Dhaka, Bangladesh

Stamford University Bangladesh

Dhaka, Bangladesh

Stamford University Bangladesh is a private university in Bangladesh. It was established in 2002 under the Private University Act. Before starting as a university, its predecessor institution was known as a Stamford college group established in 1994, later it was upgraded as private university of Bangladesh in 2002 and appeared as Stamford University Bangladesh. It is also having the highest number of students among the private universities in Bangladesh. Stamford University is the first ISO certified university in Bangladesh. Wikipedia.

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Ahmed A.,Stamford University Bangladesh
International Journal of Advanced Structural Engineering | Year: 2017

Finite element (FE) analyses were performed to explore the prying influence on moment–rotation behaviour and to locate yielding zones of top- and seat-angle connections in author’s past research studies. The results of those FE analyses with experimental failure strategies of the connections were used to develop failure mechanisms of top- and seat-angle connections in the present study. Then a formulation was developed based on three simple failure mechanisms considering bending and shear deformations, effects of prying action on the top angle and stiffness of the tension bolts to estimate rationally the ultimate moment Mu of the connection, which is a vital parameter of the proposed four-parameter power model. Applicability of the proposed formulation is assessed by comparing moment-rotation (M–θr) curves and ultimate moment capacities with those measured by experiments and estimated by FE analyses and three-parameter power model. This study shows that proposed formulation and Kishi–Chen’s method both achieved close approximation driving M–θr curves of all given connections except a few cases of Kishi–Chen model, and Mu estimated by the proposed formulation is more rational than that predicted by Kishi–Chen’s method. © 2017, The Author(s).

An array of stress signals triggering the bacterial cellular stress response is well known in Escherichia coli and other bacteria. Heat stress is usually sensed through the misfolded outer membrane porin (OMP) precursors in the periplasm, resulting in the activation of σE (encoded by rpoE), which binds to RNA polymerase to start the transcription of genes required for responding against the heat stress signal. At the elevated temperatures, σE also serves as the transcription factor for σH (the main heat shock sigma factor, encoded by rpoH), which is involved in the expression of several genes whose products deal with the cytoplasmic unfolded proteins. Besides, oxidative stress in form of the reactive oxygen species (ROS) that accumulate due to heat stress, has been found to give rise to viable but non-culturable (VBNC) cells at the early stationary phase, which is in turn lysed by the σE-dependent process. Such lysis of the defective cells may generate nutrients for the remaining population to survive with the capacity of formation of colony forming units (CFUs). σH is also known to regulate the transcription of the major heat shock proteins (HSPs) required for heat shock response (HSR) resulting in cellular survival. Present review concentrated on the cellular survival against heat stress employing the harmonized impact of σE and σH regulons and the HSPs as well as their inter connectivity towards the maintenance of cellular survival. © 2015, Noor.

Amin M.L.,Gachon University | Amin M.L.,Stamford University Bangladesh | Joo J.Y.,Gachon University | Yi D.K.,Myongji University | An S.S.A.,Gachon University
Journal of Controlled Release | Year: 2015

Nanotechnology has emerged as a powerful tool for various therapeutic applications, solving many difficulties in both diagnosis and treatment. However, many obstacles in complex biological systems have impeded the successful application of therapeutic nanoparticles, and fine-tuning nanoparticle properties have become extremely important in developing highly effective nanomedicines. To this end, particles have been engineered in various ways, with a special emphasis on surface modifications. The nanoparticle surface contacts the biological environment, and is a crucial determinant of the response. Thus, surface coating, surface charge, conjugated molecules, shape, and topography have enormous impacts on the total behavior of nanoparticles, including their biodistribution, stability, target localization, cellular interaction, uptake, drug release, and toxicity. Hence, engineering of the particle surface would provide wider dimensions of control for the specific and precise functions in the development of smart nanomedicines. Moreover, local orientation of nanoparticles in vivo and orientations of surface molecules are critical for their efficacy. Herein, we analyze surface functionalities, focusing on their mechanisms and respective advantages, and summarize results of surface engineering and renovating applications of nanoparticles. © 2015 Elsevier B.V. All rights reserved.

