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Zhang J.-G.,Lanzhou University | Liu Q.,Huaqiao University | Liu Z.-L.,State Key Laboratory of Applied Organic Chemistry | Li L.,Huaqiao University | Yi L.-T.,Huaqiao University
Journal of Ethnopharmacology | Year: 2015

Ethnopharmacological relevance Anoectochilus roxburghii is a traditional Chinese herb used for treatment of diabetes and some other diseases. Anoectochilus roxburghii polysaccharose (ARP) is the main constituent of Anoectochilus roxburghii. The present study aimed to investigate the antidiabetic effects of ARP in diabetic mice induced by high-fat diet and streptozotocin. Materials and methods Two doses of ARP (100 or 300 mg/kg) were administered once daily for 25 days to diabetic mice. To evaluate the antidiabetic effects of ARP, the fasting glucose levels, aspartate aminotransferase (AST), alanine transaminase (ALT) and superoxide dismutase (SOD) activities, malondialdehyde (MDA) content, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and liver glycogen were examined. Furthermore, histological examinations were carried out on the separated pancreas and liver of mice. Results Compared with untreated diabetic mice, ARP (100 or 300 mg/kg) caused a significant decrease in blood glucose levels, activities of AST and ALT, and MDA contents, and a significant increase in liver glycogen contents, SOD activities, thymus index and spleen index. Simultaneously, the alteration in lipid metabolism was partially attenuated as evidenced by decreased serum TC, TG and LDL-C concentrations in diabetic mice. In addition, histological examinations showed that administration of ARP (100 or 300 mg/kg) significantly attenuated the pathologic lesions in pancreas and liver of diabetic mice, and improved pancreas and liver function. Conclusions The antidiabetic activity of ARP may be attributed to the improvement of glucose and lipid metabolism, increase of immune protection and reduction of oxidative stress. © 2015 Elsevier Ireland Ltd. All rights reserved. Source


Qin D.-D.,State Key Laboratory of Applied Organic Chemistry | Tao C.-L.,Lanzhou University | Friesen S.A.,Pennsylvania State University | Wang T.-H.,Pennsylvania State University | And 5 more authors.
Chemical Communications | Year: 2012

Films of crystalline WO 3 nanosheets oriented perpendicular to tungsten substrates were grown by a surfactant-free hydrothermal method, followed by sintering. The films exhibit photoelectrochemical oxygen evolution at low overpotential. © 2012 The Royal Society of Chemistry. Source


Zhu Z.,State Key Laboratory of Applied Organic Chemistry | Zhu Z.,Lanzhou University | Zhang Y.,State Key Laboratory of Applied Organic Chemistry | Zhang Y.,Lanzhou University | And 9 more authors.
Catalysis Communications | Year: 2016

Several new chiral oligomers of spiro-salenCo(III)X (spiro = 1.1′-spirobiindane-7.7′-diol) complexes have been designed, synthesized, and characterized by nuclear magnetic resonance (NMR), infrared (IR), and elemental analyses, in which, the chiral spiro moieties are first introduced into a scaffold of chiral salenCo catalysts. They were used to catalyze the asymmetric cycloaddition of epoxides with carbon dioxide. Under very mild reaction conditions, a kinetic resolution of racemic epoxides with CO2 was smoothly initiated by these chiral oligomer catalysts with good enantioselectivities, which can be attributed to the match effect between chiral backbones of salen and spiro. High stability and easy recyclability are their major advantages. © 2016 Elsevier B.V. All rights reserved. Source


Pan C.,Lanzhou University | Pan C.,State Key Laboratory of Applied Organic Chemistry | Wang W.,Lanzhou University | Wang W.,State Key Laboratory of Applied Organic Chemistry | And 3 more authors.
Chinese Journal of Chromatography (Se Pu) | Year: 2016

As the two enantiomers of chiral compounds have different chemical and physiologic properties, the enantioseparation of chiral compounds is of great significance in the fields such as medicine, biology, food and environment. Hence, the enantioseparation of different types of chiral compounds has become one of the hottest research topics in recent years. Capillary electrophoresis, owing to its unique advantages, has a wide application in the enantioseparation field recently. In this review, the latest research progresses in capillary electrophoresis enantioseparation are summarized from 2013 to 2015, and the future developments in this field is also prospected. © 2016 Science Press. Source


Chen T.,State Key Laboratory of Applied Organic Chemistry | Chen T.,Nanchang Hangkong University | Xu S.,State Key Laboratory of Applied Organic Chemistry | Zhao T.,State Key Laboratory of Applied Organic Chemistry | And 5 more authors.
ACS Applied Materials and Interfaces | Year: 2012

Two kinds of core-shell structured multifunctional nanocarriers of gold nanoclusters (Au NCs) as core and folate (FA)-conjugated amphiphilic hyperbranched block copolymer as shell based on poly(l-lactide) (PLA) inner arm and FA-conjugated sulfated polysaccharide (GPPS-FA) outer arm (Au NCs-PLA-GPPS-FA) were synthesized for targeted anticancer drug delivery. The structure and properties of Au NCs-PLA-GPPS-FA copolymers were characterized and determined by 1H NMR spectrum, FT-IR spectra, dynamic light scattering (DLS), fluorescence spectroscopy, and transmission electron microscopic (TEM) analyses. The anticancer drug, camptothecin (CPT) was used as a hydrophobic model anticancer drug. In vitro, two kinds of the nanocarriers presented a relatively rapid release in the first stage (up to 1 h) followed by a sustained release period (up to 15 h), and then reached a plateau at pH 5.3, 7.4, and 9.6. The release results indicated that CPT release from two kinds of the nanocarriers at pH 9.6 was much greater than that at both pH 5.3 and 7.4. The cytotoxicity studies showed that the CPT-loaded nanocarriers provided high anticancer activity against Hela cells. Furthermore, nanocarriers gained specificity to target some cancer cells because of the enhanced cell uptake mediated by FA moiety. The fluorescent images studies showed that the nanocarriers could track at the cellular level for advance therapy. The results indicated that the Au NCs-PLA-GPPS-FA copolymers not only had great potential as tumor-targeted drug delivery carrier, but also had an assistant role in the treatment of cancer. © 2012 American Chemical Society. Source

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