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Gou Y.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | Gou Y.,Guangxi Normal University | Yang F.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | Yang F.,Guangxi Normal University | And 2 more authors.
Current Topics in Medicinal Chemistry | Year: 2016

Human serum albumin (HSA) is the most abundant protein in the plasma. HSA plays a central role in drug pharmacokinetics because most drugs bound to HSA are delivered to their target organ/tissues. The prodrug strategies have shown great promise for improving the activity and selectivity of drugs. Designing prodrugs based on special HSA residues, such as Cys34 and Lys residues, has been extensively studied. Therefore, this review provides an overview of the development of nonsteroidal anti-inflammatory and anticancer prodrugs based on these special residues. In conclusion, this review may guide the rational design and development of new prodrugs for future clinical applications. © 2016 Bentham Science Publishers Source


Li J.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | Xu L.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | Wang L.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | Liang A.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | Jiang Z.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources
Chinese Journal of Chemistry | Year: 2012

In pH 7.2 Na 2HPO 4-NaH 2PO 4 buffer solution and in the presence of PEG-6000, goat-anti-human factor B (GABF) was combined with human factor B (BF) specifically, and aggregated to form immune complex particles that exhibited a resonance scattering (RS) peak at 400 nm. The laser scattering indicated that the average diameter of immune complex particles was 1320 nm. BF in the concentration range of 0.04 to 9.60 μg/mL was proportional to the resonance scattering intensity at 400 nm. Its regression equation was ΔI=33.61C+ 1.4, with a correlation coefficient of 0.9969, and a detection limit of 0.01 μg/mL BF. This label-free resonance scattering spectral (RSS) method has been applied to the determination of BF in serum samples, and the results were in agreement with that of the immunoturbity. Copyright © 2012 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Wang S.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | Wang S.,Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection | Wang S.,Guangxi Normal University | Xu L.,State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources | And 11 more authors.
Luminescence | Year: 2013

Graphite oxide (GO) was prepared by the Hummer procedure, and can be dispersed to stable colloid solution by ultrasonic wave. The GO exhibited an absorption peak at 313 nm, and a resonance Rayleigh scattering (RRS) peak at 490 nm. In pH 4.6 HAc-NaAc buffer solution, human serum albumin (HSA) combined with GO probe to form large HSA-GO particles that caused the RRS peak increasing at 490 nm. The increased RRS intensity was linear to HSA concentration in the range 0.50-200 μg/mL. Thus, a new and simple RRS method was proposed for the determination of HSA in samples, with a recovery of 98.1-104%. Copyright © 2012 John Wiley & Sons, Ltd. Copyright © 2012 John Wiley & Sons, Ltd. Source

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