Sutradhar K.B.,Stamford University Bangladesh | Sumi C.D.,Chung - Ang University
Drug Delivery | Year: 2016

There is no doubt that controlled and pulsatile drug delivery system is an important challenge in medicine over the conventional drug delivery system in case of therapeutic efficacy. However, the conventional drug delivery systems often offer a limited by their inability to drug delivery which consists of systemic toxicity, narrow therapeutic window, complex dosing schedule for long term treatment etc. Therefore, there has been a search for the drug delivery system that exhibit broad enhancing activity for more drugs with less complication. More recently, some elegant study has noted that, a new type of micro-electrochemical system or MEMS-based drug delivery systems called microchip has been improved to overcome the problems related to conventional drug delivery. Moreover, micro-fabrication technology has enabled to develop the implantable controlled released microchip devices with improved drug administration and patient compliance. In this article, we have presented an overview of the investigations on the feasibility and application of microchip as an advanced drug delivery system. Commercial manufacturing materials and methods, related other research works and current advancement of the microchips for controlled drug delivery have also been summarized. © 2014 Informa Healthcare USA, Inc.

Roy N.,The University of Asia Pacific | Tasnim S.,Stamford University Bangladesh | Mamun A.A.,Jahangirnagar University
Physics of Plasmas | Year: 2012

A rigorous theoretical investigation has been made on the formation of the nonlinear structures (viz., solitary waves, double layers) in a dusty electron-positron-ion plasma (containing inertialess degenerate electrons and positrons, cold, mobile, inertial ions, and negatively charged stationary dust). The pseudo potential method has been employed in this theoretical investigation. The basic features of the solitary waves and double layers, which are associated with positive ion dynamics and pressures of degenerate electrons and positrons, are identified. The co-existence of positive and negative solitary waves, and existence of either positive or negative double layers have been theoretically observed for certain range of different plasma parameters. The implications of our results in astrophysical compact objects have been briefly discussed. © 2012 American Institute of Physics.

Imam M.Z.,Stamford University Bangladesh | Sumi C.D.,Stamford University Bangladesh
BMC Complementary and Alternative Medicine | Year: 2014

Background: Cyperus rotundus Linn. (Cyperaceae) is used to treat inflammation, pain, fever, wounds, boils and blisters in folk medicine. This study evaluated the antinociceptive effect of the hydromethanol extract of whole plant of C. rotundus (HMCR).Methods: The antinociceptive activity of HMCR was investigated in thermal-induced (hot plate and tail immersion) and chemical-induced (formalin) nociception models in mice at three different doses (50, 100 and 200 mg/kg; p.o.). Morphine sulphate (5 mg/kg, i.p.) and diclofenac sodium (10 mg/kg, i.p.) were used as reference analgesic agents.Results: In the hot-plate and tail-immersion tests HMCR significantly increased the latency period to the thermal stimuli at all the tested doses (50, 100 and 200 mg/kg) (p < 0.05). The significant increase in latency is clear from the observations at 60 and 90 min. In formalin-induced paw licking test oral administration of HMCR at 100 and 200 mg/kg doses decreased the licking of paw in early phase. All the tested doses (50, 100 and 200 mg/kg) significantly decreased the licking of paw in late phase of the test (p < 0.001). The dose 200 mg/kg was most effective showing maximum percentage of inhibition of licking in both early (61.60%) and late phase (87.41%).Conclusion: These results indicate the antinociceptive effect of C. rotundus and suggest that this effect is mediated by both peripheral and central mechanisms. These results support the traditional use of this plant in different painful conditions. © 2014 Imam and Sumi; licensee BioMed Central Ltd.

Built environment consumes the bulk of the UK's fossil fuel. Schools account for 15% of the public sector's carbon emissions. Energy efficient building design can play a vital role in achieving the national carbon emission reduction target of 80% by 2050. Natural and mixed mode ventilation is at the forefront of suggested energy efficient strategies for reducing carbon emissions from schools while maintaining good indoor air quality and thermal comfort. However, it is challenging to naturally ventilate many urban school buildings through side openings because of high noise and particulate air pollution. An alternative strategy, such as multi floor operation of windcatchers was assessed in this research as a sole source of fresh air in teaching spaces. Dynamic thermal simulation (DTS) and computational fluid dynamics (CFD) simulations assessed the performance of the adopted natural ventilation (NV) strategy in meeting the approved requirements for fresh air, indoor air quality (IAQ) and summertime overheating. Simulation results show that it is challenging to meet approved guidelines on air quality and thermal comfort, only when windcatchers are employed for ventilation purpose. However, fan assisted ventilation in conjunction with windcatchers provided satisfactory results. Detailed performance assessments using CFD seem desirable to validate DTS based findings. © 2014 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

