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Zhang H.,Hunan University | Cai Y.,State Key Laboratory and Hunan Breeding Base for Chinese Medicine Powder and Innovative Drugs | Tan Z.,State Key Laboratory and Hunan Breeding Base for Chinese Medicine Powder and Innovative Drugs | Zhou S.,State Key Laboratory and Hunan Breeding Base for Chinese Medicine Powder and Innovative Drugs | And 3 more authors.
Chinese Journal of Applied and Environmental Biology | Year: 2014

To study the microecological mechanism for ultra-micro Qiweibaizhusan on diarrhea with intestinal dysbacteriosis, the mice were modeled dysbacteriosis by stomach injection of mixed cefradine and gentamycin sulfate. Then the mice in one treatment group were given the traditional decoction of Qiweibaizhusan; those in the other treatment group were given 1/2 dose of ultra-micro powder of Qiweibaishusan; and those in the normal group and model group were given steriled water, all through intragastric administration. After three days the intestinal microflora were extracted, and their metabolism were determined by Biolog Microbial Identification System. Results showed that the AWCD of all groups tended to stabilize through 72 h of cultivating, with the normal group > the 1/2 dose of ultra-micro powder group > the traditional decoction group > the model group. The microbial diversity index including Shannon index, Shannon evenness, Simpson index and Mcintosh index of the normal group were the largest, significantly different from other groups (P < 0.01). The Shannon index, Simpson index of the 1/2 dose of ultra-micro powder group and the Shannon evenness, Mcintosh index of the traditional decoction group were in the second. The results of clustering analysis and principal components analysis suggested obvious bacteriostasis of antibiotics that influenced some metabolism pathways of intestinal microbial in mice influenced. The metabolism diversity of intestinal microbial in mice gradually regained balance through the regulatory functions of 1/2 dose of ultra-micro powder and traditional decoction of Qiweibaishusan. The regulation role of 1/2 dose of ultra-micro powder was more notable than that of the traditional decoction. The Ultra-micro Qiweibaizhusan is effective in regulating metabolism diversity of intestinal microbial in mice and treating diarrhea with intestinal dysbacteriosis. Source

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