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Wu J.,State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering | Kang S.,State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering | Yuan Q.,State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering | Luo L.,State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering | And 3 more authors.
Molecules | Year: 2012

A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed >90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed. Source

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