Amin M.L.,Stamford University Bangladesh
Drug Target Insights | Year: 2013

P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents are substrates to it and it impedes the absorption, permeability, and retention of the drugs, extruding them out of the cells. It is overexpressed in cancer cells and accountable for obstructing cell internalization of chemotherapeutic agents and for developing transporter mediated resistance by cancer cells during anti-tumor treatments. As it jeopardizes the success of drug delivery and cancer targeting, strategies are being developed to overcome P-gp mediated drug transport. This concise review represents a brief discussion on P-gp mediated drug transport and how it hinders the success of various therapies. Its main focus is on various strategies used to tackle this curb in the field of drug delivery and targeting. © the author(s). publisher and licensee Libertas Academica Ltd.

Imam M.Z.,Stamford University Bangladesh | Moniruzzaman M.,Stamford University Bangladesh
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance Lannea coromandelica (Houtt.) Merr. is a plant locally called "Jiga", found all over Bangladesh. Leaf of the plant is traditionally used in the treatment of local swellings, pains of body, toothache etc. This study evaluated the antinociceptive effect of the ethanol extract of L. coromandelica leaves (EELC). Materials and methods The antinociceptive activity of the extract (at the doses of 50, 100, and 200 mg/kg) was evaluated by using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion, formalin, and glutamate test. To verify the possible involvement of opioid receptor in the central antinociceptive effect of EELC, naloxone was used to antagonize the effect. Besides, the involvements of ATP-sensitive K+ channel and cGMP pathway were also justified by using glibenclemide and methylene blue. Results EELC demonstrated significant dose-dependent antinociceptive activity in the chemical- and heat-induced nociception in mice models (p<0.05). These findings imply the involvement of both peripheral and central antinociceptive mechanisms. The use of naloxone confirmed the association of opioid receptors in the central antinociceptive effect. EELC also showed the involvements of ATP-sensitive K+ channel and cGMP pathway for antinociceptive activity. Conclusions This study reported the antinociceptive activity of the leaf of L. coromandelica and rationalized the traditional use of the leaf in the treatment of different painful conditions. © 2014 Elsevier Ireland Ltd.

OBJECTIVE: The main objectives of this study were to qualitatively evaluate the profile of phytochemical constituents present in methanolic extract of Microcos paniculata bark (BME) and fruit (FME), as well as to evaluate their anti-inflammatory, analgesic and antipyretic activities.METHODS: Phytochemical constituents of BME and FME were determined by different qualitative tests such as Molisch's test, Fehling's test, alkaloid test, frothing test, FeCl3 test, alkali test, Salkowski's test and Baljet test. The anti-inflammatory, analgesic and antipyretic activities of the extracts were evaluated through proteinase-inhibitory assay, xylene-induced ear edema test, cotton pellet-induced granuloma formation in mice, formalin test, acetic acid-induced writhing test, tail immersion test and Brewer's yeast-induced pyrexia in mice.RESULTS: M. paniculata extracts revealed the presence of carbohydrates, alkaloids, saponins, tannins, flavonoids and triterpenoids. All of the extracts showed significant (P<0.05, vs aspirin group) proteinase-inhibitory activity, whereas the highest effect elicited by plant extracts was exhibited by the BME (75.94% proteinase inhibition activity) with a half-maximal inhibitory concentration (IC50) of 61.31 μg/mL. Each extract at the doses of 200 and 400 mg/kg body weight showed significant (P<0.05, vs control) percentage inhibition of ear edema and granuloma formation. These extracts significantly (P<0.05, vs control) reduced the paw licking and abdominal writhing of mice. In addition, BME 400 mg/kg, and FME at 200 and 400 mg/kg showed significant (P<0.05, vs control) analgesic activities at 60 min in the tail immersion test. Again, the significant (P<0.05, vs control) post-treatment antipyretic activities were found by BME 200 and 400 mg/kg and FME 400 mg/kg respectively.CONCLUSION: Study results indicate that M. paniculata may provide a source of plant compounds with anti-inflammatory, analgesic and antipyretic activities.

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