraction could reach 2.62% using 39.6% (v/v) ethanol and 59.5: 1 (mL/g) liquid-solid ratio for 43.8 min. The crude extract was then purified by HPD-100 macroporous adsorption resin, and the flavonoids content in the purified extract increased to 54.7%. The antioxidant activity of the purified flavonoids was evaluated in vitro by scavenging capacity of ABTS or DPPH, β-carotene bleaching, and FTC test. The knowledge obtained from this study should be useful to further develop and apply this plant resource. © 2014 Zongxi Sun et al.

Loading State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine collaborators
Loading State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine collaborators