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Han Y.,Wuhan University of Technology | Li S.,Wuhan University of Technology | Li S.,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing | Cao X.,Wuhan University of Technology | And 8 more authors.
Scientific Reports | Year: 2014

Hydroxyapatite (HAP), similar to inorganic phase in bones, shows good biocompatibility and bioactivity as bone defect repairing material. Recently, nanoscaled HAP shows the special properties differing from bulk HAP in physics, chemistry and biology. This paper demonstrates that HAP nanoparticle (nHAP) possesses the ability for inhibiting cancer cell growth in vitro and in vivo. In vitro, after treatment with nHAP for 3 days, proliferation of human cancer cells are inhibited by more than 65% and by less than 30% for human normal cells. In vivo, injection of nHAP in transplanted tumor results in significant reduction (about 50%) of tumor size. The anticancer effect of nHAP is mainly attributed to high amount by endocytosis in cancer cells and inhibition on protein synthesis in cells. The abundant nHAP internalized in cancer cells around endoplasmic reticulum may inhibit the protein synthesis by decreasing the binding of mRNA to ribosome due to its high adsorption capacity for ribosome and arrest cell cycle in G0/G1 phase. nHAP shows no ROS-involved cytotoxicity and low cytotoxicity to normal cells. These results strongly suggest that nHAP can inhibit cancer cell proliferation and have a potential application in cancer treatment. Source


Lemaire A.,University of Namur | Su B.-L.,University of Namur | Su B.-L.,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing
Studies in Surface Science and Catalysis | Year: 2010

Porous materials have been prepared via a single-source pathway. A one-step synthesis pathway has been developed for the design of hierarchically structured macro-mesoporous aluminosilicates with high tetrahedral aluminium content from a single molecular alkoxide precursor already containing Si-O-Al bonds (sec-BuO)2-Al-O-Si(OEt)3. The compensation of the cleavage of the intrinsic Al-O-Si linkage is successfully achieved by using highly alkaline media and the employment of reactive silica co-reactants, or aluminium selective chelating agents, leading to aluminosilicate materials with Si/Al ratios close to one and very high proportion of tetrahedral aluminium species. The macro-mesoporosity was spontaneously generated by the hydrodynamic flow of solvents released during the rapid hydrolysis and condensation processes of this double alkoxide. Secondly, recent advances in the conception of mesoporous zirconosilicate with homogeneous repartition of zirconium into the silicate structure (Si/Zr ∼ 4), achieved by the use of Zr[OSi(O sBu)3]4 molecular precursor, are presented. © 2010 Elsevier B.V. Source


Barakat T.,University of the Littoral Opal Coast | Rooke J.C.,University of Namur | Genty E.,University of the Littoral Opal Coast | Cousin R.,University of the Littoral Opal Coast | And 4 more authors.
Energy and Environmental Science | Year: 2013

This review presents studies and investigations of the use of gold catalysts in environmental applications, from the oxidation of CO and volatile organic compounds (VOCs) in environmental technologies to the production of hydrogen, a non-polluting energy source, in the water-gas shift (WGS) reaction. It summarizes a variety of results, from the discovery made by Haruta et al. about the catalytic behaviour of gold in CO oxidation, to the use of gold-based catalysts in environmental remediation, by the catalytic removal of different types of VOC using a wide variety of oxide supports and finally to the use of this highly active noble metal in WGS applications. It also discusses gold loading methods, comparing them in terms of simplicity, efficiency and the resultant particle size and dispersion of Au over various supports. The application of different types of supporting materials is also presented, with a critical discussion of the parameters affecting the choice and use of such materials, i.e. how the support interacts with gold particles and with pollutant molecules along with the advantages a support offers to VOC oxidation and WGS reactions. It ends by highlighting the potential of gold catalyts in the future. This journal is © The Royal Society of Chemistry 2013. Source


Wang Y.T.,Huazhong University of Science and Technology | Liu W.,Huazhong University of Science and Technology | Fan A.W.,Huazhong University of Science and Technology | Li P.,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing
Applied Mechanics and Materials | Year: 2013

The connections between the thermoelectric modules are crucial importance for the performance of the thermoelectric power system. Many studies have been done to improve the output of thermoelectric system, but very little specific to the connections between the modules. A mathematical model of a module has been established, and based on this model, the performance of two systems composed of 6 pieces of thermoelectric modules, one in series connection and the other in parallel connection, is simulated with MATLAB software and then compared. The results can be used as reference for the design and prediction of thermoelectric system. © (2013) Trans Tech Publications, Switzerland. Source


Zhang W.,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing | Wang Y.-L.,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing | Zhao S.-L.,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing | Zhao S.-L.,Wuhan University of Technology | Guan J.-G.,State Key Laboratory of Advanced Technology for Materials Synthesis and Processing
Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities | Year: 2012

Using silver coated glass microsphere composite particles(Ag/GM) synthesized by liquid chemical reduction method as raw materials, and ethylenediamine as surface modification agents, Ag/GM with ethylenediamine on their surface were prepared and used as conductive fillers to fabricate electrically conductive adhesive. Compared with the Ag/GM synthesized by chemical reduction method and modified with boiling water, the Ag/GM modified with ethylenediamine are dispersed in the epoxy adhesive more effectively and the interface energy between them and epoxy resin matrix is reduced because of the formation of the chemical bonding between the epoxy resin and the ethylenediamine adsorbed on the surface of Ag/GM. The as-fabricated electrically conductive adhesives show a relative high conductivity and low conductive percolation threshold, which is reasonably explained by the conductive percolation theory and equivalent circuit diagram. The result provides a simple and effective way to improve the conductivity of electrically conductive adhesive. Source

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