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Nalini D.,University of Madras | Karthick R.,University of Madras | Shirin V.,University of Madras | Manohar G.,Stanley Medical College and Hospital | Malathi R.,University of Madras
Thrombosis Journal | Year: 2015

Background: Obesity is currently regarded as a pro-inflammatory condition during which leptin (Ob gene product) might act as a risk factor for Cardiovascular Diseases (CVD) including Acute Myocardial Infarction (AMI). There is a marked increase in circulating leptin concentrations and inflammatory markers such as Tumor Necrosis Factor-α (TNF-α) in AMI patients but still the association of leptin with inflammation during AMI is not known. The present study suggest that elevated levels of leptin might elicit the risk for CVD by signaling for the secretion of inflammatory cytokines especially, TNF-α. Methods: Blood samples were collected from 100 CVD subjects diagnosed for AMI immediately after their admission to the hospital and serum leptin, insulin, glucose, lipids and inflammatory marker such as TNF-α were measured. 5ml random (non-fasting) blood was collected from 100 non-CVD (control) subjects and the results obtained in case of AMI subjects were compared with that of the control subjects. The subjects under study included both men and women belonging to the age group of 35-75 and they were classified based on their BMI as normal weight, overweight and obese. Results: Circulating levels of leptin are found to be elevated in obese control subjects and in patients with AMI irrespective of their Body Mass Index (BMI). In addition, leptin is also found to be positively correlated to serum triglycerides, insulin and TNF-α in AMI subjects. MANOVA analysis suggests that leptin might influence the synthesis of insulin and TNF-α. This is the first report relating leptin to TNF-α in Chennai based population, India. Conclusions: Hyperleptinemia might act as a risk marker for AMI. The present study suggests that at elevated levels, leptin may favor atherosclerosis by promoting the synthesis of TNF-α and insulin. However, our report warrants further investigation both in vitro and in vivo to determine the exact mechanism behind the pro-atherogenic role of leptin. The observed positive correlation between leptin and BMI in both AMI and control subjects suggests that obese subjects manifest leptin resistance and hence, they possess a greater risk for the incidence of CVD. © Nalini et al. Source

Cherian J.V.,Stanley Medical College and Hospital
Tropical gastroenterology : official journal of the Digestive Diseases Foundation | Year: 2010

The incidence of peptic ulcer disease has steadily declined throughout the world. The influence of seasonal changes on the incidence of peptic ulcer disease is not well established. The aim of the study was to identify the changing trends in the occurrence of peptic ulcer disease from a tertiary referral center in south India and to study the seasonal Correspondence: variation in the occurrence of peptic ulcer. Retrospective analysis of the endoscopic records between the years 1989 to 2004. There was a significant decrease in the endoscopic diagnosis of duodenal and gastric ulcers (DU and GU) over the years. Both duodenal and gastric ulcers were more common in men than women. Over the years, there was a steady increase in the proportion of women affected with both DU and GU. A steady increase in the meanage of endoscopic diagnosis of GU and DU was seen over the years. The adjusted seasonal index revealed an increase in the endoscopic diagnosis of GU and DU in the months October-March. The endoscopic diagnosis of DU and GU has shown a decreasing trend over the past 16 years. The adjusted seasonal index has shown an increasing trend between the months of October-March. Source

Krishnan A.,Stanley Medical College and Hospital
Annals of Coloproctology | Year: 2013

Liposarcomas are common tumors arising in the retroperitoneum. However, a primary mesenteric liposarcoma is a rare entity and less than 50 cases have been reported so far. Further, a liposarcoma arising in the transverse mesocolon is very unusual, and cases of multiple primary tumors arising from the transverse mesocolon are extremely rare. We want to report a case of a multiple primary mesenteric liposarcoma arising from the transverse mesocolon in a 63-year-old female who was successfully treated by surgery. Because a primary mesenteric liposarcoma is a rare entity, it should be considered with the differential diagnosis of an abdominal mesenchymal tumor. It can be diagnosed preoperatively by using contrast enhanced computed tomography and magnetic resonance imaging. The treatment for such a liposarcoma is surgical resection with sufficient surgical margin; the role of adjuvant therapy has yet to be defined. © 2013 The Korean Society of Coloproctology. Source

Nattusamy L.,PSG Institute of Medical science and Research | Singh S.,Stanley Medical College and Hospital
Annals of Tropical Medicine and Public Health | Year: 2012

Quadriplegia may be of acute, subacute, or chronic onset and may have varied etiologies. Leptospirosis can produce quadriplegia, secondary to hypokalemia, which occurs due to kaliuresis. Leptospirosis is under diagnosed and under reported in India. The clinical features of leptospirosis are non-specific. Combining clinical expertise and awareness with rapid tests for diagnosis will increase the recognition of patients with leptospirosis and hypokalemia. Renal involvement is common in leptospirosis. In our country, hypokalemic manifestations of leptospirosis are under reported. We report a case of quadriplegia due to hypokalemia, secondary to leptospirosis. Source

Kalaivani J.,Dr. M.G.R. Educational and Research Institute | Selvi R.,Stanley Medical College and Hospital | Raj S.P.,Dr. M.G.R. Educational and Research Institute
International Journal of Pharma and Bio Sciences | Year: 2016

Bacterial infections are the most common pathogenic infections, during the first month of post kidney transplantation. In this study, about 164 kidney transplanted patients were assessed for the presence of the pathogenic bacteria such as Escherichia coli, Klebsiella spp. etc. Urine samples collected from the patients were cultured for the isolation of bacteria and were identified using regular biochemical tests and antibiotic resistances assays. The incidence of infection was positive for 96 (58.54%) out of 164 patients. E. coli was mostly isolated bacteria with a frequency rate of 32.5%, followed by Klebsiella spp. (20%), Pseudomonas spp. (11.3%), Proteus spp. (8.4%), Acinetobacter spp. (7.5%), Citrobacter spp. (4.3%) and Streptococcus aureus (12.8%). All the Gram-negative bacteria were found to be sensitive to amikacin (92.4-100%) and other isolates showed sensitive to Cefotaxime, Imepenem and Gentamicin. Thus, the present study aims to implement a new prophylaxis regimen for the treatment of post-operative infection. Source

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