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de Almeida M.H.,Federal University of Rio de Janeiro | Dantas J.R.,Federal University of Rio de Janeiro | Dantas J.R.,State Institute of Diabetes and Endocrinology Luiz Capriglione IEDE | Barone B.,Federal University of Rio de Janeiro | And 9 more authors.
Clinics | Year: 2013

Objective: To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations. Method: Eighty-eight patients with a mean disease duration of 8.1 +7.6 years were included and underwent C-peptide measurement before and after glucagon stimulation. Chi-squared and Mann Whitney U-tests were used to compare the variables between groups (all two-tailed, a = 0.05). Spearmans correlation coefficient was used to test the association between the continuous variables. Logistic regression was used for the multivariate analysis. Twenty-eight (31.8%) individuals had significantly detectable C-peptide levels after stimuli, particularly those with a shorter disease duration (p<0.001). Results: Patients with detectable C-peptide levels required lower insulin doses (p<0.009) and had similar HbA1C results (p = 0.182) and fewer chronic complications (p = 0.029). Conclusion: C-peptide detection was common in Type-1 diabetics, particularly shortly after being diagnosed. This result may have clinical implications. © 2013 CLINICS.


Dantas J.R.,Federal University of Rio de Janeiro | Dantas J.R.,State Institute of Diabetes and Endocrinology Luiz Capriglione IEDE | Almeida M.H.,Air Force Central Hospital HCA | Barone B.,State Institute of Diabetes and Endocrinology Luiz Capriglione IEDE | And 7 more authors.
Diabetes Research and Clinical Practice | Year: 2013

C peptide (CP) was evaluated in 88 individuals with type 1 diabetes, variable disease duration and multiethnic background. Initially, 28 patients had detectable CP, which persisted in 46.2% after 17.4 ± 4 months. CP decline was associated with ethnicity, HbA1c and baseline CP, but not with GADA, PTPN22 or insulin gene polymorphisms. © 2013 Elsevier Ireland Ltd.

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