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Liu J.-L.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Liu J.-L.,Chengdu University of Traditional Chinese Medicine | Li X.-H.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Li X.-H.,Chengdu University of Traditional Chinese Medicine | And 11 more authors.
Phytochemistry Letters | Year: 2015

Four nor-β-patchoulene sesquiterpenoids including three new compounds (1-3) and a new natural product (4) were isolated from the essential oil of the leaves and stems of Pogostemon cablin. Their structures were elucidated by detailed spectroscopic analysis, using 1D- and 2D-NMR techniques. This is the first report of 4-nor-β-patchoulenes from plants. All isolates were evaluated for the cytotoxic activities on human cancer cells in vitro. Compound 3 showed weak cytotoxic activities against NCI-H1975 and HePG-2 with IC50 values of 49.9 μg/mL and 56.0 μg/mL, respectively. © 2015 Phytochemical Society of Europe. Source


Xiong L.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Xiong L.,Key Laboratory of Standardization of Chinese Herbal Medicine | Xiong L.,Chengdu University of Traditional Chinese Medicine | Peng C.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | And 23 more authors.
Molecules | Year: 2012

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2- carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity. Source


Li X.-H.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Li X.-H.,Chengdu University of Traditional Chinese Medicine | Guo L.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Guo L.,Chengdu University of Traditional Chinese Medicine | And 14 more authors.
Phytochemistry Letters | Year: 2014

Three new neolignan glucosides (1-3), together with four known analogs (4-7), have been isolated from the stems of Dendrobium aurantiacum var. denneanum. Structures of the new compounds including the absolute configurations were determined by spectroscopic and chemical methods as (-)-(8R,7′E)-4- hydroxy-3,3′,5,5′-tetramethoxy-8,4′-oxyneolign-7′-ene-9, 9′-diol 4,9-bis-O-β-d-glucopyranoside (1), (-)-(8S,7′E)-4- hydroxy-3,3′,5,5′-tetramethoxy-8,4′-oxyneolign-7′-ene-9, 9′-diol 4,9-bis-O-β-d-glucopyranoside (2), and (-)-(8R,7′E)-4- hydroxy-3,3′,5,5′,9′-pentamethoxy-8,4′-oxyneolign- 7′-ene-9-ol 4,9-bis-O-β-d-glucopyranoside (3), respectively. © 2014 Phytochemical Society of Europe. Source

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