State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources

Chengdu, China

State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources

Chengdu, China
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Xiong L.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Xiong L.,Key Laboratory of Standardization of Chinese Herbal Medicine | Xiong L.,Chengdu University of Traditional Chinese Medicine | Peng C.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | And 23 more authors.
Molecules | Year: 2012

Two new alkaloids, aconicarmine (1) and aconicaramide (5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (2), neoline (3), N-ethylhokbusine B (4), 5-hydroxymethylpyrrole-2- carbaldehyde (6), and oleracein E (7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds 2 and 3 showed activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds 5 and 7 showed moderate antibacterial activity.


Liu J.-L.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Liu J.-L.,Chengdu University of Traditional Chinese Medicine | Li X.-H.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Li X.-H.,Chengdu University of Traditional Chinese Medicine | And 11 more authors.
Phytochemistry Letters | Year: 2015

Four nor-β-patchoulene sesquiterpenoids including three new compounds (1-3) and a new natural product (4) were isolated from the essential oil of the leaves and stems of Pogostemon cablin. Their structures were elucidated by detailed spectroscopic analysis, using 1D- and 2D-NMR techniques. This is the first report of 4-nor-β-patchoulenes from plants. All isolates were evaluated for the cytotoxic activities on human cancer cells in vitro. Compound 3 showed weak cytotoxic activities against NCI-H1975 and HePG-2 with IC50 values of 49.9 μg/mL and 56.0 μg/mL, respectively. © 2015 Phytochemical Society of Europe.


Li X.-H.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Li X.-H.,Chengdu University of Traditional Chinese Medicine | Guo L.,State Key Laboratory Breed Base Of Systems Res Development And Utilization Of Chinese Medicine Resources | Guo L.,Chengdu University of Traditional Chinese Medicine | And 14 more authors.
Phytochemistry Letters | Year: 2014

Three new neolignan glucosides (1-3), together with four known analogs (4-7), have been isolated from the stems of Dendrobium aurantiacum var. denneanum. Structures of the new compounds including the absolute configurations were determined by spectroscopic and chemical methods as (-)-(8R,7′E)-4- hydroxy-3,3′,5,5′-tetramethoxy-8,4′-oxyneolign-7′-ene-9, 9′-diol 4,9-bis-O-β-d-glucopyranoside (1), (-)-(8S,7′E)-4- hydroxy-3,3′,5,5′-tetramethoxy-8,4′-oxyneolign-7′-ene-9, 9′-diol 4,9-bis-O-β-d-glucopyranoside (2), and (-)-(8R,7′E)-4- hydroxy-3,3′,5,5′,9′-pentamethoxy-8,4′-oxyneolign- 7′-ene-9-ol 4,9-bis-O-β-d-glucopyranoside (3), respectively. © 2014 Phytochemical Society of Europe.

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